Abstract: The invention provides a p38 MAPK inhibitor of Formula I, or a pharmaceutically acceptable salt or solvate thereof: for use in the treatment or prevention of hypercytokinemia in a human patient; wherein R is C1-3alkyl, optionally substituted by one or more halo, NR1R2 or hydroxy, and R1and R2 are independently H, halo or C1-3alkyl, optionally substituted by one or more F. Also provided are compositions for use in the treatment or prevention of hypercytokinemia comprising the p38 MAPK inhibitor of Formula I; and methods for treating or preventing hypercytokinemia in a human patient in need thereof comprising administering to the patient a therapeutically or prophylactically effective amount of a p38 MAPK inhibitor of Formula I. The invention also provides a p38 MAPK inhibitor and an antimicrobial agent, such as an antiviral agent, for use in the treatment or prevention of hypercytokinemia.

Abstract: An internal combustion engine is provided with oil intake pipes defining oil inlets on both sides of a tunnel type sump. Each oil intake pipe includes a valve which is operable to close the respective flowpath when the respective sump portion is tilted upwardly about the length axis of the engine. The inlets may be arranged to remain submerged in a minimum quantity of oil which is retained in each sump portion while the engine is tilted through its maximum angular range about both length and width axes.