Patents by Inventor Paul Andrew Oeth

Paul Andrew Oeth has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Detection and quantification of biomolecules using mass spectrometry
    Patent number: 9051608
    Abstract: The present invention is directed in part to a method for detecting a target nucleic acid using detector oligonucleotides detectable by mass spectrometry. This method takes advantage of the 5? to 3? nuclease activity of a nucleic acid polymerase to cleave annealed oligonucleotide probes from hybridized duplexes and releases labels for detection by mass spectrometry. This process is easily incorporated into a polymerase chain reaction (PCR) amplification assay. The method also includes embodiments directed to quantitative analysis of target nucleic acids.
    Type: Grant
    Filed: February 13, 2013
    Date of Patent: June 9, 2015
    Assignee: AGENA BIOSCIENCE, INC.
    Inventors: Dirk Johannes Van Den Boom, Paul Andrew Oeth, Payam Mahboubi
  • DETECTION AND QUANTIFICATION OF BIOMOLECULES USING MASS SPECTROMETRY
    Publication number: 20140235464
    Abstract: The present invention is directed in part to a method for detecting a target nucleic acid using detector oligonucleotides detectable by mass spectrometry. This method takes advantage of the 5? to 3? nuclease activity of a nucleic acid polymerase to cleave annealed oligonucleotide probes from hybridized duplexes and releases labels for detection by mass spectrometry. This process is easily incorporated into a polymerase chain reaction (PCR) amplification assay. The method also includes embodiments directed to quantitative analysis of target nucleic acids.
    Type: Application
    Filed: February 13, 2013
    Publication date: August 21, 2014
    Applicant: SEQUENOM, INC.
    Inventors: Dirk Johannes VAN DEN BOOM, Paul Andrew Oeth, Payam Mahboubi
  • Nucleic acid-based tests for prenatal gender determination
    Patent number: 8709726
    Abstract: Provided herein are compositions, processes and kits for noninvasive, early determination of fetal sex from, and/or amount of fetal nucleic acid in, an extracellular nucleic acid sample from a pregnant female. Such compositions, processes and kits are useful for detection of low genomic copy numbers of male fetal nucleic acid in a high copy number background of female nucleic acid, thereby determining the sex of a fetus and/or amount of fetal nucleic acid in a sample.
    Type: Grant
    Filed: March 10, 2009
    Date of Patent: April 29, 2014
    Assignee: Sequenom, Inc.
    Inventors: Paul Andrew Oeth, Payam Mahboubi, Min Seob Lee
  • Nucleic acid-based tests for RhD typing, gender determination and nucleic acid quantification
    Patent number: 8551707
    Abstract: The invention in part provides nucleic acid-based assays, which are particularly useful for non-invasive prenatal testing. The invention in part provides compositions and methods for RhD typing, detecting the presence of fetal nucleic in a sample, determining the relative amount of fetal nucleic acid in a sample and determining the sex of a fetus, wherein each of the assays may be performed alone or in combination.
    Type: Grant
    Filed: December 12, 2011
    Date of Patent: October 8, 2013
    Assignee: Sequenom, Inc.
    Inventors: Paul Andrew Oeth, Mathias Ehrich
  • Detection and quantification of biomolecules using mass spectrometry
    Patent number: 8383795
    Abstract: The present invention is directed in part to a method for detecting a target nucleic acid using detector oligonucleotides detectable by mass spectrometry. This method takes advantage of the 5? to 3? nuclease activity of a nucleic acid polymerase to cleave annealed oligonucleotide probes from hybridized duplexes and releases labels for detection by mass spectrometry. This process is easily incorporated into a polymerase chain reaction (PCR) amplification assay. The method also includes embodiments directed to quantitative analysis of target nucleic acids.
    Type: Grant
    Filed: March 3, 2011
    Date of Patent: February 26, 2013
    Assignee: Sequenom, Inc.
    Inventors: Dirk Johannes Van Den Boom, Paul Andrew Oeth, Payam Mahboubi
  • NUCLEIC ACID-BASED TESTS FOR RHD TYPING, GENDER DETERMINATION AND NUCLEIC ACID QUANTIFICATION
    Publication number: 20120214680
    Abstract: The invention in part provides nucleic acid-based assays, which are particularly useful for non-invasive prenatal testing. The invention in part provides compositions and methods for RhD typing, detecting the presence of fetal nucleic in a sample, determining the relative amount of fetal nucleic acid in a sample and determining the sex of a fetus, wherein each of the assays may be performed alone or in combination.
    Type: Application
    Filed: December 12, 2011
    Publication date: August 23, 2012
    Applicant: SEQUENOM, INC.
    Inventors: Paul Andrew OETH, Mathias Ehrich
  • DETECTION AND QUANTIFICATION OF BIOMOLECULES USING MASS SPECTROMETRY
    Publication number: 20110160093
    Abstract: The present invention is directed in part to a method for detecting a target nucleic acid using detector oligonucleotides detectable by mass spectrometry. This method takes advantage of the 5? to 3? nuclease activity of a nucleic acid polymerase to cleave annealed oligonucleotide probes from hybridized duplexes and releases labels for detection by mass spectrometry. This process is easily incorporated into a polymerase chain reaction (PCR) amplification assay. The method also includes embodiments directed to quantitative analysis of target nucleic acids.
    Type: Application
    Filed: March 3, 2011
    Publication date: June 30, 2011
    Applicant: SEQUENOM, INC.
    Inventors: Dirk Johannes Van Den Boom, Paul Andrew Oeth, Payam Mahboubi
  • Detection and quantification of biomolecules using mass spectrometry
    Patent number: 7902345
    Abstract: The present invention is directed in part to a method for detecting a target nucleic acid using detector oligonucleotides detectable by mass spectrometry. This method takes advantage of the 5? to 3? nuclease activity of a nucleic acid polymerase to cleave annealed oligonucleotide probes from hybridized duplexes and releases labels for detection by mass spectrometry. This process is easily incorporated into a polymerase chain reaction (PCR) amplification assay. The method also includes embodiments directed to quantitative analysis of target nucleic acids.
    Type: Grant
    Filed: June 4, 2008
    Date of Patent: March 8, 2011
    Assignee: Sequenom, Inc.
    Inventors: Dirk Johannes Van Den Boom, Paul Andrew Oeth, Payam Mahboubi
  • USE OF THERMOSTABLE ENDONUCLEASES FOR GENERATING REPORTER MOLECULES
    Publication number: 20100279295
    Abstract: Provided are compositions and methods for amplifying, capturing and/or detecting target nucleic acids using cleavable oligonucleotides.
    Type: Application
    Filed: March 17, 2010
    Publication date: November 4, 2010
    Applicant: SEQUENOM, INC.
    Inventors: Margaret Ann Roy, Paul Andrew Oeth
  • NUCLEIC ACID-BASED TESTS FOR PRENATAL GENDER DETERMINATION
    Publication number: 20090317817
    Abstract: Provided herein are compositions, processes and kits for noninvasive, early determination of fetal sex from, and/or amount of fetal nucleic acid in, an extracellular nucleic acid sample from a pregnant female. Such compositions, processes and kits are useful for detection of low genomic copy numbers of male fetal nucleic acid in a high copy number background of female nucleic acid, thereby determining the sex of a fetus and/or amount of fetal nucleic acid in a sample.
    Type: Application
    Filed: March 10, 2009
    Publication date: December 24, 2009
    Applicant: Sequenom, Inc.
    Inventors: Paul Andrew Oeth, Payam Mahboubi, Min Seob Lee
  • DETECTION AND QUANTIFICATION OF BIOMOLECULES USING MASS SPECTROMETRY
    Publication number: 20090111712
    Abstract: The present invention is directed in part to a method for detecting a target nucleic acid using detector oligonucleotides detectable by mass spectrometry. This method takes advantage of the 5? to 3? nuclease activity of a nucleic acid polymerase to cleave annealed oligonucleotide probes from hybridized duplexes and releases labels for detection by mass spectrometry. This process is easily incorporated into a polymerase chain reaction (PCR) amplification assay. The method also includes embodiments directed to quantitative analysis of target nucleic acids.
    Type: Application
    Filed: June 4, 2008
    Publication date: April 30, 2009
    Applicant: SEQUENOM, INC.
    Inventors: Dirk Johannes Van Den Boom, Paul Andrew Oeth, Payam Mahboubi