Patents by Inventor Paul Arnold Van De Wiel

Paul Arnold Van De Wiel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ASSESSMENT OF CELLULAR SIGNALING PATHWAY ACTIVITY USING LINEAR COMBINATION(S) OF TARGET GENE EXPRESSIONS
    Publication number: 20230030858
    Abstract: The present application mainly relates to specific methods for inferring activity of a cellular signaling pathway in tissue and/or cells of a medical subject based at least on expression levels of one or more target gene(s) of the cellular signaling pathway measured in an extracted sample of the tissue and/or cells of the medical subject, an apparatus comprising a digital compressor configured to perform such methods and a non-transitory storage medium storing instructions that are executable by a digital processing device to perform such methods.
    Type: Application
    Filed: April 6, 2022
    Publication date: February 2, 2023
    Applicant: InnoSIGN B.V.
    Inventors: Hendrik Jan VAN OOIJEN, Wilhelmus Franciscus Johannes VERHAEGH, Paul Arnold VAN DE WIEL
  • Assessment of cellular signaling pathway activity using linear combination(s) of target gene expressions
    Patent number: 11306360
    Abstract: The present application mainly relates to specific methods for inferring activity of a cellular signaling pathway in tissue and/or cells of a medical subject based at least on expression levels of one or more target gene(s) of the cellular signaling pathway measured in an extracted sample of the tissue and/or cells of the medical subject, an apparatus comprising a digital compressor configured to perform such methods and a non-transitory storage medium storing instructions that are executable by a digital processing device to perform such methods.
    Type: Grant
    Filed: December 18, 2013
    Date of Patent: April 19, 2022
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Hendrik Jan Van Ooijen, Wilhelmus Franciscus Johannes Verhaegh, Paul Arnold Van De Wiel
  • Selective lysis of cells
    Patent number: 11072813
    Abstract: Methods and devices for detection of micro-organisms present or suspected to be present within a mammalian blood sample are provided. A selective lysis is obtained by incubating the sample in a non-ionic detergent under alkaline conditions.
    Type: Grant
    Filed: March 26, 2019
    Date of Patent: July 27, 2021
    Assignee: Koninklijke Philips N.V.
    Inventors: Bart Edward Gusta Jozef Van Meerbergen, Oana Mihaela Piciu, Ron Gill, Kristiane Anne Schmidt, Sieglinde Neerken, Marc Wilhelmus Gijsbert Ponjee, Zeynep Seflek Unay, Roel Penterman, Paul Arnold Van De Wiel
  • SELECTIVE LYSIS OF CELLS
    Publication number: 20190218595
    Abstract: Methods and devices for detection of micro-organisms present or suspected to be present within a mammalian blood sample are provided. A selective lysis is obtained by incubating the sample in a non-ionic detergent under alkaline conditions.
    Type: Application
    Filed: March 26, 2019
    Publication date: July 18, 2019
    Inventors: Bart Edward Gusta Jozef Van MEERBERGEN, Oana Mihaela PICIU, Ron GILL, Kristiane Anne SCHMIDT, Sieglinde NEERKEN, Marc Wilhelmus Gijsbert PONJEE, Zeynep Seflek Unay, Roel PENTERMAN, Paul Arnold VAN DE WIEL
  • Selective lysis of cells
    Patent number: 10308976
    Abstract: Methods and devices for the selective lysis of cells in a sample comprising micro-organisms such as bacteria are provided. The selective lysis is obtained by incubating the sample in a non-ionic detergent under alkaline conditions.
    Type: Grant
    Filed: December 7, 2010
    Date of Patent: June 4, 2019
    Assignee: Koninklijke Philips N.V.
    Inventors: Bart Edward Jozef Gusta Van Meerbergen, Oana Mihaela Piciu, Ron Gill, Kristiane Anne Schmidt, Sieglinde Neerken, Marc Wilhelmus Gijsbert Ponjee, Zeynep Seflek, Roel Penterman, Paul Arnold Van De Wiel
  • ASSESSMENT OF CELLULAR SIGNALING PATHWAY ACTIVITY USING LINEAR COMBINATION(S) OF TARGET GENE EXPRESSIONS
    Publication number: 20150347672
    Abstract: The present application mainly relates to specific methods for inferring activity of a cellular signaling pathway in tissue and/or cells of a medical subject based at least on expression levels of one or more target gene(s) of the cellular signaling pathway measured in an extracted sample of the tissue and/or cells of the medical subject, an apparatus comprising a digital compressor configured to perform such methods and a non-transitory storage medium storing instructions that are executable by a digital processing device to perform such methods.
    Type: Application
    Filed: December 18, 2013
    Publication date: December 3, 2015
    Inventors: Hendrik Jan VAN OOIJEN, Wilhelmus Franciscus Johannes VERHAEGH, Paul Arnold VAN DE WIEL
  • SELECTIVE LYSIS OF CELLS
    Publication number: 20130171615
    Abstract: Methods and devices for the selective lysis of cells in a sample comprising micro-organisms such as bacteria are provided. The selective lysis is obtained by incubating the sample in a non-ionic detergent under alkaline conditions.
    Type: Application
    Filed: December 7, 2010
    Publication date: July 4, 2013
    Applicant: BIOCARTIS SA
    Inventors: Bart Edward Jozef Gusta Van Meerbergen, Oana Mihaela Piciu, Ron Gill, Kristiane Anne Schmidt, Sieglinde Neerken, Marc Wilhelmus Gijsbert Ponjee, Zeynep Seflek, Roel Penterman, Paul Arnold Van De Wiel