Patents by Inventor Paul B. Card

Paul B. Card has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NMR detection of foreign PAS domain ligands
    Patent number: 7645569
    Abstract: Specific binding of a foreign core ligand to a PAS domain, wherein the PAS domain is predetermined, prefolded in its native state, and comprises a hydrophobic core that has no NMR-apparent a priori formed ligand cavity, is determined using NMR spectra of the PAS domain in the presence and absence of a foreign ligand bound within the hydrophobic core. A functional surface binding specificity of a PAS domain is changed by (a) introducing into the hydrophobic core of the PAS domain a foreign ligand of the PAS domain; and (b) detecting a change in the functional surface binding specificity of the PAS domain.
    Type: Grant
    Filed: October 1, 2003
    Date of Patent: January 12, 2010
    Assignee: Board of Regents, The University of Texas System
    Inventors: Kevin H. Gardner, Carlos A. Amezcua, Paulus J. A. Erbel, Paul B. Card
  • NMR detection of foreign PAS domain ligands
    Publication number: 20040121409
    Abstract: Specific binding of a foreign core ligand to a PAS domain, wherein the PAS domain is predetermined, prefolded in its native state, and comprises a hydrophobic core that has no NMR-apparent a priori formed ligand cavity, is determined by (a) detecting a first NMR spectrum of the PAS domain in the presence of a foreign ligand; and (b) comparing the first NMR spectrum with a second NMR spectrum of the PAS domain in the absence of the ligand to infer the presence the ligand specifically bound within the hydrophobic core of the PAS domain.
    Type: Application
    Filed: October 1, 2003
    Publication date: June 24, 2004
    Applicant: Board of Regents, The University of Texas System
    Inventors: Kevin H. Gardner, Carlos A. Amezcua, Paulus J.A. Erbel, Paul B. Card