Patents by Inventor Paul B. McCray

Paul B. McCray has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • FORMULATIONS TO ENHANCE THE DELIVERY OF GENE THERAPY VECTORS
    Publication number: 20250144247
    Abstract: Method to enhance the delivery of one or more gene therapy vectors to cells comprising contacting said cells with a hypertonic solution before. after or simultaneously with said one or more gene therapy vectors.
    Type: Application
    Filed: November 4, 2024
    Publication date: May 8, 2025
    Inventors: Ashley Cooney, Patrick Sinn, Paul B. McCray, JR.
  • COMPOSITIONS AND METHODS FOR THE TREATMENT OF CYSTIC FIBROSIS
    Publication number: 20230174600
    Abstract: Provided herein are polynucleotides, lentiviral vectors, pharmaceutical compositions, and methods of making and using the same, e.g., for treatment of cystic fibrosis (CF).
    Type: Application
    Filed: April 27, 2021
    Publication date: June 8, 2023
    Inventors: Paul B. McCray, JR., Patrick Sinn, Laura Marquez Lora
  • REPEATED ADMINISTRATION OF LENTIVIRAL VECTORS TO RESPIRATORY CELLS
    Publication number: 20180271783
    Abstract: The invention provides methods for administering lentiviral vectors to the respiratory system of a patient to treat a disease.
    Type: Application
    Filed: May 11, 2018
    Publication date: September 27, 2018
    Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Paul B. McCray, Patrick L. Sinn
  • Methods of improving RNAi in well-differentiated airway epithelia
    Patent number: 9987299
    Abstract: The present invention relates to methods of reducing a level of a target mRNA in a well-differentiated airway epithelial cell by contacting the cell with a facilitating agent followed by contacting the cell with a therapeutic RNAi agent, wherein the facilitating agent comprises a Platelet-activating factor receptor (PAFR) ligand.
    Type: Grant
    Filed: May 4, 2015
    Date of Patent: June 5, 2018
    Assignee: University of Iowa Research Foundation
    Inventors: Paul B. McCray, Jr., Beverly L. Davidson, Michael A. Apicella, Sateesh Krishnamurthy
  • METHODS FOR PRODUCING AND USING IN VIVO PSEUDOTYPED RETROVIRUSES
    Publication number: 20170166924
    Abstract: The present invention provides novel pseudotyped retroviral vectors that can transduce human and other cells. Vectors are provided that are packaged efficiently in packaging cells and cell lines to generate high titer recombinant virus stocks expressing novel envelope glycoproteins. The present invention further relates to compositions for gene therapy.
    Type: Application
    Filed: October 26, 2016
    Publication date: June 15, 2017
    Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Beverly L. Davidson, Paul B. McCray, JR.
  • METHOD OF REGULATING CFTR EXPRESSION AND PROCESSING
    Publication number: 20160108406
    Abstract: The present invention relates to methods of reducing ?F508-CFTR ubiquitination or degradation, or increasing ?F508-CFTR processing or function in a CF cell comprising contacting the cell with a therapeutic agent that inhibits NEDD8, FBXO2, and/or SYVN1 expression in the cell.
    Type: Application
    Filed: October 8, 2015
    Publication date: April 21, 2016
    Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Paul B. McCray, Shyam Ramachandran
  • Methods to enhance RNAi oligonucleotide delivery to respiratory epithelial cells
    Patent number: 9272016
    Abstract: The present invention relates to methods of reducing a level of a target mRNA in a well-differentiated airway epithelial cell by contacting the cell with a sensitizing agent followed by contacting the cell with a therapeutic RNAi agent.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: March 1, 2016
    Assignee: University of Iowa Research Foundation
    Inventors: Paul B. McCray, Jr., Beverly L. Davidson, Sateesh Krishnamurthy
  • Method of delivering vectors to pancreas and lungs by cannulating the aorta
    Patent number: 9211347
    Abstract: The present invention relates to a safe and effective way to deliver and express therapeutic compositions (e.g., transgenes) to the pancreas and lungs of a mammal.
    Type: Grant
    Filed: September 18, 2013
    Date of Patent: December 15, 2015
    Assignee: University of Iowa Research Foundation
    Inventors: Aliye Uc, Paul B. McCray, Beverly L. Davidson, Abhay Divekar
  • METHODS OF IMPROVING RNAI IN WELL-DIFFERENTIATED AIRWAY EPITHELIA
    Publication number: 20150313924
    Abstract: The present invention relates to methods of reducing a level of a target mRNA in a well-differentiated airway epithelial cell by contacting the cell with a facilitating agent followed by contacting the cell with a therapeutic RNAi agent, wherein the facilitating agent comprises a Platelet-activating factor receptor (PAFR) ligand.
    Type: Application
    Filed: May 4, 2015
    Publication date: November 5, 2015
    Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Paul B. McCray, JR., Beverly L. Davidson, Michael A. Apicella, Sateesh Krishnamurthy
  • METHOD OF DELIVERING VECTORS TO PANCREAS AND LUNGS BY CANNULATING THE AORTA
    Publication number: 20140081240
    Abstract: The present invention relates to a safe and effective way to deliver and express therapeutic compositions (e.g., transgenes) to the pancreas and lungs of a mammal.
    Type: Application
    Filed: September 18, 2013
    Publication date: March 20, 2014
    Applicant: University of Iowa Research Foundation
    Inventors: Aliye Uc, Paul B. McCray, Beverly L. Davidson, Abhay Divekar
  • METHODS TO ENHANCE RNAI OLIGONUCLEOTIDE DELIVERY TO RESPIRATORY EPITHELIAL CELLS
    Publication number: 20130281372
    Abstract: The present invention relates to methods of reducing a level of a target mRNA in a well-differentiated airway epithelial cell by contacting the cell with a sensitizing agent followed by contacting the cell with a therapeutic RNAi agent.
    Type: Application
    Filed: March 14, 2013
    Publication date: October 24, 2013
    Applicant: University of Iowa Research Foundation
    Inventors: Paul B. McCray, JR., Beverly L. Davidson, Sateesh Krishnamurthy
  • Methods and compositions related to PLUNC surfactant polypeptides
    Patent number: 7951781
    Abstract: Embodiments include compositions and methods for lower the surface tension of a liquid-air interface by contacting such interface with all or part of a PLUNC polypeptide.
    Type: Grant
    Filed: November 2, 2007
    Date of Patent: May 31, 2011
    Assignee: University of Iowa Research Foundation
    Inventors: Paul B. McCray, Jr., Lokesh Gakhar, Rama K. Mallampalli, Subramanian Ramaswamy, Jennifer Bartlett
  • Methods for producing and using in vivo pseudotyped retroviruses using envelope glycoproteins from lymphocytic choriomeningitis virus (LCMV)
    Patent number: 7931893
    Abstract: The present invention provides novel pseudotyped retroviral vectors that can transduce human and other cells. Vectors are provided that are packaged efficiently in packaging cells and cell lines to generate high titer recombinant virus stocks expressing novel envelope glycoproteins. The present invention further relates to compositions for gene therapy.
    Type: Grant
    Filed: June 11, 2008
    Date of Patent: April 26, 2011
    Assignee: University of Iowa Research Foundation
    Inventors: Paul B. McCray, Jr., Beverly L. Davidson, Colleen Stein
  • RNA interference in respiratory epithelial cells
    Patent number: 7687475
    Abstract: The present invention is directed to small interfering RNA molecules targeted against a gene of interest in respiratory epithelial cells, and methods of using these RNA molecules.
    Type: Grant
    Filed: October 16, 2007
    Date of Patent: March 30, 2010
    Assignee: University of Iowa Research Foundation
    Inventors: Paul B. McCray, Beverly L. Davidson, Anthony J. Fischer, Hong P. Jia, Maureen D. Donovan, Patrick L. Sinn, Mark Aaron Behlke
  • REPEATED ADMINISTRATION OF LENTIVIRAL VECTORS TO RESPIRATORY CELLS
    Publication number: 20100076061
    Abstract: The invention provides methods for administering lentiviral vectors to the respiratory system of a patient to treat a disease.
    Type: Application
    Filed: April 30, 2009
    Publication date: March 25, 2010
    Applicant: University of Iowa Research Foundation
    Inventors: Paul B. McCray, Patrick L. Sinn
  • HALIDES IN THE TREATMENT OF PATHOGENIC INFECTION
    Publication number: 20090246146
    Abstract: The present invention relates to the use of halides and halide salts for the treatment of microbial infections, including those caused by bacteria, fungi and viruses. The present invention takes advantage of endogenous immune function and augments this system using a non-toxic and inexpensive reagent that can be delivered to mucosal surfaces, for example, orally, topically, opthalmically and via inhalation.
    Type: Application
    Filed: January 9, 2009
    Publication date: October 1, 2009
    Inventors: BOTOND BANFI, Anthony Fischer, Joseph Zabner, Lakshmi Durairaj, Daniel Lorentzen, Paul B. McCray, JR.
  • METHODS FOR PRODUCING AND USING IN VIVO PSEUDOTYPED RETROVIRUSES
    Publication number: 20090118212
    Abstract: The present invention provides novel pseudotyped retroviral vectors that can transduce human and other cells. Vectors are provided that are packaged efficiently in packaging cells and cell lines to generate high titer recombinant virus stocks expressing novel envelope glycoproteins. The present invention further relates to compositions for gene therapy.
    Type: Application
    Filed: November 21, 2007
    Publication date: May 7, 2009
    Inventors: Beverly L. Davidson, Paul B. McCray, JR.
  • Methods and Compositions Related to PLUNC Surfactant Polypeptides
    Publication number: 20090110756
    Abstract: Embodiments include compositions and methods for lower the surface tension of a liquid-air interface by contacting such interface with all or part of a PLUNC polypeptide.
    Type: Application
    Filed: November 2, 2007
    Publication date: April 30, 2009
    Inventors: Paul B. McCray, JR., Lokesh Gakhar, Rama K. Mallampalli, Subramanian Ramaswamy, Jennifer Bartlett
  • RNA interference in respiratory epithelial cells
    Publication number: 20090029934
    Abstract: The present invention is directed to small interfering RNA molecules targeted against a gene of interest in respiratory epithelial cells, and methods of using these RNA molecules.
    Type: Application
    Filed: October 16, 2007
    Publication date: January 29, 2009
    Inventors: Paul B. McCray, Beverly L. Davidson, Anthony J. Fischer, Hong P. Jia, Maureen D. Donovan, Patrick L. Sinn, Mark Aaron Behlke
  • Compositions and methods related to modified retroviral vectors for restricted, site specific integration
    Patent number: 7470777
    Abstract: Embodiments of the invention include compositions comprising and methods utilizing a retroviral integrase complex comprising a recombinant integrase having a domain comprising a non-native protein binding site, and a DNA binding protein comprising a DNA binding domain and a peptide binding domain that binds the non-native protein binding site of the recombinant integrase.
    Type: Grant
    Filed: December 22, 2005
    Date of Patent: December 30, 2008
    Assignees: Iowa State University Research Foundation, Inc., University of Iowa Research Foundation
    Inventors: Paul B. McCray, Jr., Patrick L. Sinn, Daniel F. Voytas, Junbiao Dai