Patents by Inventor Paul Bamborough

Paul Bamborough has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Fused heteroaryl derivatives for use as P38 kinase inhibitors
    Patent number: 7642276
    Abstract: Compounds of formula (I): wherein A is a 5-membered heteroaryl ring are inhibitors of p38 kinase and are useful in the treatment of conditions or disease states mediated by p38 kinase activity or mediated by cytokines produced by the activity of p38, such as rheumatoid arthritis.
    Type: Grant
    Filed: July 30, 2003
    Date of Patent: January 5, 2010
    Assignee: SmithKline Beecham Corporation
    Inventors: Richard Martyn Angell, Ian Robert Baldwin, Paul Bamborough, Nigel Marc Deboeck, Timothy Longstaff, Stephen Swanson
  • AMINOPYRAZINE DERIVATIVES AND COMPOSITIONS
    Publication number: 20090318472
    Abstract: The present invention relates to aminopyrazine derivatives, compositions and medicaments containing the same, as well as processes for the preparation and use of such compounds, compositions and medicaments. Such aminopyrazine derivatives are useful in the treatment of diseases associated with inappropriate tyrosine and/or serine/threonine kinase activity.
    Type: Application
    Filed: August 24, 2009
    Publication date: December 24, 2009
    Applicant: SmithKline Beecham Corporation
    Inventors: John Michael ALBERTI, Harold David DREWRY, Drysdale David MILLER, Paul BAMBOROUGH
  • Aminopyrazine derivatives and compositions
    Patent number: 7598251
    Abstract: The present invention relates to aminopyrazine derivatives, compositions and medicaments containing the same, as well as processes for the preparation and use of such compounds, compositions and medicaments. Such aminopyrazine derivatives are useful in the treatment of diseases associated with inappropriate tyrosine and/or serine/threonine kinase activity.
    Type: Grant
    Filed: October 31, 2008
    Date of Patent: October 6, 2009
    Assignee: SmithKline Beecham Corporation
    Inventors: Michael John Alberti, David Harold Drewry, David Drysdale Miller, Paul Bamborough
  • Biphenyl carboxylic amide p38 kinase inhibitors
    Patent number: 7572790
    Abstract: Compound of formula (I): or pharmaceutically acceptable derivatives thereof, and their use as pharmaceuticals, particularly as p38 kinase inhibitors.
    Type: Grant
    Filed: April 7, 2004
    Date of Patent: August 11, 2009
    Assignee: SmithKline Beecham Corporation
    Inventors: Nicola Mary Aston, Paul Bamborough, Katherine Louise Jones, Vipulkumar Kantibhai Patel, Stephen Swanson, Ann Louise Walker
  • Novel Compounds
    Publication number: 20090156597
    Abstract: Novel substituted 2,4,8-trisubstituted 8H-pyrido[2,3-d]pyrimidin-7-one containing compounds and compositions, and their use in therapy as CSBP/RK/p38 kinase inhibitors.
    Type: Application
    Filed: June 4, 2008
    Publication date: June 18, 2009
    Inventors: James F. Callahan, Jeffrey C. Boehm, Anthony William James Cooper, Stefano Livia, Paul Bamborough, Neysa Nevins, Zehong Wan, Beth A. Norton, Xichen Lin
  • Nicotinamide derivatives useful as p38 inhibitors
    Patent number: 7514456
    Abstract: Compounds of formula (I): are inhibitors of p38 kinase and are useful in the treatment of conditions or disease states mediated by p38 kinase activity or mediated by cytokines produced by the activity of p38.
    Type: Grant
    Filed: August 7, 2006
    Date of Patent: April 7, 2009
    Assignee: SmithKline Beecham Corporation
    Inventors: Nicola Mary Aston, Paul Bamborough, Ann Louise Walker
  • AMINOPYRAZINE DERIVATIVES AND COMPOSITIONS
    Publication number: 20090062307
    Abstract: The present invention relates to aminopyrazine derivatives, compositions and medicaments containing the same, as well as processes for the preparation and use of such compounds, compositions and medicaments. Such aminopyrazine derivatives are useful in the treatment of diseases associated with inappropriate tyrosine and/or serine/threonine kinase activity.
    Type: Application
    Filed: October 31, 2008
    Publication date: March 5, 2009
    Applicant: SMITHKLINE BEECHAM CORPORATION
    Inventors: Michael John Alberti, David Harold Drewry, David Drysdale Miller, Paul Bamborough
  • Fused Heteroaryl Derivatives for Use as P38 Kinase Inhibitors
    Publication number: 20090023725
    Abstract: Compounds of formula (I): are inhibitors of p38 kinase and are useful in the treatment of conditions or disease states mediated by p38 kinase activity or mediated by cytokines produced by the activity of p38.
    Type: Application
    Filed: January 27, 2005
    Publication date: January 22, 2009
    Inventors: Paul Bamborough, Sebastien Andre Campos, Vipulkumar Kantibhai Patel, Stephen Swanson, Ann Louise Walker
  • Aminopyrazine derivatives and compositions
    Patent number: 7459454
    Abstract: The present invention relates to aminopyrazine derivatives, compositions and medicaments containing the same, as well as processes for the preparation and use of such compounds, compositions and medcicaments. Such aminopyrazine derivatives are useful in the treatment of diseases associated with inappropriate tyrosine and/or serine/threonine kinase activity.
    Type: Grant
    Filed: March 18, 2004
    Date of Patent: December 2, 2008
    Assignee: SmithKline Beecham Corporation
    Inventors: Michael John Alberti, David Harold Drewry, David Drysdale Miller, Paul Bamborough
  • Indole Derivatives and Use Thereof as Kinase Inhibitors in Particular Ikk2 Inhibitors
    Publication number: 20080269200
    Abstract: Indole carboxamide compounds of Formula (I): are provided as inhibitors of kinase activity, in particular IKK2 activity as well as compositions and medicaments containing them, for use in inflammatory and tissue repair disorders.
    Type: Application
    Filed: January 13, 2005
    Publication date: October 30, 2008
    Applicant: SmithKline Beecham Corporation
    Inventors: Ian Robert Baldwin, Paul Bamborough, John Andrew Christopher, Jeffrey K Kerns, Timothy Longstaff, David Drysdale Miller
  • 5-Acylamino-1,1?-biphenyl-4-carboxamide derivatives and their use as P38 kinase inhibitors
    Patent number: 7432289
    Abstract: Compounds of formula (I): or pharmaceutically acceptable salts or solvates thereof, and their use as pharmaceuticals, particularly as p38 kinase inhibitors.
    Type: Grant
    Filed: October 16, 2002
    Date of Patent: October 7, 2008
    Assignee: Glaxo Group Limited
    Inventors: Richard Martyn Angell, Nicola Mary Aston, Paul Bamborough, Mark James Bamford, George Stuart Cockerill, Stephen Sean Flack, Dramane Ibrahim Lainé, Suzanne Joy Merrick, Kathryn Jane Smith, Ann Louise Walker
  • Heteroaryl substituted biphenyl derivatives as p38 kinase inhibitors
    Patent number: 7425555
    Abstract: Compounds of formula (I): are inhibitors of p38 kinase and are useful in the treatment of conditions or disease states mediated by p38 kinase activity or mediated by cytokines produced by the activity of p38.
    Type: Grant
    Filed: April 29, 2003
    Date of Patent: September 16, 2008
    Assignee: SmithKline Beecham Corporation
    Inventors: Richard Martyn Angell, Paul Bamborough, Ian Robert Baldwin, Anne-Marie Li-Kwai-Cheung, Timothy Longstaff, Suzanne Joy Merrick, Kathryn Jane Smith, Stephen Swanson, Ann Louise Walker
  • NOVEL COMPOUNDS
    Publication number: 20080176891
    Abstract: The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds according to formula (I): and salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular IKK2 activity.
    Type: Application
    Filed: September 20, 2007
    Publication date: July 24, 2008
    Inventors: Paul Bamborough, Michael David Barker, Sebastien Andre Campos, Richard Peter Charles Cousins, Paul Faulder, Heather Hobbs, Duncan Stuart Holmes, Michael John Johnston, John Liddle, Jeremy John Payne, John Martin Pritchard, Caroline Whitworth
  • 5?-carbamoyl-1,1?-biphenyl-4-carboxamide derivatives and their use as p38 kinase inhibitors
    Patent number: 7396843
    Abstract: Compounds of formula (I): or pharmaceutically acceptable salts or solvates thereof, and their use as pharmaceuticals, particularly as p38 kinase inhibitors.
    Type: Grant
    Filed: October 16, 2002
    Date of Patent: July 8, 2008
    Assignee: Glaxo Group Limited
    Inventors: Richard Martyn Angell, Nicola Mary Aston, Paul Bamborough, Mark James Bamford, George Stuart Cockerill, Suzanne Joy Merrick, Ann Louise Walker
  • NOVEL COMPOUNDS
    Publication number: 20080146606
    Abstract: The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds according to formula (I): and salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular IKK2 activity.
    Type: Application
    Filed: September 20, 2007
    Publication date: June 19, 2008
    Inventors: Paul Bamborough, Michael David Barker, Sebastien Andre Campos, Richard Peter Charles Cousins, Paul Faulder, Heather Hobbs, Duncan Stuart Holmes, Michael John Johnston, John Liddle, Jeremy John Payne, John Martin Pritchard, Caroline Whitworth
  • 2?-Methyl-5-(1,3,4-oxadiazol-2-yl)1, 1?-biphenyl-4-carboxaide derivatives and their use as p38 kinase
    Patent number: 7384963
    Abstract: Compounds of formula (I), wherein R1 is a phenyl group which may be optionally substituted; R2 is selected from hydrogen, C1-6 alkyl and (CH2)p—C3-7cycloalkyl; R3 is the group: (Formula II), R4 is selected from hydrogen and C1-4 alkyl; U is selected from methyl and halogen; X and Y are each selected independently from hydrogen, methyl and halogen; m is selected from 0, 1, 2, 3 and 4, and may be optionally substituted with up to two groups selected independently from C1-6 alkyl; n is selected from 0, 1 and 2; p is selected from 0, 1 and 2; or pharmaceutically acceptable salts or solvates thereof, and their use as pharmaceuticals, particularly as p38 kinase inhibitors
    Type: Grant
    Filed: October 16, 2002
    Date of Patent: June 10, 2008
    Assignee: Glaxo Group Limited
    Inventors: Richard Martyn Angell, Paul Bamborough, George Stuart Cockerill, Ann Louise Walker
  • Biphenylcarboxylic amide derivatives as p38 kinase inhibitors
    Patent number: 7309800
    Abstract: Compounds of formula (I): or pharmaceutically acceptable salts or solvates thereof, and their use as pharmaceuticals, particularly as p38 kinase inhibitors.
    Type: Grant
    Filed: November 3, 2006
    Date of Patent: December 18, 2007
    Assignee: Glaxo Group Limited
    Inventors: Richard Martyn Angell, Nicola Mary Aston, Paul Bamborough, Mark James Bamford, George Stuart Cockerill, Stephen Sean Flack, Dramane Ibrahim Lainé, Ann Louise Walker
  • Benzimidazol substituted thiopene derivatives with activity on ikk3
    Publication number: 20070149519
    Abstract: A compound of Formula (I): and compositions and medicaments containing the same, as well as processes for the preparation and use of such compounds, compositions and medicaments. Such benzimidazole derivatives are potentially useful in the treatment of diseases associated with inappropriate I-kappa-B kinase-3 (IKK3) (also known as I-kappa-B kinase epsilon (IKK?) or inducible I-kappa B kinase (IKKi)) activity.
    Type: Application
    Filed: February 7, 2005
    Publication date: June 28, 2007
    Inventors: Paul Bamborough, James Morey
  • Biphenyl-Derivatives as p38 Kinase Inhibitors
    Publication number: 20070142476
    Abstract: Compounds of formula (I): or pharmaceutically acceptable salts or solvates thereof, and their use as pharmaceuticals, particularly as p38 kinase inhibitors.
    Type: Application
    Filed: January 31, 2007
    Publication date: June 21, 2007
    Inventors: Richard Angell, Nicola Aston, Paul Bamborough, Mark Bamford, George Cockerill, Stephen Flack, Dramane Laine, Ann Walker
  • Biphenyl carboxylic amide p38 kinase inhibitors
    Publication number: 20070129354
    Abstract: Compound of formula (I): or pharmaceutically acceptable derivatives thereof, and their use as pharmaceuticals, particularly as p38 kinase inhibitors.
    Type: Application
    Filed: April 7, 2004
    Publication date: June 7, 2007
    Inventors: Nicola Aston, Paul Bamborough, Katherine Jones, Vipulkumar Patel, Stephen Swanson, Ann Walker