Abstract: The present disclosure provides human interleukin 4 receptor alpha antibody glucocorticoid receptor agonist conjugates and methods of using the conjugates for the treatment of inflammatory diseases, such as type 2 inflammatory diseases.

Abstract: A dosing unit for dosing fluids includes a fluid guiding module having a fluid inlet and a fluid outlet, a solenoid valve for controlling or regulating a fluid flow through the fluid guiding module, and a dosing tip, the fluid outlet of the fluid guiding module leading to the fluid inlet of the dosing tip, and the dosing tip having an elastic, self-closing outlet nozzle. Furthermore, a dosing station and a dosing tip are specified.

Abstract: Methods and system of traffic load balancing between a plurality of Points of Presence (PoP) of a cloud computing infrastructure are described. A first PoP of multiple PoPs of cloud computing infrastructure that provides a cloud computing service receives a packet. The packet includes as a destination address an anycast address advertised by the first PoP for reaching the cloud computing service. The first PoP identifies a network address of a second PoP that is different from the first PoP. The first PoP forwards the packets as an encapsulated packet to the second PoP to be processed in the second PoP according to the cloud computing service.

Abstract: A coated abrasive article includes a substrate and a plurality of abrasive particles overlying the substrate, and the plurality of abrasive particles including tapered abrasive particles having a taper fraction standard deviation of at least 0.025 and not greater than 0.090.

Abstract: Techniques for dynamic quarantine of impaired servers are described. A host monitor can obtain first monitoring data associated with a host computing device to at least one fingerprint. A host score associated with the host computing device can be updated based at least on the at least one fingerprint, the score determining a probability of the host computing device being used for a new job. Second monitoring data associated with the host computing device can be obtained following a reduction of load on the host computing device Following reduction in the load on the host, the score can be increased based on the at least one remediation action.

Abstract: Techniques for are described which enable users of a service provider network to manage local storage devices connected to computer systems of the service provider network as a service. A service provider network provides an application programming interface (API) that enables users to manage local storage devices in association with compute instances created by users using a hardware virtualization service of the service provider network. The API can be used to attach local storage devices to compute instances (that is, make local storage devices available for use as a block storage device), detach local storage devices from compute instances (that is, make local storage devices unavailable for use by a compute instance and possibly available for use by other compute instances on the same computer system), among other possible operations.

Abstract: An assembly (100) and method for bottoming feeding sheets from a stack of sheets to a top-feed sheet feeding mechanism (F) on a device (P), such as a copy machine. The assembly (100) includes a sheet feeder (200), a transport arm (300), and a final height adjustment block (420) translatably attached to and extending along the distal end (302) of the transport arm (300) for limited transverse (T) translation relative to the machine direction (MD).

Abstract: Remote computing resource service providers allow customers to execute virtual computer systems in a virtual environment on hardware provided by the computing resource service provider. The hardware may be distributed between various geographic locations connected by a network. The distributed environment may increase latency of various operations of the virtual computer systems executed by the customer. To reduce latency of various operations predictive modeling is used to predict the occurrence of various operations and initiate the operations before they may occur, thereby reducing the amount of latency perceived by the customer.

Abstract: Methods and apparatus for instance migration to support rapid recovery from correlated failures are described. A failure event affecting one or more compute instances of a provider network, including a particular compute instance hosted at a first instance host, is detected based on an analysis of health status information. A determination is made as to whether a particular compute instance meets an acceptance criterion for a failure-induced migration. The acceptance criterion may be based on storage-related requests from the particular compute instance. If the particular compute instance meets the acceptance criterion, one or more configuration operations are initiated to re-launch the particular compute instance at a different instance host.

Abstract: Remote computing resource service providers allow customers to execute virtual computer systems in a virtual environment on hardware provided by the computing resource service provider. The hardware may be distributed between various geographic locations connected by a network. The distributed environment may increase latency of various operations of the virtual computer systems executed by the customer. To reduce latency of various operations predictive modeling is used to predict the occurrence of various operations and initiate the operations before they may occur, thereby reducing the amount of latency perceived by the customer.

Abstract: Deployment feedback for updates to resources implemented in a private network may be implemented. Feedback codes may be generated and included in deployments sent to a private network for deployment at resources implemented in the private network. One or more of the included feedback codes may be selected based on the performance of the deployment and provided via a feedback communication channel that is disconnected and distinct from the private network. Once received, a current status of the deployment may be determined based on the one or more feedback codes provided via the feedback communication channel.

Abstract: A deployment approval system receives, from a deployment tool, a deployment request for performing a deployment to a particular resource. The deployment approval system can identify at least one rule for approving or rejecting the deployment request based on one or more criteria. The deployment approval system can determine whether the deployment request satisfies the one or more criteria in the at least one rule to approve or reject the request. If the deployment request is approved, the deployment approval system sends an approval to the deployment tool to perform the deployment. The deployment tool can then perform the deployment and, once the deployment is complete, the deployment approval system can receive a confirmation of the deployment. The deployment approval system can then store data describing the deployment in an audit repository.

Abstract: A provider network may implement compute instance migrations across availability zones. Compute instances may be located in a particular availability zone of provider network that is implemented across multiple availability zones. A request may be received, from a client of the provider network or other component of the provider network, to migrate a compute instance that is currently operating for a client and located in one availability zone to another availability zone. A destination compute instance may be provisioned in the other availability zone based on a configuration of the currently operating compute instance. In some embodiments, other computing resources utilized by the currently operating compute instance, such as data storage resources, may be moved to the other availability zone. Migration may be completed such that the destination compute instance is currently operating for the client and the compute instance is not.

Abstract: A ranking service can retrieve metrics from a metrics data store and use the metrics to determine a priority order in which to power down resources in a data center. Metrics from the data store can include a number of instances running on a host, a length of time that an instance has been operational, a type of instance, an amount of CPU use on a host, etc. The ranking service can also obtain other parameters from other sources. The parameters can include whether redundant or failover instances exist, the importance of the instances, whether the customer itself is considered important, other generic parameters from the customer account, a customer provided ranking of instances, etc.

Abstract: Computer systems, such as network computing resources systems, are subject to hardware and software errors. To improve error handling and troubleshooting, information relating to errors is collected from a multitude of computer system and analyzed. As a result of this analysis, troubleshooting errors in computer systems is improved and errors are remediated automatically.

Abstract: This is a machine to allow a single individual to manually wrap round hay bales with any type of film or net wrap. It allows the operator to position a round bale suspended on a bale spear and centered within the bale wrap ring to turn the ring which contains the wrap material clockwise or counterclockwise about the bale as the wrap covers the bale about its circumference. The ring can also be moved left and right to ensure full coverage of the bale in spite of widths and the ring is large enough to accommodate bales of any diameter up to six foot and can be easily adapted to bales of even larger diameter if round balers are produced in excess of six foot in diameter.

Abstract: A product metering apparatus (10) includes a first product conveyance mechanism (12) conveying product in a continuous stream. A platform (42) supports product and is movable along a closed path between a loading position adjacent to the first product conveyance mechanism (12) and a transfer position adjacent to an output in the form of a second product conveyance mechanism (22) spaced from the first product conveyance mechanism (12) in the conveying direction. The platform (42) in the loading position receives the product in the continuous stream from the first product conveyance mechanism (12) and is then accelerated to a speed greater than the first product conveyance mechanism (12) creating a gap between the product supported on the platform (42) and the product remaining in the continuous stream on the first product conveyance mechanism (12).

Abstract: This is a machine to allow a single individual to manually wrap round hay bales with any type of film or net wrap. It allows the operator to position a round bale suspended on a bale spear and centered within the bale wrap ring to turn the ring which contains the wrap material clockwise or counterclockwise about the bale as the wrap covers the bale about its circumference. The ring can also be moved left and right to ensure full coverage of the bale in spite of widths and the ring is large enough to accommodate bales of any diameter up to six foot and can be easily adapted to bales of even larger diameter if round balers are produced in excess of six foot in diameter.

Abstract: A product metering apparatus (10) includes a first product conveyance mechanism (12) conveying product in a continuous stream. A platform (42) supports product and is movable along a closed path between a loading position adjacent to the first product conveyance mechanism (12) and a transfer position adjacent to an output in the form of a second product conveyance mechanism (22) spaced from the first product conveyance mechanism (12) in the conveying direction. The platform (42) in the loading position receives the product in the continuous stream from the first product conveyance mechanism (12) and is then accelerated to a speed greater than the first product conveyance mechanism (12) creating a gap between the product supported on the platform (42) and the product remaining in the continuous stream on the first product conveyance mechanism (12).

Abstract: A system with an electromechanical lock, such as a vending machine, has a back up power supply for use in the event power failure and includes a sleep mode for a microcontroller associated with a vending machine. Specifically, a switch decouples the microcontroller from the battery when a power interruption is detected and thus inhibits most power draining functions. A sensor associated with the electromechanical lock detects the presence of a key and draws enough power from the battery to operate the electromechanical lock such that a key user may access the interior of the vending machine.