Abstract: Polypeptides comprising a C3b binding region are disclosed, as well as nucleic acids and vectors encoding such polypeptides, and cells and compositions comprising such polypeptides. Also disclosed arc uses and methods using the polypeptides for treating and preventing diseases and conditions.

Abstract: Polypeptides comprising a C3b binding region are disclosed, as well as nucleic acids and vectors encoding such polypeptides, and cells and compositions comprising such polypeptides. Also disclosed are uses and methods using the polypeptides for treating and preventing diseases and conditions.

Abstract: Polypeptides comprising a C3b binding region and a C3d inactivating region are disclosed, as well as nucleic acids and vectors encoding such polypeptides. Also disclosed are cells and compositions comprising such polypeptides, and uses and methods using the same.

Abstract: Methods for detecting and determining the level of complement proteins are disclosed, in particular using mass spectrometry. Also disclosed are methods of identifying subjects having or at risk of developing a complement-related disorder, and methods of treating the same.

Abstract: Methods of identifying subjects having complement-related disorders, or at risk of such disorders, are disclosed. Also disclosed are methods for selecting subjects for treatment with complement-targeted therapies, and methods of treatment of subjects with such therapies.

Abstract: Polypeptides comprising a C3b binding region are disclosed, as well as nucleic acids and vectors encoding such polypeptides, and cells and compositions comprising such polypeptides. Also disclosed are uses and methods using the polypeptides for treating and preventing diseases and conditions.

Abstract: Polypeptides comprising a C3b binding region are disclosed, as well as nucleic acids and vectors encoding such polypeptides, and cells and compositions comprising such polypeptides. Also disclosed are uses and methods using the polypeptides for treating and preventing diseases and conditions.

Abstract: Polypeptides comprising a C3b binding region are disclosed, as well as nucleic acids and vectors encoding such polypeptides, and cells and compositions comprising such polypeptides. Also disclosed are uses and methods using the polypeptides for treating and preventing diseases and conditions.

Abstract: A method of manufacturing building-wall flexible cladding (12) for a wall of a building so that a cladding outer surface of the building-wall flexible cladding (12) matches or substantially matches a textured wall surface of the wall of the building. This is first achieved by selecting the wall to be modelled (S101) and forming an impression of the wall (S102). An absorbent flexible substrate (18) is provided (S103), and a wet mixture (24) created (S105) and applied to the substrate (18, S106) to form one or more tiles (24a). The wet mixture (24) is textured by applying the impression so that the cladding outer surface corresponds or substantially corresponds to the said textured wall surface (S108). Finally, the textured wet mixture is cured (S109).

Abstract: The present invention relates to an improved method of providing photoreceptor function to a cell, for example for use in the treatment of retinal degeneration. The present invention also relates to compositions and kits, in particular for use in such methods.

Abstract: Methods for determining whether a subject is at risk of developing a complement-related disorder are disclosed. Also disclosed are complement-targeted therapeutics for treating a complement-related disorder, in particular agents that decrease the level of FHR-4.

Abstract: A method of manufacturing building-wall flexible cladding (12) for a wall of a building so that a cladding outer surface of the building-wall flexible cladding (12) matches or substantially matches a textured wall surface of the wall of the building. This is first achieved by selecting the wall to be modelled (S101) and forming an impression of the wall (S102). An absorbent flexible substrate (18) is provided (S103), and a wet mixture (24) created (S105) and applied to the substrate (18, S106) to form one or more tiles (24a). The wet mixture (24) is textured by applying the impression so that the cladding outer surface corresponds or substantially corresponds to the said textured wall surface (S108). Finally, the textured wet mixture is cured (S109).

Abstract: Polypeptides comprising a C3b binding region are disclosed, as well as nucleic acids and vectors encoding such polypeptides, and cells and compositions comprising such polypeptides. Also disclosed are uses and methods using the polypeptides for treating and preventing diseases and conditions.

Abstract: The present invention relates to an improved method of providing photoreceptor function to a cell, for example for use in the treatment of retinal degeneration. The present invention also relates to compositions and kits, in particular for use in such methods.

Abstract: Polypeptides comprising a C3b binding region and a C3d inactivating region are disclosed, as well as nucleic acids and vectors encoding proteolytic such polypeptides. Also disclosed are cells and compositions comprising such polypeptides, and uses and methods using the same.

Abstract: An improved handrail for a staircase or ramp. In one embodiment, the handrail includes an elongated member such as a cylinder or bar that spans the length of the staircase or ramp and a riser barrier. The riser barrier has an extender portion and a riser portion. The extender portion of the riser barrier keeps the elongated member a sufficient distance horizontally from the riser portion that a person can slide his or her hand on the rail without interference. The riser portion projects vertically a sufficient distance above the elongated member to deter sliding down the elongated member. Thus, sliding on the member is deterred, while the function of the cylinder as a handrail is preserved.

Abstract: An improved handrail for a staircase or ramp. In one embodiment, the handrail includes an elongated member such as a cylinder or bar that spans the length of the staircase or ramp and a riser barrier. The riser barrier has an extender portion and a riser portion. The extender portion of the riser barrier keeps the elongated member a sufficient distance horizontally from the riser portion that a person can slide his or her hand on the rail without interference. The riser portion projects vertically a sufficient distance above the elongated member to deter sliding down the elongated member. Thus, sliding on the member is deterred, while the function of the cylinder as a handrail is preserved.

Abstract: A flexible cladding wrap (10) for an exterior or interior wall of a building, a building wall panel, and/or a building surface is provided, the flexible cladding wrap (10) comprising a flexible facing layer (16) including a, preferably absorbent and more preferably porous, flexible facing substrate (22) and powdered aggregate (24) bonded to the facing substrate (22); and a flexible backing layer (12) including a flexible backing substrate (20) to which the facing layer is attached. A system utilizing said flexible cladding wrap (10) to create a continuous aesthetic impression of the building is also provided, in addition to methods of making and using said flexible cladding wrap (10).

Abstract: An improved handrail for a staircase or ramp. In one embodiment, the handrail includes an elongated member such as a cylinder or bar that spans the length of the staircase or ramp and a riser barrier. The riser barrier has an extender portion and a riser portion. The extender portion of the riser barrier keeps the elongated member a sufficient distance horizontally from the riser portion that a person can slide his or her hand on the rail without interference. The riser portion projects vertically a sufficient distance above the elongated member to deter sliding down the elongated member. Thus, sliding on the member is deterred, while the function of the cylinder as a handrail is preserved.

Abstract: An improved handrail for a staircase or ramp. In one embodiment, the handrail includes an elongated member such as a cylinder or bar that spans the length of the staircase or ramp and a riser barrier. The riser barrier has an extender portion and a riser portion. The extender portion of the riser barrier keeps the elongated member a sufficient distance horizontally from the riser portion that a person can slide his or her hand on the rail without interference. The riser portion projects vertically a sufficient distance above the elongated member to deter sliding down the elongated member. Thus, sliding on the member is deterred, while the function of the cylinder as a handrail is preserved.