Abstract: Microbial cell lines suitable for industrial-scale production of organic acids and methods of making and isolating such cell lines.

Abstract: Microbial cell lines suitable for industrial-scale production of organic acids and methods of making and isolating such cell lines.

Abstract: This disclosure describes methods that allow for the uncoupling of microbial growth from product formation, which allows for maximal use of raw material and optimal end-product formation.

Abstract: An engineered payload-delivery system includes a target cell binding unit, covalently bound to a pore forming unit, and a payload portion adapted with a region capable of non-covalently binding to the pore forming unit. The pore forming unit is derived from a particular sub-serotype of Clostridium toxin, while the payload region is derived from a different sub-serotype of Clostridium toxin. The disclosed chimeric protein-based composition is capable of specifically delivering payload to neural cells.

Abstract: Microbial cell lines suitable for industrial-scale production of organic acids and methods of making and isolating such cell lines.

Abstract: Microbial cell lines suitable for industrial-scale production of organic acids and methods of making and isolating such cell lines.

Abstract: An engineered payload-delivery system includes a target cell binding unit, covalently bound to a pore forming unit, and a payload portion adapted with a region capable of non-covalently binding to the pore forming unit. The pore forming unit is derived from a particular sub-serotype of Clostridium toxin, while the payload region is derived from a different sub-serotype of Clostridium toxin. The disclosed chimeric protein-based composition is capable of specifically delivering payload to neural cells.

Abstract: An engineered payload-delivery system includes a target cell binding unit, covalently bound to a pore forming unit, and a payload portion adapted with a region capable of non-covalently binding to the pore forming unit. The pore forming unit is derived from a particular sub-serotype of Clostridium toxin, while the payload region is derived from a different sub-serotype of Clostridium toxin. The disclosed chimeric protein-based composition is capable of specifically delivering payload to neural cells.

Abstract: Microbial cell lines suitable for industrial-scale production of organic acids and methods of making and isolating such cell lines.

Abstract: An engineered payload-delivery system includes a target cell binding unit, covalently bound to a pore forming unit, and a payload portion adapted with a region capable of non-covalently binding to the pore forming unit. The pore forming unit is derived from a particular sub-serotype of Clostridium toxin, while the payload region is derived from a different sub-serotype of Clostridium toxin. The disclosed chimeric protein-based composition is capable of specifically delivering payload to neural cells.

Abstract: This disclosure describes methods that allow for the uncoupling of microbial growth from product formation, which allows for maximal use of raw material and optimal end-product formation.

Abstract: One or more network elements that modify type of service values in a network are detected by sending route tracing messages having increasing time-to-live values and a designated type of service value from a first network element to a second network element. Type of service values are monitored in respective time exceeded messages received from respective network elements on a given network path between the first network element and the second network element responsive to the route tracing messages. At least a particular one of the network elements on the given network path that has made a modification in type of service value relative to the designated type of service value is identified, based on the monitored type of service values in the respective time exceeded messages.

Abstract: A technique for ensuring that a node that carries high-priority protocol data units and low-priority protocol data units is properly configured to accord the high-level protocol data units priority treatment is described. In accordance with the illustrative embodiment, two streams of protocol data units are transmitted through a node to be tested. One stream comprises high-priority protocol data units, and the second stream comprises low-priority protocol data units. The processing capabilities of the node are then burdened by increasing the frequency of protocol data units transmitted to it, so that the node is compelled to treat the two streams differently, if, in fact, it is properly configured to treat them differently. If the node treats the two streams differently and accords the high-priority stream higher priority, then the node is properly configured. Otherwise, the node is re-configured to accord the high-priority stream higher priority.

Abstract: A technique for ensuring that a node that carries high-priority protocol data units and low-priority protocol data units is properly configured to accord the high-level protocol data units priority treatment is described. In accordance with the illustrative embodiment, two streams of protocol data units are transmitted through a node to be tested. One stream comprises high-priority protocol data units, and the second stream comprises low-priority protocol data units. The processing capabilities of the node are then burdened by increasing the frequency of protocol data units transmitted to it, so that the node is compelled to treat the two streams differently, if, in fact, it is properly configured to treat them differently. If the node treats the two streams differently and accords the high-priority stream higher priority, then the node is properly configured. Otherwise, the node is re-configured to accord the high-priority stream higher priority.

Abstract: One or more network elements that modify type of service values in a network are detected by sending route tracing messages having increasing time-to-live values and a designated type of service value from a first network element to a second network element. Type of service values are monitored in respective time exceeded messages received from respective network elements on a given network path between the first network element and the second network element responsive to the route tracing messages. At least a particular one of the network elements on the given network path that has made a modification in type of service value relative to the designated type of service value is identified, based on the monitored type of service values in the respective time exceeded messages.

Abstract: The present invention is directed to use of hyperthermophilic enzymes for industrial chemical redox reactions such as ethanol production. The present invention is especially useful for the coupled synthesis and recovery of alcohols whereby recovery of alcohol is simplified.

Abstract: A novel method for examining bacterial growth state is carried out by measuring the levels of conserved cytosolic proteins specific for alternative growth states, using bacterial specific antibody fluorochrome-coupled probe. Utilizing the method of the invention, the cellular growth state of individual bacteria can be determined by measuring the abundance of growth state-specific protein homologs. For example, through use of the protein profiling method of the invention, bacterial VNC state can be distinguished by differentiating growing (exponential phase) from nongrowing or dormant (stationary phase) cells.

Abstract: Recombinant, thermostable alpha-glucosidases from archaeal micro-organisms and isolated DNA encoding for such alpha-glucosidases are provided. The isolated DNA is obtained by use of DNA or antibody probes prepared from the DNA encoding S. sulfataricus alpha-glucosidase. Also provided are methods for producing recombinant archaeal thermostable alpha-glucosidase and transformants incorporating thermostable alpha-glucosidase. Autoprocessing of plant tissue through the use of transgenic thermostable glycosyl hydrolases is described.

Abstract: The present invention is directed to use of hyperthermophilic enzymes for industrial chemical redox reactions such as ethanol production. The present invention is especially useful for the coupled synthesis and recovery of alcohols whereby recovery of alcohol is simplified.

Abstract: A stowage rack is disclosed for dry transport of nuclear fuel elements in a plurality of elongated, parallel, adjacent prismatic cells. The rack is formed from first and second sets of materials, the first set of materials fulfilling the function of mechanical strength and thermal conductivity, and the second set of materials fulfilling the function of neutron absorption. The stack may be formed entirely of materials fulfilling the function of mechanical strength and thermal conductivity, with the neutron absorption materials being provided within the walls of the cells. Alternatively, materials providing mechanical strength and thermal conductivity may be stacked alternately with materials providing neutron absorption.