Patents by Inventor Paul Bottomley
Paul Bottomley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10908235Abstract: A method of spatially imaging a nuclear magnetic resonance (NMR)parameter whose measurement requires the acquisition of spatially localized NMR signals in a sample includes placing the sample in an MRI apparatus with a plurality of MRI detectors each having a spatial sensitivity map; and applying MRI sequences adjusted to be sensitive to the NMR parameter. At least one of the MRI sequences is adjusted so as to substantially fully sample an image k-space of the sample. The remainder of the MRI sequences is adjusted to under-sample the image k-space. The method further includes acquiring image k-space NMR signal datasets; estimating a sensitivity map of each of the MRI detectors using a strategy to suppress unfolding artefacts; and applying the estimated sensitivity maps to at least one of the image k-space NMR signal data sets to reconstruct a spatial image of NMR signals that are sensitive to the NMR parameter.Type: GrantFiled: April 7, 2017Date of Patent: February 2, 2021Assignee: The Johns Hopkins UniversityInventors: Yi Zhang, Jinyuan Zhou, Paul A. Bottomley
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Patent number: 10548505Abstract: A magnetic resonance method and system are provided for magnetic resonance (MR) image-guided insertion of an object into a biological tissue along a predetermined trajectory. The trajectory provides a path between a starting point and a target site within the tissue. Sufficiently high resolution images can be generated in real time to precisely guide the needle placement. A compressed sensing approach is used to generate the images based on minimization of a cost function, where the cost function is based on the predetermined needle path, artifact effects associated with the needle, the negligible changes in the images away from the trajectory, and the limited differences between successive images. The improved combination of spatial and temporal resolution facilitates an insertion procedure that can be continuously adjusted to accurately follow a predetermined trajectory in the tissue, without interruptions to obtain verification images.Type: GrantFiled: March 15, 2016Date of Patent: February 4, 2020Assignees: Siemens Healthcare GmbH, The Johns Hopkins UniversityInventors: Eva Rothgang, Arne Hengerer, Lars Lauer, Jan Fritz, Paul Bottomley, Wesley David Gilson, Robert Grimm
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Patent number: 10459045Abstract: Sterile RF coil arrangements for use in magnetic resonance imaging are provided. The sterile coil arrangements can be formed by spraying or coating a curable liquid onto an RF coil housing and allowing the liquid to cure or dry to form a continuous sterile layer on the coil housing. The thickness of the sterile layer can be between 100 and 1000 micrometers. The curable liquid can include an antimicrobial or antibacterial agent, such as silver ions or triclosan, to better maintain sterility of the coil arrangement. The curable liquid can be selected such that it adheres to the housing when cured and is also removable without leaving residue behind.Type: GrantFiled: March 28, 2016Date of Patent: October 29, 2019Assignees: Siemens Healthcare GmbH, The Johns Hopkins UniversityInventors: Arne Hengerer, Eva Rothgang, Lars Lauer, Jonathan Lewin, Jan Fritz, Clifford Weiss, Katarzyna J. Macura, Paul Bottomley, Wesley David Gilson
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Patent number: 10391307Abstract: RF/MRI compatible leads include at least one conductor that turns back on itself at least twice in a lengthwise direction, and can turn back on itself at least twice at multiple locations along its length. The at least one electrical lead can be configured so that the lead heats local tissue less than about 10 degrees Celsius (typically about 5 degrees Celsius or less) or does not heat local tissue when a patient is exposed to target RF frequencies at a peak input SAR of at least about 4 W/kg and/or a whole body average SAR of at least about 2 W/kg. Related devices and methods of fabricating leads are also described.Type: GrantFiled: November 15, 2016Date of Patent: August 27, 2019Assignees: Boston Scientific Neuromodulation Corporation, MRI Interventions, Inc.Inventors: Paul A. Bottomley, Parag V. Karmarkar, Justin M. Allen, William A. Edelstein
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Patent number: 10292615Abstract: A method of internal MRI employing at least one active internal MRI detector located within a sample of interest. The method includes applying an MRI pulse sequence to the sample of interest. The MRI pulse sequence includes spatial encoding projections. The method further includes receiving MRI signals at the active internal MRI detector and reconstructing at least one MRI image from the MRI signals using an error minimizing algorithm. The MRI pulse sequence provides an increase in an acquisition speed when reconstructing the at least one MRI image by sparsely under-sampling an image k-space in at least one dimension.Type: GrantFiled: September 20, 2013Date of Patent: May 21, 2019Assignee: THE JOHNS HOPKINS UNIVERSITYInventors: Paul Bottomley, Yi Zhang, Shashank S. Hegde
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Publication number: 20190101603Abstract: A method of spatially imaging a nuclear magnetic resonance (NMR)parameter whose measurement requires the acquisition of spatially localized NMR signals in a sample includes placing the sample in an MRI apparatus with a plurality of MRI detectors each having a spatial sensitivity map; and applying MRI sequences adjusted to be sensitive to the NMR parameter. At least one of the MRI sequences is adjusted so as to substantially fully sample an image k-space of the sample. The remainder of the MRI sequences is adjusted to under-sample the image k-space. The method further includes acquiring image k-space NMR signal datasets; estimating a sensitivity map of each of the MRI detectors using a strategy to suppress unfolding artefacts; and applying the estimated sensitivity maps to at least one of the image k-space NMR signal data sets to reconstruct a spatial image of NMR signals that are sensitive to the NMR parameter.Type: ApplicationFiled: April 7, 2017Publication date: April 4, 2019Inventors: Yi ZHANG, Jinyuan ZHOU, Paul A. BOTTOMLEY
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Patent number: 10209330Abstract: A method of performing spatially localized magnetic resonance spectroscopy includes receiving a magnetic resonance image of an object; identifying a plurality C of compartments that generate magnetic resonance spectroscopy signals in the object including at least one compartment of interest; segmenting in at least one spatial dimension the magnetic resonance image of the object into the C compartments; acquiring magnetic resonance spectroscopy signals from the compartments by applying a plurality of M? phase encodings applied in the at least one spatial dimension, wherein M??C; calculating a spatially localized magnetic resonance chemical shift spectrum from the at least one compartment of interest; and rendering a spatially localized magnetic resonance spectrum that is substantially equal to a spatial average of magnetic resonance chemical shift spectra from the at least one compartment of interest. A magnetic resonance spectroscopy and imaging system is configured to perform the above method.Type: GrantFiled: March 22, 2012Date of Patent: February 19, 2019Assignee: The Johns Hopkins UniversityInventors: Paul A. Bottomley, Refaat Gabr, Yi Zhang, Robert G. Weiss
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Patent number: 10209325Abstract: A configurable coil arrangement for use with MRI-guided procedures is provided that facilitates optimal imaging for both pre-procedure planning and imaging of the target sites during the procedure. The coil arrangement includes a plurality of connected coil elements. Spacers connecting the coil elements can be adjustable and/or deformable to provide one or more openings in the coil arrangement of optimal size for accessing the subject within the imaged region. Individual coil elements can also be removed to provide access openings during such procedures, or left in the array for improved pre- and post-procedure image quality. The MRI system can be configured to detect configurations of the coil arrangement and modify imaging parameters to optimize image quality.Type: GrantFiled: February 29, 2016Date of Patent: February 19, 2019Assignees: Siemens Healthcare GmbH, The Johns Hopkins UniversityInventors: Eva Rothgang, Volker Matschl, Arne Hengerer, Lars Lauer, Wesley David Gilson, Jonathan Lewin, Jan Fritz, Clifford Weiss, Katarzyna Macura, Paul Bottomley
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Patent number: 10180469Abstract: A magnetic resonance imaging system and method are provided that include user control of certain functions using physical gestures, such as hand motions or the like. The gesture control aspects can include one or more cameras, and a processor configured to detect and recognize gestures corresponding to predetermined commands and to provide signals to execute the commands. A verification switch, such as a foot switch, can be included to improve safety and reliability of the gesture control aspects. This switch can be used to activate the gesture detection aspects and/or to confirm a recognized gesture command prior to its execution.Type: GrantFiled: October 28, 2015Date of Patent: January 15, 2019Assignees: Siemens Healthcare GmbH, The John Hopkins UniversityInventors: Arne Hengerer, Eva Rothgang, Lars Lauer, Jonathan Lewin, Wesley David Gilson, Jan Fritz, Clifford R. Weiss, Katarzyna J. Macura, Paul A. Bottomley
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Patent number: 10120049Abstract: An NMR method and system for acquiring and reconstructing a value of an NMR parameter spatially localized to a compartment of interest including performing a first MM of a portion of a sample with a first MRI pulse sequence using the NMR system and using a set of k-space spatial encoding gradients or coil sensitivity encoding maps to obtain a first magnetic resonance image to identify a compartment of interest; generating a second MRI pulse sequence that encodes the NMR parameter with a subset of the set of k-space spatial encoding gradients or the coil sensitivity encoding maps; applying the second MRI pulse sequence using the NMR system to acquire spatial information relating to the NMR parameter from the compartment of interest; segmenting the first magnetic resonance image into a plurality of compartments that includes the compartment of interest; and reconstructing a value of the NMR parameter in the compartment.Type: GrantFiled: May 18, 2015Date of Patent: November 6, 2018Assignee: The Johns Hopkins UniversityInventors: Yi Zhang, Jinyuan Zhou, Paul A. Bottomley
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Patent number: 9791489Abstract: A device with at least one channel for measuring high dynamic range, radio frequency (RF) power levels over broad-ranging duty cycles includes a power sensor circuit comprising at least one logarithmic amplifier; at least one directional RF coupler electrically connected to the at least one power sensor; at least one RF attenuator electrically connected to the at least one RF coupler; and at least one sampling circuit electrically connected to the at least one RF attenuator and the at least one RF coupler. The at least one sampling circuit performs analog-to-digital conversion of electrical signals received to provide digitals signals for measuring the RF power level in the at least one channel.Type: GrantFiled: March 22, 2012Date of Patent: October 17, 2017Assignee: THE JOHNS HOPKINS UNIVERSITYInventors: Paul A. Bottomley, William Edelstein, Abdel-Monem M. El-Sharkawy, Di Qian
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Publication number: 20170276742Abstract: Sterile RF coil arrangements for use in magnetic resonance imaging are provided. The sterile coil arrangements can be formed by spraying or coating a curable liquid onto an RF coil housing and allowing the liquid to cure or dry to form a continuous sterile layer on the coil housing. The thickness of the sterile layer can be between 100 and 1000 micrometers. The curable liquid can include an antimicrobial or antibacterial agent, such as silver ions or triclosan, to better maintain sterility of the coil arrangement. The curable liquid can be selected such that it adheres to the housing when cured and is also removable without leaving residue behind.Type: ApplicationFiled: March 28, 2016Publication date: September 28, 2017Inventors: Arne Hengerer, Eva Rothgang, Lars Lauer, Jonathan Lewin, Jan Fritz, Clifford Weiss, Katarzyna J. Macura, Paul Bottomley, Wesley David Gilson
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Publication number: 20170269174Abstract: A magnetic resonance method and system are provided for magnetic resonance (MR) image-guided insertion of an object into a biological tissue along a predetermined trajectory. The trajectory provides a path between a starting point and a target site within the tissue. Sufficiently high resolution images can be generated in real time to precisely guide the needle placement. A compressed sensing approach is used to generate the images based on minimization of a cost function, where the cost function is based on the predetermined needle path, artifact effects associated with the needle, the negligible changes in the images away from the trajectory, and the limited differences between successive images. The improved combination of spatial and temporal resolution facilitates an insertion procedure that can be continuously adjusted to accurately follow a predetermined trajectory in the tissue, without interruptions to obtain verification images.Type: ApplicationFiled: March 15, 2016Publication date: September 21, 2017Inventors: Eva Rothgang, Arne Hengerer, Lars Lauer, Jan Fritz, Paul Bottomley, Wesley David Gilson, Robert Grimm
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Publication number: 20170248666Abstract: A configurable coil arrangement for use with MRI-guided procedures is provided that facilitates optimal imaging for both pre-procedure planning and imaging of the target sites during the procedure. The coil arrangement includes a plurality of connected coil elements. Spacers connecting the coil elements can be adjustable and/or deformable to provide one or more openings in the coil arrangement of optimal size for accessing the subject within the imaged region. Individual coil elements can also be removed to provide access openings during such procedures, or left in the array for improved pre- and post-procedure image quality. The MRI system can be configured to detect configurations of the coil arrangement and modify imaging parameters to optimize image quality.Type: ApplicationFiled: February 29, 2016Publication date: August 31, 2017Inventors: Eva Rothgang, Volker Matschl, Arne Hengerer, Lars Lauer, Wesley David Gilson, Jonathan Lewin, Jan Fritz, Clifford Weiss, Katarzyna Macura, Paul Bottomley
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Publication number: 20170123030Abstract: A magnetic resonance imaging system and method are provided that include user control of certain functions using physical gestures, such as hand motions or the like. The gesture control aspects can include one or more cameras, and a processor configured to detect and recognize gestures corresponding to predetermined commands and to provide signals to execute the commands. A verification switch, such as a foot switch, can be included to improve safety and reliability of the gesture control aspects. This switch can be used to activate the gesture detection aspects and/or to confirm a recognized gesture command prior to its execution.Type: ApplicationFiled: October 28, 2015Publication date: May 4, 2017Inventors: Arne Hengerer, Eva Rothgang, Lars Lauer, Jonathan Lewin, Wesley David Gilson, Jan Fritz, Clifford R. Weiss, Katarzyna J. Macura, Paul A. Bottomley
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Publication number: 20170113036Abstract: RF/MRI compatible leads include at least one conductor that turns back on itself at least twice in a lengthwise direction, and can turn back on itself at least twice at multiple locations along its length. The at least one electrical lead can be configured so that the lead heats local tissue less than about 10 degrees Celsius (typically about 5 degrees Celsius or less) or does not heat local tissue when a patient is exposed to target RF frequencies at a peak input SAR of at least about 4 W/kg and/or a whole body average SAR of at least about 2 W/kg. Related devices and methods of fabricating leads are also described.Type: ApplicationFiled: November 15, 2016Publication date: April 27, 2017Inventors: Paul A. Bottomley, Parag V. Karmarkar, Justin M. Allen, William A. Edelstein
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Methods and apparatus for fabricating leads with conductors and related flexible lead configurations
Patent number: 9630000Abstract: MRI/RF compatible leads include at least one conductor, a respective conductor having at least one segment with a multi-layer stacked coil configuration. The lead can be configured so that the lead heats local tissue less than about 10 degrees Celsius (typically about 5 degrees Celsius or less) or does not heat local tissue when a patient is exposed to target RF frequencies at a peak input SAR of at least about 4 W/kg and/or a whole body average SAR of at least about 2 W/kg. Related leads and methods of fabricating leads are also described.Type: GrantFiled: February 1, 2016Date of Patent: April 25, 2017Assignees: Boston Scientific Neuromodulation Corporation, MRI Interventions, Inc.Inventors: Paul A. Bottomley, Parag V. Karmarkar, Justin M. Allen, William A. Edelstein, Peter Piferi, Brian Gore -
Publication number: 20160341808Abstract: An NMR method and system for acquiring and reconstructing a value of an NMR parameter spatially localized to a compartment of interest including performing a first MM of a portion of a sample with a first MRI pulse sequence using the NMR system and using a set of k-space spatial encoding gradients or coil sensitivity encoding maps to obtain a first magnetic resonance image to identify a compartment of interest; generating a second MRI pulse sequence that encodes the NMR parameter with a subset of the set of k-space spatial encoding gradients or the coil sensitivity encoding maps; applying the second MRI pulse sequence using the NMR system to acquire spatial information relating to the NMR parameter from the compartment of interest; segmenting the first magnetic resonance image into a plurality of compartments that includes the compartment of interest; and reconstructing a value of the NMR parameter in the compartment.Type: ApplicationFiled: May 18, 2015Publication date: November 24, 2016Inventors: Yi Zhang, Jinyuan Zhou, Paul A. Bottomley
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Patent number: 9494668Abstract: A system for measuring nuclear magnetic resonance spin-lattice relaxation time T1 and spin-spin relaxation time T2 of a sample includes a source of a substantially uniform magnetic field B0 for immersing at least a portion of the sample; a nuclear magnetic resonance excitation and detection system constructed and arranged to excite at least a portion of the sample with a plurality of nuclear magnetic resonance pulse sequences, each applied with a repetition time that is preselected to be sensitive to a T1 value of at least a portion of the sample, and to detect nuclear magnetic resonance emissions from the sample in response to excitations to provide a plurality of detection signals; and a signal processing system configured to communicate with the nuclear magnetic resonance excitation and detection system to receive the plurality of detection signals.Type: GrantFiled: December 3, 2012Date of Patent: November 15, 2016Assignee: THE JOHNS HOPKINS UNIVERSITYInventors: Paul A. Bottomley, Guan Wang, Abdel-Monem M. El-Sharkawy
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Patent number: 9492651Abstract: RF/MRI compatible leads include at least one conductor that turns back on itself at least twice in a lengthwise direction, and can turn back on itself at least twice at multiple locations along its length. The at least one electrical lead can be configured so that the lead heats local tissue less than about 10 degrees Celsius (typically about 5 degrees Celsius or less) or does not heat local tissue when a patient is exposed to target RF frequencies at a peak input SAR of at least about 4 W/kg and/or a whole body average SAR of at least about 2W/kg. Related devices and methods of fabricating leads are also described.Type: GrantFiled: March 13, 2008Date of Patent: November 15, 2016Assignees: MRI Interventions, Inc., Boston Scientific Neuromodulation CorporationInventors: Paul A. Bottomley, Parag V. Karmarkar, Justin M. Allen, William A. Edelstein