Abstract: Surgical tools and assemblies are employed for use in minimally invasive surgical (MIS) procedures. A surgical tool assembly includes a handle assembly and a frame assembly. The handle assembly and frame assembly are designed and constructed to have an articulation input joint and a grounding joint between them. A pitch rotational degree of freedom and a yaw rotational degree of freedom are provided by way of the articulation input joint. The handle assembly is translationally constrained relative to the frame assembly by way of the grounding joint. Intermediate bodies and joints can be provided in certain surgical tool assemblies and architectures.

Abstract: This invention relates to a crystalline form of (10R)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]benzoxadiazacyclo-tetradecine-3-carbonitrile (lorlatinib) free base hydrate (Form 24). This invention also relates to pharmaceutical compositions comprising Form 24, and to methods of using Form 24 and such compositions in the treatment of abnormal cell growth, such as cancer, in a mammal.

Abstract: A rotary seal comprises a seal element comprising a disc-shaped body having a first axial side and an opposed second axial side. The seal element further comprises a radially inner central circular opening for receiving a rotary shaft, the opening having an inner periphery for sealing engagement with the shaft. A radially outer rim portion of the seal element comprises an axially facing annular sealing surface provided on the first axial side for sealing engagement in use with an opposed axially facing sealing surface of an adjacent first static housing and an axially facing pocket provided on the second axial side and having an axially facing surface for receiving, in use, an annular elastomeric biasing element. At least one drainage passage is formed through the outer rim portion from an inlet on the second axial side to an outlet on a radially outer portion of the rim portion.

Abstract: Disclosed is a method for monitoring cell density during cell expansion resulting from a cell culture process in a bioreactor comprising the steps of: a) cultivating cells in a bioreactor culture chamber according to a cell culture process having cell culture parameters; b) during said process, introducing cell culture fluid inputs and generating waste materials; c) determining the amount of volatile organic compounds (VOCs) and their chemical species in the waste materials; and d) estimating the density or population of cells in the bioreactor based on said determination.

Abstract: This invention relates to a crystalline form of (10R)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahy-dro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]benzoxadiazacyclo-tetradecine-3-carbonitrile (lorlatinib) free base hydrate (Form 24). This invention also relates to pharmaceutical compositions comprising Form 24, and to methods of using Form 24 and such compositions in the treatment of abnormal cell growth, such as cancer, in a mammal.

Abstract: A rotary seal comprises a seal element comprising a disc-shaped body having a first axial side and an opposed second axial side. The seal element further comprises a radially inner central circular opening for receiving a rotary shaft, the opening having an inner periphery for sealing engagement with the shaft. A radially outer rim portion of the seal element comprises an axially facing annular sealing surface provided on the first axial side for sealing engagement in use with an opposed axially facing sealing surface of an adjacent first static housing and an axially facing pocket provided on the second axial side and having an axially facing surface for receiving, in use, an annular elastomeric biasing element. At least one drainage passage is formed through the outer rim portion from an inlet on the second axial side to an outlet on a radially outer portion of the rim portion.

Abstract: A system is provided for controlling automatic brake systems to avoid pulsing vehicle brakes at certain natural vibration frequencies of the vehicle's mechanical systems such as a powertrain and driveline. The natural vibration frequencies of the vehicle's systems are determined and correlated with a range of possible braking regimes implemented by an on-board automatic brake control, such as an anti-lock braking (ABS) system. A proposed, normally appropriate ABS braking response to a sudden braking condition is either modified, accelerated or delayed when the proposed response is deemed likely to excite a vehicle natural frequency. The system improves ABS operation in vehicles having high effective inertia powertrains, such as those used in hybrid electric vehicles.

Abstract: A system is provided for controlling the inertia of a vehicle's powertrain during sudden braking events. Torque generated by rapid deceleration of the vehicle's drive wheels during braking is prevented from being transmitted through the vehicle's driveline by a clutch which disengages the drive wheels from high effective inertia components in the driveline. The clutch is actuated by a signal produced by any of several sensors on the vehicle which sense a sudden braking event. Driveline speed is adjusted to match drive wheel speed before the clutch is deactivated to reengage driveline with the drive wheels.

Abstract: A system is provided for controlling the inertia of a vehicle's powertrain during sudden braking events. Torque generated by rapid deceleration of the vehicle's drive wheels during braking is prevented from being transmitted through the vehicle's driveline by a clutch which disengages the drive wheels from high effective inertia components in the driveline. The clutch is actuated by a signal produced by any of several sensors on the vehicle which sense a sudden braking event. Driveline speed is adjusted to match drive wheel speed before the clutch is deactivated to reengage driveline with the drive wheels.

Abstract: A control system limits reactive torque in a powertrain that is generated when braking force is applied to traction wheels during a sudden stop or other sudden braking event. The reactive torque generated at the traction wheels is prevented from being transmitted upstream through the driveline and powertrain by using a slip type clutch in the driveline to limit the upstream transfer of the reactive wheel torque. The clutch is directly actuated by the reactive torque and therefore does not require special controls or monitoring systems to sense the braking event. The clutch pressure may be automatically adjusted in response to certain operating conditions or events, thereby adjusting the point at which the clutch begins to slip due to reactive wheel torque.

Abstract: A system is provided for controlling the inertia of a vehicle's powertrain during sudden braking events. Torque generated by rapid deceleration of the vehicle's drive wheels during braking is prevented from being transmitted through the vehicle's driveline by a clutch which disengages the drive wheels from high effective inertia components in the driveline. The clutch is actuated by a signal produced by any of several sensors on the vehicle which sense a sudden braking event. Driveline speed is adjusted to match drive wheel speed before the clutch is deactivated to reengage driveline with the drive wheels.

Abstract: A control system limits reactive torque in a powertrain that is generated when braking force is applied to traction wheels during a sudden stop or other sudden braking event. The reactive torque generated at the traction wheels is prevented from being transmitted upstream through the driveline and powertrain by using a slip type clutch in the driveline to limit the upstream transfer of the reactive wheel torque. The clutch is directly actuated by the reactive torque and therefore does not require special controls or monitoring systems to sense the braking event. The clutch pressure may be automatically adjusted in response to certain operating conditions or events, thereby adjusting the point at which the clutch begins to slip due to reactive wheel torque.

Abstract: A system is provided for controlling the inertia of a vehicle's powertrain during sudden braking events. Torque generated by rapid deceleration of the vehicle's drive wheels during braking is prevented from being transmitted through the vehicle's driveline by a clutch which disengages the drive wheels from high effective inertia components in the driveline. The clutch is actuated by a signal produced by any of several sensors on the vehicle which sense a sudden braking event. Driveline speed is adjusted to match drive wheel speed before the clutch is deactivated to reengage driveline with the drive wheels.

Abstract: A system is provided for controlling automatic brake systems to avoid pulsing vehicle brakes at certain natural vibration frequencies of the vehicle's mechanical systems such as a powertrain and driveline. The natural vibration frequencies of the vehicle's systems are determined and correlated with a range of possible braking regimes implemented by an on-board automatic brake control, such as an anti-lock braking (ABS) system. A proposed, normally appropriate ABS braking response to a sudden braking condition is either modified, accelerated or delayed when the proposed response is deemed likely to excite a vehicle natural frequency. The system improves ABS operation in vehicles having high effective inertia powertrains, such as those used in hybrid electric vehicles.

Abstract: A process for preparing a compounds of the formula ##STR1## or a pharmaceutically acceptable acid addition salt thereof, which comprises reacting a piperazine salt of the formula ##STR2## with an alkyl halide containing compound of the formula ##STR3## in water with a reagent to neutralize the hydrohalic acid and heating the mixture under conditions which are suitable to effect the coupling of said piperazine salt with said alkyl halide containing compound.

Abstract: A process for preparing a compounds of the formula ##STR1## or a pharmaceutically acceptable acid addition salt thereof, which comprises reacting a monosubstituted piperazine of the formula ##STR2## with an alkyl halide containing compound of the formula ##STR3## in water with a reagent to neutralize the hydrohalic acid and refluxing the mixture under conditions which are suitable to effect the coupling of said monosubstituted piperazines with said alkyl halide containing compound.