Patents by Inventor Paul Brazeau

Paul Brazeau has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antiviral peptides and means for treating herpes infections
    Patent number: 5066783
    Abstract: Disclosed herein are antiviral peptides of the formula A-R.sup.8 -R.sup.9 -R.sup.10 -R.sup.11 -R.sup.12 -R.sup.13 -R.sup.14 -R.sup.15 B wherein A is from zero up to seven amino acid residues and includes a terminal hydrogen or a terminal N-acyl, or A is a phenylpropionyl with optional substitution of the para position of the phenyl, R.sup.8, R.sup.9, R.sup.10, R.sup.13, R.sup.14 and R.sup.15 are various amino acid residues with the stipulation that one or more of the three amino acid residues immediately preceeding R.sup.11 and R.sup.12 are independently Val, D-Val, Nva, D-Nva, Leu, D-Leu, Nle, D-Nle, Ile or D-Ile, and B is hydroxy, amino or lower alkylamino. The antiviral activity of the peptides can be enhanced by combining them with a protease inhibitor. The peptides and the combination are useful for the treatment of herpes viral infections in mammals.
    Type: Grant
    Filed: September 15, 1988
    Date of Patent: November 19, 1991
    Inventors: Eric A. Cohen, Pierrette Gaudreau, Jacques Michaud, Paul Brazeau, Yves Langelier
  • Antiviral pharmaceutical compositions and method of treating herpes
    Patent number: 5002932
    Abstract: Disclosed herein is a combination of bacitracin and acyclovir or equivalent derivatives thereof. The combination, as well as bacitracin itself, are useful for treating herpes viral infections.
    Type: Grant
    Filed: November 25, 1988
    Date of Patent: March 26, 1991
    Inventors: Yves Langelier, Pierrette Gaudreau, Paul Brazeau
  • Antiviral peptides and means for treating herpes infections
    Patent number: 4795740
    Abstract: Disclosed herein are antiviral peptides of the formula A-R.sup.8 -R.sup.9 -R.sup.10 -R.sup.11 -R.sup.12 -R.sup.13 -R.sup.14 -R.sup.15 -B wherein A is from zero up to seven amino acid residues and includes a terminal hydrogen or a terminal N-acyl, or A is a phenylacetyl with optional substitution of the para position of the phenyl, R.sup.8, R.sup.9, R.sup.10, R.sup.13, R.sup.14 and R.sup.15 are various amino acid residues with the stipulation that one or more of the four amino acid residues immediately preceding R.sup.11 may optionally be deleted, R.sup.11 and R.sup.12 are independently Val, D-Val, Nva, D-Nva, Leu, D-Leu, Nle, D-Nle, Ile or D-Ile, and B is hydroxy, amino or lower alkylamino. The antiviral activity of the peptides can be enhanced by combining them with a protease inhibitor. The peptides and the combination are useful for the treatment of herpes viral infections in mammals.
    Type: Grant
    Filed: May 7, 1987
    Date of Patent: January 3, 1989
    Inventors: Eric A. Cohen, Pierrette Gaudreau, Jacques Michaud, Paul Brazeau, Yves Langelier