Abstract: The disclosure provides, inter alia, opioid haptens, opioid hapten conjugates, opioid vaccines, methods of treating or preventing opioid use disorder, methods of treating opioid overdose, and methods of generating and/or isolating antibodies selective for opioids.

Abstract: A craniotomy pin is used to hold a flap of skull in place with respect to the surrounding skull after brain surgery. The pin is preferably an integral piece of biocompatible sterilizable material such as titanium or carbon fiber reinforced plastic. The head of the pin preferably comprises a first spherical segment having side reverse cut edges, and devoid of openings which can collect bacteria. The pin also includes a spherical segment locking portion, and a shaft connecting the head and locking portions. The shaft has a length less than the thickness of a human skull (e.g. about 3.5 mm or less). The locking portion preferably has sharp side edges and corners, and a sphere diameter and spherical extent less than that of the first spherical segment. The reverse cuts allow the head to be grasped with a tool and twisted when the shaft is in an elongated opening formed in the skull during brain surgery, so that the locking portion cuts into the skull and holds the skull flap to the surrounding skull.

Abstract: A halo vest (for cervical and spine injuries) having a body of structural material such as hard plastic has halo supporting rods and a halo attached to it. A lining of wicking material is provided for the vest body. The vest body has a surface configuration that avoids pressure on bony prominences, has flat surfaces at flat bone areas and curved surfaces at curved bone areas of the user, and exerts less than about seven pounds per square inch pressure on the wearer's skin. No dimension from an interior surface point to the closest peripheral portion is larger than the ability of the lining to readily wick liquid from the interior surface point to the peripheral portion so as to avoid skin wetness. The lining comprises a first layer of water proof and vapor proof material like cross-linked closed cell polyethylene foam having grooves to facilitate transport of liquid toward the periphery of the vest, and a second layer of soft, wicking textile material that is air, water, and vapor permeable.

Abstract: A shaped halo vest includes front and back vest components for overlying the front and back of the patient's upper torso. Each component is shaped three-dimensionally to load selected areas of the body, i.e., selected muscle groups, and avoid loading other selected areas of the body, i.e., bony prominences. The shaping includes three-dimensional compound curves for bowing the molded plastic vest components inwardly to transfer loads or outwardly to avoid transfer of loads. The marginal edges of the vest components are flared outwardly to avoid pinching or bruising the underlying tissue upon relative movement of the patient and vest. The three-dimensional compound curves and the flared edges contribute to the structural rigidity of the vest. The front and back components are secured one to the other by adjustable straps along the opposite sides of the lower portions of the vest and adjustable length shoulder straps. Vent holes are provided in the back vest component.