Patents by Inventor Paul Britton

Paul Britton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190223814
    Abstract: The present invention provides 18F-labeled amino acids or derivatives thereof having formula (I) and methods of making same, which can be suitable for PET imaging:
    Type: Application
    Filed: August 23, 2017
    Publication date: July 25, 2019
    Inventors: Paul SCHAFFER, Hua YANG, Robert BRITTON, Matthew NODWELL, Zheliang YUAN
  • Publication number: 20190022214
    Abstract: The present invention provides a live, attenuated coronavirus comprising a mutation in non-structural protein nsp-3 and/or deletion of accessory proteins 3a and 3b. The coronavirus may be used as a vaccine for treating and/or preventing a disease, such as infectious bronchitis, in a subject.
    Type: Application
    Filed: January 26, 2017
    Publication date: January 24, 2019
    Inventors: Erica Bickerton, Sarah Keep, Paul Britton
  • Patent number: 10130701
    Abstract: The present invention provides a live, attenuated coronavirus comprising a variant replicase gene encoding polyproteins comprising a mutation in one or more of non-structural protein(s) (nsp)-10, nsp-14, nsp-15 or nsp-16. The coronavirus may be used as a vaccine for treating and/or preventing a disease, such as infectious bronchitis, in a subject.
    Type: Grant
    Filed: July 23, 2015
    Date of Patent: November 20, 2018
    Assignee: THE PIRBRIGHT INSTITUTE
    Inventors: Erica Bickerton, Sarah Keep, Paul Britton
  • Patent number: 9969777
    Abstract: The present invention provides an infectious bronchitis virus (IBV) spike protein (S protein) which is based on an S protein from an IBV strain with restricted tissue tropism, but which comprises the sequence XBBXBX in the part of the S2 protein corresponding to residues 686 to 691 of the sequence given as SEQ ID No. 2, where B is a basic residue and X is any amino acid; and which comprises at least one of the following amino acid substitutions with reference to the position numbering of SEQ ID NO:2: Leucine (L) to Phenylalanine (F) at position 578 Asparagine (N) to Serine (S) at position 617 Asparagine (N) to Serine (S) at position 826 Leucine (L) to Phenylalanine (F) at position 857 and Isoleucine (I) to Valine (V) at position 1000 such that an IBV virus comprising the S protein has extended tissue tropism. The present invention also provides a virus comprising such an S protein.
    Type: Grant
    Filed: May 1, 2014
    Date of Patent: May 15, 2018
    Assignee: THE PIRBRIGHT INSTITUTE
    Inventors: Paul Britton, Erica Bickerton
  • Publication number: 20170216427
    Abstract: The present invention provides a live, attenuated coronavirus comprising a variant replicase gene encoding polyproteins comprising a mutation in one or more of non-structural protein(s) (nsp)-10, nsp-14, nsp-15 or nsp-16. The coronavirus may be used as a vaccine for treating and/or preventing a disease, such as infectious bronchitis, in a subject.
    Type: Application
    Filed: July 23, 2015
    Publication date: August 3, 2017
    Inventors: Erica Bickerton, Sarah Keep, Paul Britton
  • Publication number: 20160060303
    Abstract: The present invention provides an infectious bronchitis virus (IBV) spike protein (S protein) which is based on an S protein from an IBV strain with restricted tissue tropism, but which comprises the sequence XBBXBX in the part of the S2 protein corresponding to residues 686 to 691 of the sequence given as SEQ ID No. 2, where B is a basic residue and X is any amino acid; and which comprises at least one of the following amino acid substitutions with reference to the position numbering of SEQ ID NO:2: Leucine (L) to Phenylalanine (F) at position 578 Asparagine (N) to Serine (S) at position 617 Asparagine (N) to Serine (S) at position 826 Leucine (L) to Phenylalanine (F) at position 857 and Isoleucine (I) to Valine (V) at position 1000 such that an IBV virus comprising the S protein has extended tissue tropism. The present invention also provides a virus comprising such an S protein.
    Type: Application
    Filed: May 1, 2014
    Publication date: March 3, 2016
    Inventors: Paul Britton, Erica Bickerton
  • Patent number: 8828407
    Abstract: The present invention provides a chimaeric coronavirus S protein which is based on an S protein from a coronavirus strain with restricted tissue tropism, but which comprises at least part of the S2 subunit from a coronavirus strain with extended tissue tropism, such that a virus comprising the chimaeric S protein has extended tissue tropism. The present invention also provides a virus comprising such a chimaeric S protein.
    Type: Grant
    Filed: July 5, 2010
    Date of Patent: September 9, 2014
    Assignee: The Pirbright Institute
    Inventors: Paul Britton, Erica Bickerton, Maria Armesto
  • Publication number: 20120177675
    Abstract: The present invention provides a chimaeric coronavirus S protein which is based on an S protein from a coronavirus strain with restricted tissue tropism, but which comprises at least part of the S2 subunit from a coronavirus strain with extended tissue tropism, such that a virus comprising the chimaeric S protein has extended tissue tropism. The present invention also provides a virus comprising such a chimaeric S protein.
    Type: Application
    Filed: July 5, 2010
    Publication date: July 12, 2012
    Applicant: INSTITUTE FOR ANIMAL HEALTH
    Inventors: Paul Britton, Erica Bickerton, Maria Armesto
  • Patent number: 7445785
    Abstract: The present invention provides a vaccine for use in the protection of poultry against infectious bronchitis comprising an attenuated infectious bronchitis virus (IBV) and a pharmaceutical acceptable carrier or diluent, characterized in that the attenuated IBV comprises a heterologous spike gene. Such a vaccine is based on IBV strain Beaudette that is able to express a spike gone derived from a different IBV strain. The vaccines provided by the present invention also allow the administration via the in ovo route.
    Type: Grant
    Filed: March 3, 2004
    Date of Patent: November 4, 2008
    Assignees: Intervet International B.V., Institute for Animal Health
    Inventors: David Cavanagh, Paul Britton, Ian Tarpey
  • Publication number: 20070154489
    Abstract: The present invention provides a vaccine for use in the protection of poultry against infectious bronchitis comprising an attenuated infectious bronchitis virus (IBV) and a pharmaceutical acceptable carrier or diluent, characterized in that the attenuated IBV comprises a heterologous spike gene. Such a vaccine is based on IBV strain Beaudette that is able to express a spike gone derived from a different IBV strain. The vaccines provided by the present invention also allow the administration via the in ovo route.
    Type: Application
    Filed: March 3, 2004
    Publication date: July 5, 2007
    Inventors: David Cavanagh, Paul Britton, Ian Tarpey
  • Patent number: 6510780
    Abstract: A reversibly actuatable fluid hydraulic pump is described for use in a hydraulically driven elevator. The pump comprises a cylinder and a piston linearly actuatable within the cylinder by a ball screw race disposed over a spindle and connected to the piston. The shaft of the piston is hollow to receive the spindle as the piston is drawn along by virtue of the motion of the race along the spindle, and seals are provided at the free end of the piston which sealingly engage against the walls of the cylinder, and on the cylinder which sealingly engage with the shaft of the piston. A further feature of the invention is the provision of a compressible gas between the end of the cylinder and the end of the piston so that the expansion thereof reduces the work required to move the piston out of the cylinder, whereas when the system is relaxing, the compressible gas provides extra resistance and thus a smoother motion.
    Type: Grant
    Filed: August 3, 2001
    Date of Patent: January 28, 2003
    Assignee: Lomaxmain Limited
    Inventors: Bruce Eden, David Mantle, David Williams, Paul Britton