Patents by Inventor Paul Bruzinski

Paul Bruzinski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the synthesis of IB-MECA
    Patent number: 9102698
    Abstract: The present disclosure provides a method for the synthesis of IB-MECA. More specifically, the present disclosure provides a simple and high yield method for Good Manufacturing Production (GMP) of IB-MECA. The method involves the reaction of 6-halopurine-9-riboside with a diol protecting reagent; oxidation of the primary alcohol in the diol protected 6-halopurine-9-riboside with a diol protecting reagent; oxidation of the primary alcohol in the diol protected 6-halopurine; reaction of the diol protected 6-halopurine with a nucleophile (e.g. methylamine); substitution of the halogen group with iodobenzylamine and removal of the diol protecting group.
    Type: Grant
    Filed: March 13, 2008
    Date of Patent: August 11, 2015
    Assignee: CAN-FITE BIOPHARMA LTD.
    Inventors: Paul Bruzinski, Xuejun Liu, Cameron Gibb, Pedro E. HErnandez-Abad
  • PROCESS FOR THE SYNTHESIS OF IB-MECA
    Publication number: 20100087636
    Abstract: The present disclosure provides a method for the synthesis of IB-MECA. More specifically, the present disclosure provides a simple and high yield method for Good Manufacturing Production (GMP) of IB-MECA. The method involves the reaction of 6-halopurine-9-riboside with a diol protecting reagent; oxidation of the primary alcohol in the diol protected 6-halopurine-9-riboside with a diol protecting reagent; oxidation of the primary alcohol in the diol protected 6-halopurine; reaction of the diol protected 6-halopurine with a nucleophile (e.g. methylamine); substitution of the halogen group with iodobenzylamine and removal of the diol protecting group.
    Type: Application
    Filed: March 13, 2008
    Publication date: April 8, 2010
    Inventors: Paul Bruzinski, Xuejun Liu, Cameron Gibb, Pedro E. Hernandez-Abad