Abstract: The present disclosure provides compositions and methods for the treatment of ocular diseases associated with angiogenesis, particularly wet age-related macular degeneration.

Abstract: Embodiments herein relate to a local assistant system responding to voice input using an ear-wearable device. The system detects a wake-up signal and receives a first voice input communicating a first query content. The system includes speech recognition circuitry to determine the first query content, speech generation circuitry, and an input database of locally-handled user inputs. If the first audio input matches one of the locally-handled user inputs, then the system takes a local responsive action. If the first audio input does not match one of the locally-handled user inputs, then the system transmits at least a portion of the first query content over a wireless network to a network resource.

Abstract: Aspects of the subject disclosure may include, for example, obtaining first data pertaining to an outage in a first portion of a communications system, obtaining second data pertaining to a relationship between the first portion of the communications system and a second portion of the communications system, analyzing the first data the second data to identify a risk to communication services facilitated by the second portion of the communications system, determining that the risk is greater than a threshold, and generating, based on the determining, a recommendation for reducing the risk. Other embodiments are disclosed.

Abstract: The systems and methods described herein provide a wearable sweat sensing device. The device includes a sweat patch component including a sweat biochemical sensor patch having a substrate defining a hole, at least one biochemical sensor, and a capture wick including a tip that extends through the hole, the capture wick configured to channel sweat across the at least one biochemical sensor. The sweat patch component further includes a wick downstream from the capture wick and separated from the capture wick by a gap, and electronic circuitry disposed against at least one face of the wick, wherein an electronic response of the electronic circuitry changes as sweat flows through the wick. The wearable sweat sensing device further includes an electronics module component configured to facilitate assessing hydration of a wearer based on signals from the at least one biochemical sensor and the electronic circuitry.

Abstract: A fluid handling apparatus for a bioprocessing system includes a first plate having a first surface and a second surface, at least one fluid flow channel formed in the first surface, at least one valve recess formed in the first surface along the at least one fluid flow channel, and at least one fluid passageway extending through the first plate from the at least one fluid flow channel to the second surface, and a sealing layer disposed over the first surface and enclosing the at least one fluid flow channel. The at least one valve recess is configured to cooperate with an actuator and the sealing layer to prevent a flow of fluid through the at least one fluid flow channel.

Abstract: The present invention relates to a removal aid used to assist in the removal of clothing items such as jackets, sweaters, shirts and the like. The aid is a device having a clamp with two sections that are pivotally joined together. Each section has a head that is elongated. The clamp has a lock for locking the clamp in a closed position. A pull has two ends, one of which is connected to a clamp section. The second end of the pull can have a loop. The pull is preferably a flexible pull. A user secures the device onto an end of a sleeve and locks the clamp with the lock. Then, the user places the loop over upon an object so that the pull pulls the arm portion of the garment off from the user's arm as the user moves away or twists relative to the object.

Abstract: The present disclosure relates to a sample assessment device. By way of example, the sample assessment device may include a substrate including a sample application region; an amplification region comprising a plurality of amplification reagents; a waste region comprising an entrance fluidically coupled to the amplification region and extending away from the amplification region; and a detection region spaced apart from the amplification region. The sample assessment device may also include a valve coupled to the substrate and configured to separate the amplification region from the detection region in a closed configuration, wherein the amplification region and the valve are positioned on the sample assessment device between the sample application region and the detection region and wherein the sample assessment device is configured to permit lateral flow from the amplification region to the detection region when the valve is in an open configuration.

Abstract: A distributed feedback laser having a conjugated dendrimer as the active lasing component, and a method for patterning conjugated dendrimers.

Abstract: Compressed air and lattice structure cooling is disclosed. In an embodiment, an assembly includes a heat conductive lattice structure with open-cell voids. The assembly also includes a port configured to provide compressed air that is directed toward the heat conductive lattice structure. The assembly also includes a base configured to be coupled to an electronic component and thermally coupled to the heat conductive lattice structure.

Abstract: A fabric has first material yarns and second material yarns woven together to form a ground, The first material yarns are synthetic yarns, and the second material yarns are cotton pile yarns. A coloring process is performed which colors the second material yarns, but which does not take to the first material yarns. A second coloring or printing process is performed on the technical front.

Abstract: A fluid handling apparatus for a bioprocessing system includes a first plate having a first surface and a second surface, at least one fluid flow channel formed in the first surface, at least one valve recess formed in the first surface along the at least one fluid flow channel, and at least one fluid passageway extending through the first plate from the at least one fluid flow channel to the second surface, and a sealing layer disposed over the first surface and enclosing the at least one fluid flow channel. The at least one valve recess is configured to cooperate with an actuator and the sealing layer to prevent a flow of fluid through the at least one fluid flow channel.

Abstract: The systems and methods described herein provide a wearable sweat sensing device. The device includes a sweat patch component including a sweat biochemical sensor patch having a substrate defining a hole, at least one biochemical sensor, and a capture wick including a tip that extends through the hole, the capture wick configured to channel sweat across the at least one biochemical sensor. The sweat patch component further includes a wick downstream from the capture wick and separated from the capture wick by a gap, and electronic circuitry disposed against at least one face of the wick, wherein an electronic response of the electronic circuitry changes as sweat flows through the wick. The wearable sweat sensing device further includes an electronics module component configured to facilitate assessing hydration of a wearer based on signals from the at least one biochemical sensor and the electronic circuitry.

Abstract: A fabric has first material yarns and second material yarns woven together to form a ground, The first material yarns are synthetic yarns, and the second material yarns are cotton pile yarns. A coloring process is performed which colors the second material yarns, but which does not take to the first material yarns. A second coloring or printing process is performed on the technical front.

Abstract: A method is provided herein, the method includes: applying a sample comprising target nucleic acids to a sample application zone of a substrate; and flowing a nucleic acid amplification reaction mixture across a length of the substrate through the sample application zone to amplify the target nucleic acid forming a nucleic acid amplification product; wherein the target nucleic acid having a first molecular weight is substantially immobilized at the sample application zone and wherein the amplification product having a second molecular weight migrates away from the sample application zone. An associated device is also provided.

Abstract: A system, method, and computer program product are provided for automatically generating communication device metadata definitions. In use, device information is received from at least one instance of at least one communication device associated with a communication network. Additionally, a device metadata definition associated with the at least one communication device is automatically generated utilizing the device information, the device metadata definition representing at least attributes of the at least one communication device.

Abstract: Provided herein are methods and systems for rapid testing of films used in the manufacture of bioprocess bags. The methods described herein allow for determination of resistance to flexural fatigue while mimicking actual conditions in bioprocesses such as flexion and subsequent fatigue and failure of a bioprocess bag made of a film when it is placed on a rocking platform.

Abstract: The present disclosure relates to a sample assessment device. By way of example, the sample assessment device may include a substrate including a sample application region; an amplification region comprising a plurality of amplification reagents; a waste region comprising an entrance fluidically coupled to the amplification region and extending away from the amplification region; and a detection region spaced apart from the amplification region. The sample assessment device may also include a valve coupled to the substrate and configured to separate the amplification region from the detection region in a closed configuration, wherein the amplification region and the valve are positioned on the sample assessment device between the sample application region and the detection region and wherein the sample assessment device is configured to permit lateral flow from the amplification region to the detection region when the valve is in an open configuration.

Abstract: The present disclosure relates to a sample assessment device. By way of example, the sample assessment device may include a substrate including a sample application region; an amplification region comprising a plurality of amplification reagents; a waste region comprising an entrance fluidically coupled to the amplification region and extending away from the amplification region; and a detection region spaced apart from the amplification region. The sample assessment device may also include a valve coupled to the substrate and configured to separate the amplification region from the detection region in a closed configuration, wherein the amplification region and the valve are positioned on the sample assessment device between the sample application region and the detection region and wherein the sample assessment device is configured to permit lateral flow from the amplification region to the detection region when the valve is in an open configuration.

Abstract: A distributed feedback laser having a conjugated dendrimer as the active lasing component, and a method for patterning conjugated dendrimers.