Abstract: The present invention relates to an online method and system for estimating the manufacturing cost of a component. A preferred method embodiment of the present invention includes receiving a component model which includes quantitative driver(s) and cost algorithm(s) used to determine the estimated manufacturing cost, receiving values for each quantitative driver, determining the estimated manufacturing costs for the component based on the values for each quantitative driver and the cost algorithm(s), and transmitting the estimated manufacturing cost to a user. A preferred computer system of the present invention is configured to receive a component model which includes quantitative driver(s) and cost algorithm(s), receive values for each quantitative driver, determine the estimated manufacturing costs for the component based on the quantitative driver values and the cost algorithm(s), and transmit the estimated manufacturing cost to a user.

Abstract: A compound of formula (I) or a pharmaceutically-acceptable salt thereof, may be made by a process including a triflating step by which a ketone of formula (II) is converted into a triflate of formula (III) in the presence of a base comprising a tertiary or heterocyclic amine such that the pKa of the conjugate acid at 25° C. is within the range 5.21 to 12.

Abstract: Process for fabricating an array of polymers on a solid support is provided having the steps of coupling a monomer with a reactive side masked by a protecting group to a growing polymer chain, optionally capping the monomer or monomer chains that have not reacted in a given cycle, deprotecting the product with a deprotecting agent, repeating the above steps on regions of the support as necessary to give polymers having a desired sequence and length and oxidizing the inter monomer linkage post-synthetically.

Abstract: Improved nucleic acid arrays are provided which have been prepared using nucleoside phosphoramidites having reduced levels of interfering phosphoramidite impurities.

Abstract: The present invention relates to an online method and system for estimating the manufacturing cost of a component. A preferred method embodiment of the present invention includes receiving a component model which includes quantitative driver(s) and cost algorithm(s) used to determine the estimated manufacturing cost, receiving values for each quantitative driver, determining the estimated manufacturing costs for the component based on the values for each quantitative driver and the cost algorithm(s), and transmitting the estimated manufacturing cost to a user. A preferred computer system of the present invention is configured to receive a component model which includes quantitative driver(s) and cost algorithm(s), receive values for each quantitative driver, determine the estimated manufacturing costs for the component based on the quantitative driver values and the cost algorithm(s), and transmit the estimated manufacturing cost to a user.