Abstract: The invention relates to a breathing assistance apparatus that may be configured to reduce the risk of damage to electronics within the apparatus as a result of liquid leaks within the apparatus or impacts to the apparatus. In other forms, the apparatus may be configured to allow for easy assembly and/or safe operation.

Abstract: A catheter system includes a catheter, an introducer sheath, and a tubular plug. The catheter comprises an elongate body having an expandable medical device coupled with a distal end thereof. The introducer sheath comprises an elongate body defining a lumen therein. The introducer sheath is disposed over the catheter to form a gap therebetween. The tubular plug comprises an elongate body and extends through the lumen of the introducer sheath. The tubular plug is disposed between the catheter and the introducer sheath to occlude the gap. Further, the tubular plug is releasably fixed relative to the introducer sheath such that the tubular plug is removable from the lumen to allow the expandable medical device to pass therethrough.

Abstract: Described herein are novel PRMT5 inhibitors of Formula I and pharmaceutically acceptable salts thereof, as well as the pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity and may have use in treating proliferative, metabolic and blood disorders.

Abstract: Fiber optic terminals, tools and methods for adjusting a split ratio of a fiber optic terminal are disclosed. In one embodiment, a tool for adjusting a split ratio of a fiber optic terminal includes an axle for insertion into a port of the fiber optic terminal, and a terminal engagement body disposed about the axle. The terminal engagement body includes a terminal engagement feature for engaging an alignment feature within the fiber optic terminal, wherein the axle is free to rotate with respect to the terminal engagement body, and a set-point indicator. The tool further includes an end piece coupled to the axle, and a plurality of set-point markers, wherein rotation of the end piece causes rotation of the axle and an alignment between one set-point marker of the plurality of set-point markers with the set-point indicator indicates the split ratio of the fiber optic terminal.

Abstract: Described herein are compounds of Formula (I) and pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity and may have use in treating proliferative, such as cancer, metabolic and blood disorders. Compounds of Formula (I) have the following structure of Formula (I).

Abstract: A channel graphical user interface (GUI) of a content sharing platform is provided for presentation to a channel owner. A request is received, via the channel GUI, to enable an online community option that (i) facilitates an online conversation between the channel owner and a subset of viewers of the channel of the channel owner on the content sharing platform, and (ii) allows the channel owner to control viewer responses that are permitted during the online conversation. In response to the request of the channel owner to enable the online community option, the online community option is associated with the channel in a data store, and the channel GUI is modified, the modified channel GUI presenting an online community GUI element representing the online community option.

Abstract: Described herein are novel PRMT5 inhibitors of Formula I and pharmaceutically acceptable salts thereof, as well as the pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity and may have use in treating proliferative, metabolic and blood disorders.

Abstract: A lithographic apparatus having a substrate table, a projection system, an encoder system, a measurement frame and a measurement system. The substrate table has a holding surface for holding a substrate. The projection system is for projecting an image on the substrate. The encoder system is for providing a signal representative of a position of the substrate table. The measurement system is for measuring a property of the lithographic apparatus. The holding surface is along a plane. The projection system is at a first side of the plane. The measurement frame is arranged to support at least part of the encoder system and at least part of the measurement system at a second side of the plane different from the first side.

Abstract: Video submission survey reviewer device, system, process, and computer program product capable of recording campaign or survey content including video, analyzing the recorded content, and synthesizing information about the recorded content to provide improved and more efficient analysis or curation and presentation of the processed data and its associated information.

Abstract: At least one example embodiment discloses a section of an electronic-vaping device including a pressure sensor configured to measure a current ambient pressure, the pressure sensor further configured to output the current ambient pressure measurement in accordance with a read request frequency, and a controller configured to determine a mode of operation of the electronic-vaping device, control the read request frequency based on the determined mode of operation, and detect a threshold pressure change based on the current ambient pressure and a baseline pressure.

Abstract: At least one example embodiment discloses a section of an electronic-vaping device including a pressure sensor configured to measure a current ambient pressure, the pressure sensor further configured to output the current ambient pressure measurement in accordance with a read request frequency, and a controller configured to determine a mode of operation of the electronic-vaping device, control the read request frequency based on the determined mode of operation, and detect a threshold pressure change based on the current ambient pressure and a baseline pressure.

Abstract: A battery section of an electronic vaping device may include a housing extending in a longitudinal direction, the housing having a first end and a second end, a power supply in the housing, a control circuit in the housing, and a conductive contact assembly at the second end of the housing, the contact assembly electrically connecting the power supply and the control circuit. The contact assembly is configured to receive external power and at least one command.

Abstract: Methods, systems, and apparatus, including a media player and computer-readable mediums, are described for rendering media content at a frame rate that is safe to a user. A system, or its media player, obtains media content that includes video content having multiple frames. The system determines a frame rate representing a rate for sequentially displaying the frames to the user when the media player plays the media content. Image content of each frame is scanned and data describing different photosensitivity thresholds is obtained. Based on a photosensitivity of the user, the system determines that one or more frames in a portion of the media content include image content that is unsafe to the user when the media player plays the media content. The system selectively decreases a frame playback rate for the portion of the media content as a function of an input value that is selectable by the user.

Abstract: A battery section of an electronic vaping device may include a housing extending in a longitudinal direction, the housing having a first end and a second end, a power supply in the housing, a control circuit in the housing, and a conductive contact assembly at the second end of the housing, the contact assembly electrically connecting the power supply and the control circuit. The contact assembly is configured to receive external power and at least one command.

Abstract: A method of making a cutting element for use on an earth-boring tool may include forming the cutting element including a cutting table formed from a superabrasive polycrystalline material. The method may further include polishing a cutting surface of the cutting table by pulsing a laser onto the cutting surface of the cutting table. The cutting element may include a superabrasive polycrystalline cutting table including a cutting surface substantially free of micro-anomalies in the superabrasive material.

Abstract: At least one example embodiment discloses a section of an electronic-vaping device including a pressure sensor configured to measure a current ambient pressure, the pressure sensor further configured to output the current ambient pressure measurement in accordance with a read request frequency, and a controller configured to determine a mode of operation of the electronic-vaping device, control the read request frequency based on the determined mode of operation, and detect a threshold pressure change based on the current ambient pressure and a baseline pressure.

Abstract: Methods and systems are described that use artificial intelligence (AI)-based natural language processing (NLP) techniques to rapidly analyze, merge, and/or identify relationships between systems engineering artifacts (e.g., system requirements, system architecture descriptions, research requirements, risk assessments, etc.) to accelerate systems engineering program management, technical capability development, and acquisition initiatives associated with systems engineering projects.

Abstract: At least one example embodiment discloses a section of an electronic-vaping device including a pressure sensor configured to measure a current ambient pressure, the pressure sensor further configured to output the current ambient pressure measurement in accordance with a read request frequency, and a controller configured to determine a mode of operation of the electronic-vaping device, control the read request frequency based on the determined mode of operation, and detect a threshold pressure change based on the current ambient pressure and a baseline pressure.

Abstract: A solid-state battery and a method of making the same are disclosed. The battery includes a base frame or support, first and second exterior contacts on the base frame/support, stacked solid-state battery unit cells, first and second electrical connections, and encapsulation in contact with the base frame/support and covering the solid-state battery unit cells and the electrical connections. Each stacked solid-state battery unit cell is on a metal substrate and has exposed cathode and anode current collectors. The electrical connections respectively electrically connect the exposed cathode and anode current collectors to the first and second exterior contacts. The method includes forming the stacked solid-state battery unit cells on the base frame/support, forming the exterior contacts on the base frame/support, electrically connecting the exposed cathode and anode current collectors to the respective exterior contacts, and encapsulating the solid-state battery unit cells and the electrical connections.

Abstract: An absorption chiller includes a boiler with a vessel for storing a working fluid and a heat source configured to heat the working fluid. A first device is configured to cool the working fluid, and a second device is configured to cool the working fluid. A flow path is arranged to enable the working fluid to flow from the boiler through the first device, through the second device and back to the boiler. A first waste heat source is generated by the first device when cooling the working fluid. The first waste heat source is configured to heat the working fluid along the flow path after exiting the second device and prior to re-entering the boiler.