Patents by Inventor Paul C. Bossle

Paul C. Bossle has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • High performance liquid chromatography (HPLC) analysis of sulfur mustards and their decomposition by-products by derivatization
    Patent number: 4565787
    Abstract: A method for the simultaneous detection, separation and analysis by reverse hase HPLC of sulfur mustard type compounds and their major hydrolysis and oxidation by-products utilizes a novel precolumn enhancement derivatization procedure. The method involves the reaction of these nonchromophoric sulfides with N-halogeno-N-metal arylsulfonamidates on a microscale to produce UV or visible absorbing or fluorescing arylsulfonylsulfilimine compounds. These arylsulfonylsulfilimine derivatives can then be readily separated on a low polarity C-18 column by reverse phase HPLC. The method permits quantitation of these sulfides by UV detector response in quantities as small as 20 nanograms.
    Type: Grant
    Filed: May 9, 1983
    Date of Patent: January 21, 1986
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Paul C. Bossle, John J. Martin, Emory W. Sarver, Harold Z. Sommer