Abstract: A method for switching railcars at a railroad yard includes accessing a list of selected railcars for an outgoing train. The method further includes generating a plurality of train consists that each comply with a set of train rules. The method further includes displaying indications of the generated train consists and their associated number of railyard switch moves on an electronic display. The method further includes receiving a user selection of a desired train consist from the plurality of displayed train consists. The method further includes generating a plurality of switch lists according to the desired train consist and a current inventory of railcars in the railyard. The switch lists include instructions about how to form the desired train consist in the railyard. The method further includes displaying the plurality of switch lists on the electronic display.

Abstract: Methods and systems for patient-specific post-surgery mortality prediction are disclosed. The methods and systems include: receiving a plurality of pre-operative factor indications for a patient; obtaining a first trained machine learning model and an interpretable model; applying the plurality of pre-operative factor indications to the first trained machine learning model to obtain a plurality of confidence values corresponding to the plurality of pre-operative factor indications; applying the plurality of confidence values to the interpretable model to obtain a plurality of interpretation indications, the plurality of interpretation indications corresponding to a subset of the plurality of pre-operative factor indications, the plurality of interpretation indications most contributing to mortality of the patient, the plurality of interpretation indications being specific to the patient; and outputting a survival probability of the patient based on the plurality of interpretation indications.

Abstract: The present invention polynucleotide aptamers that selectively bind to and inhibit the function of osteopontin, pharmaceutical compositions comprising the same, and methods of use for diagnostics and treatment of diseases and disorders associated with osteopontin.