Patents by Inventor Paul C. Lobben

Paul C. Lobben has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of N,N-dicyclopropyl-4-(1,5-dimethyl-1H-pyrazol-3-ylamino)-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide
    Patent number: 9518058
    Abstract: The invention relates to an improved process for synthesizing N,N-dicyclopropyl-4-(1,5-dimethyl-1H-pyrazol-3-ylamino)-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide of the formula: (I) Compound (I) is currently in clinical trials for the treatment of myeloproliferative disorders, such as polycythaemia vera, thrombocythaemia and primary myelofibrosis.
    Type: Grant
    Filed: August 28, 2014
    Date of Patent: December 13, 2016
    Assignee: Bristol-Myers Squibb Company
    Inventors: Martin D. Eastgate, Gregory L. Beutner, Benjamin Cohen, Nicolas Cuniere, Lopa V. Desai, Monica Fitzgerald, Qi Gao, Michael Bryan Hay, Michael Joseph Lawler, Paul C. Lobben, Christopher S. Regens, Thorsten Rosner, Neil Strotman, Carolyn S. Wei, Yi Xiao, Bin Zheng, Keming Zhu
  • PROCESS FOR THE PREPARATION OF N,N-DICYCLOPROPYL-4-(1,5-DIMETHYL-1H-PYRAZOL-3-YLAMINO)-6-ETHYL-1-METHYL-1,6-DIHYDROIMIDAZO[4,5-d]PYRROLO[2,3-b]PYRIDINE-7-CARBOXAMIDE
    Publication number: 20160229854
    Abstract: The invention relates to an improved process for synthesizing N,N-dicyclopropyl-4-(1,5-dimethyl-1H-pyrazol-3-ylamino)-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide of the formula: (I) Compound (I) is currently in clinical trials for the treatment of myeloproliferative disorders, such as polycythaemia vera, thrombocythaemia and primary myelofibrosis.
    Type: Application
    Filed: August 28, 2014
    Publication date: August 11, 2016
    Inventors: Martin D. Eastgate, Gregory L. Beutner, Benjamin Cohen, Nicolas Cuniere, Lopa V. Desai, Monica Fitzgerald, Qi Gao, Michael Bryan Hay, Michael Joseph Lawler, Paul C. Lobben, Christopher S. Regens, Thorsten Rosner, Neil Strotman, Carolyn S. Wei, Yi Xiao, Bin Zheng, Keming Zhu
  • PROCESSES FOR PREPARING TETRAHYDROISOQUINOLINES
    Publication number: 20160022675
    Abstract: Disclosed are processes for preparing tetrahydroisoquinolines, intermediates useful in the preparation of tetrahydroisoquinolines, processes for preparing such intermediates, and compositions comprising the tetrahydroisoquinolines and other compounds, e.g, intermediates and by-products of the processes described herein. Pharmaceutical compositions comprising tetrahydroisoquinolines, methods of using tetrahydroisoquinolines in the treatment of depression are also disclosed.
    Type: Application
    Filed: March 12, 2014
    Publication date: January 28, 2016
    Inventors: Francisco GONZALEZ-BOBES, David Alan CONLON, Paul C. LOBBEN, Justin Lockheart BURT, Joshua ENGSTROM, Carolyn S. WEI, Jason J. ZHU, Yu FAN
  • Process for the preparation of [(1R), 2S]-2-aminopropionic acid 2-[4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2, 1-F][1,2,4]triazin-6-yloxy]-1-methylethyl ester
    Patent number: 7671199
    Abstract: The invention relates to an improved process for preparing [(1R), 2S]-2-aminopropionic acid 2-[4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy]-1-methylethyl ester of the formula: Compound I has been shown to be useful for the treatment of certain types of cancer.
    Type: Grant
    Filed: April 20, 2007
    Date of Patent: March 2, 2010
    Assignee: Britsol-Myers Squibb Company
    Inventors: Gerard A. Crispino, Mourad Hamedi, Thomas L. LaPorte, John E. Thornton, Jaan A. Pesti, Zhongmin Xu, Paul C. Lobben, David K. Leahy, Jale Muslehiddinoglu, Chiajen Lai, Lori Ann Spangler, Robert P. Discordia, Francis S. Gibson
  • Methods for the preparation of pyrrolotriazine compounds
    Patent number: 7504521
    Abstract: A method for preparing a compound having the formula: including the steps of: (a) cyclizing a compound of formula II: to form a compound of formula I: (b) deprotecting the nitrogen atom of the compound of formula I by amination or hydrogenation to form compound III.
    Type: Grant
    Filed: August 5, 2005
    Date of Patent: March 17, 2009
    Assignee: Bristol-Myers Squibb Co.
    Inventor: Paul C. Lobben