Patents by Inventor Paul C. Tumeh

Paul C. Tumeh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for stratifying non-responders to therapies that block PD1/PDL1 axis
    Patent number: 11275080
    Abstract: A method of analyzing a biological sample from a subject that has a tumor or cancer, comprising: determining, for target cells having a phenotype of interest spatial resolution of the target cells, density of the spatially resolved target cells in the sample; and proximity between spatially resolved target cells of interest in the sample; and determining an overall score based at least in part on the preceding parameters. A method for identifying a patient as a responder to single agent anti-PD-1 or anti-PD-L1 therapy is provided. Similar methods are provided for detecting adaptive immune resistance, the presence of cancer in a patient sample, determining efficacy of cancer therapy, and determining response to and monitoring the efficacy of cancer therapy.
    Type: Grant
    Filed: November 5, 2015
    Date of Patent: March 15, 2022
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Paul C. Tumeh, Antoni Ribas
  • COMPOSITIONS AND METHODS FOR CANCER IMMUNOTHERAPY
    Publication number: 20200385478
    Abstract: Provided herein are analytical methods to be applied to samples, diagnostic methods, methods of determining a therapeutic regimens, and methods of treating cancer in a subject comprising compositions described herein.
    Type: Application
    Filed: January 4, 2019
    Publication date: December 10, 2020
    Inventor: Paul C. Tumeh
  • COMPOSITIONS AND TREATMENT METHODS FOR CANCER IMMUNOTHERAPY
    Publication number: 20190135923
    Abstract: Provided herein are analytical methods to be applied to samples, diagnostic methods, methods of determining a therapeutic regimens, and methods of treating cancer in a subject comprising compositions described herein.
    Type: Application
    Filed: January 8, 2019
    Publication date: May 9, 2019
    Inventors: Paul C. TUMEH, Peter THOMPSON
  • METHODS FOR STRATIFYING NON-RESPONDERS TO THERAPIES THAT BLOCK PD1/PDL1 AXIS
    Publication number: 20160123964
    Abstract: A method of analyzing a biological sample from a subject that has a tumor or cancer, comprising: determining, for target cells having a phenotype of interest spatial resolution of the target cells, density of the spatially resolved target cells in the sample; and proximity between spatially resolved target cells of interest in the sample; and determining an overall score based at least in part on the preceding parameters. A method for identifying a patient as a responder to single agent anti-PD-1 or anti-PD-L1 therapy is provided. Similar methods are provided for detecting adaptive immune resistance, the presence of cancer in a patient sample, determining efficacy of cancer therapy, and determining response to and monitoring the efficacy of cancer therapy.
    Type: Application
    Filed: November 5, 2015
    Publication date: May 5, 2016
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Paul C. TUMEH, Antoni RIBAS
  • Compositions And Methods For Treating Or Preventing Immuno-Inflammatory Disease
    Publication number: 20130202712
    Abstract: The present invention relates to compositions and methods for the treatment of immuno-inflammatory conditions comprising the administration of a polyphenolic phytoalexin compartmentalized in a biocompatible and/or biodegradable polymeric carrier, and to the use of biocompatible and/or biodegradable polymeric carriers comprising resveratrol and block copolymers and these compositions with an additional compartmentalized pharmaceutically active agent.
    Type: Application
    Filed: March 2, 2011
    Publication date: August 8, 2013
    Applicant: VINDICO NANOBIO TECHNOLOGY, INC.
    Inventors: Eric M. Ostertag, Paul C. Tumeh, P. Peter Ghoroghchian