Patents by Inventor Paul C. Watts

Paul C. Watts has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds for treating gastroduodenal diseases
    Patent number: 6372781
    Abstract: Spirolaxine, the compound of formula (I) wherein R is H, and the novel compounds of formula (I) wherein R is (C1-C5) alkyl or CH3(CH2)nCO and n is 1, 2, 3 or 4 are useful in treating gastroduodenal diseases such as gastric ulcers, duodenal ulcers and gastric cancer caused by Helicobacter pylori. Spirolaxine and spirolaxine methyl ether are isolated from the fermentation of Sporotrichum pruinosum ATCC 74278. Spirolaxine and the compounds of formula (I) are also useful in combination with H2 antagonist, colloidal bismuth subcitrate and other antibiotics.
    Type: Grant
    Filed: June 7, 2000
    Date of Patent: April 16, 2002
    Assignee: Pfizer Inc.
    Inventors: Mark A. Guadliana, Liang H. Huang, Takushi Kaneko, Paul C. Watts
  • Spirolaxine derivatives for treating gastrobuodenal diseases
    Patent number: 6174710
    Abstract: Spirolaxine, the compound of formula (I) wherein R is H, and the novel compounds of formula (I) wherein R is (C1-C6)alkyl or CH3(CH2)nCO and n is 1, 2, 3 or 4 are useful in treating gastroduodenal diseases such as gastric ulcers, duodenal ulcers and gastric cancer caused by Helicobacter pylori. Spirolaxine and spirolaxine methyl ether are isolated from the fermentation of Sporotrichum pruinosum ATCC 74278. Spirolaxine and the compounds of formula (I) are also useful in combination with H2 antagonist colloidal bismuth subcitrate and other antibiotics.
    Type: Grant
    Filed: January 16, 1997
    Date of Patent: January 16, 2001
    Assignee: Pfizer Inc.
    Inventors: Mark A. Guadliana, Liang H. Huang, Takushi Kaneko, Paul C. Watts
  • Erythromycin D and esters thereof by fermentation with Nocardia sp. ATCC 39043
    Patent number: 4582796
    Abstract: Fermentation of a culture of Nocardia sp. ATCC 39043 produces an antibiotic complex comprising erythromycin D, 3",4"-di-O-acetylerythromycin D, 3"-O-acetyl-4"-O-propionylerythromycin D and 4"-O-acetylerythromycin D. The components are separated and are each useful in vitro and in vivo as antibacterial agents. If erythromycin D is the desired product, the esters can be hydrolyzed prior to the separation of the erythromycin D.
    Type: Grant
    Filed: April 16, 1984
    Date of Patent: April 15, 1986
    Assignee: Pfizer, Inc.
    Inventors: Walter D. Celmer, Walter P. Cullen, Paul C. Watts, Riichiro Shibakawa, Junsuke Tone
  • Erythromycin D and esters thereof
    Patent number: 4496546
    Abstract: Fermentation of a culture of Nocardia sp. ATCC 39043 produces an antibiotic complex comprising erythromycin D, 3",4"-di-O-acetylerythromcyin D, 3"-O-acetyl-4"-O-propionylerythromycin D and 4"-O-acetylerythromycin D. The components are separated and are each useful in vitro and in vivo as antibacterial agents. If erythromycin D is the desired product, the esters can be hydrolyzed prior to the separation of the erythromycin D.
    Type: Grant
    Filed: April 12, 1982
    Date of Patent: January 29, 1985
    Assignee: Pfizer Inc.
    Inventors: Walter D. Celmer, Walter P. Cullen, Paul C. Watts, Riichiro Shibakawa, Junsuke Tone
  • Antibiotics produced by species of Nocardia
    Patent number: 4224314
    Abstract: A species of Nocardia, designated Nocardia argentinensis Huang ATCC 31438, when subjected to aerobic submerged fermentation, produces an antibiotic complex containing as its major component antibiotic Compound 51,467. Methods for the recovery and purification of antibiotic Compound 51,467 and minor antibiotic components, Compounds 52,726 and 52,748, and some of their properties are outlined.
    Type: Grant
    Filed: March 2, 1979
    Date of Patent: September 23, 1980
    Assignee: Pfizer Inc.
    Inventors: Walter D. Celmer, Paul C. Watts, Walter P. Cullen, Liang H. Huang, Riichiro Shibakawa, Junsuke Tone
  • Polypeptide antibiotic produced by a new subspecies of streptosporangium
    Patent number: 4083963
    Abstract: A new sulfur-containing polypeptide antibiotic produced by two strains of Streptosporangium under submerged fermentation conditions is useful for the treatment of microbial infections and in improving feed utilization efficiency in ruminants.
    Type: Grant
    Filed: June 1, 1977
    Date of Patent: April 11, 1978
    Assignee: Pfizer Inc.
    Inventors: Walter D. Celmer, Walter P. Cullen, Charles E. Moppett, John B. Routien, Paul C. Watts, Riichiro Shibakawa, Junsuke Tone