Abstract: The present invention provides EBNA1 inhibitors, and/or pharmaceutical compositions comprising the same, that are useful for the treatment of diseases caused by EBNA1 activity, such as, but not limited to, cancer, infectious mononucleosis, chronic fatigue syndrome, multiple sclerosis, systemic lupus erythematosus and/or rheumatoid arthritis. The present invention further provides EBNA1 inhibitors, and/or pharmaceutical compositions comprising the same, that are useful for the treatment of diseases caused by latent Epstein-Barr Virus (EBV) infection and/or lytic EBV infection.

Abstract: Stress reducing system and associated method for reducing stresses at a desired position in an offshore production or drilling system, the offshore production or drilling system comprising: a seabed structure, a floating structure and a riser (24) extending there between, the riser being tensioned, the riser (24) comprising at least a first part (45) and a second part (46), which second part (46) is connected to the first part (45) via a flexible connection (20) allowing an axial, angular and/or rotational movement between the first and second parts (45, 46), said stress reducing system comprises:—a first sensor (41) for real-time monitoring of stresses at the desired position, positioned at or close to the desired position (20),—an actuating system (42) arranged at the flexible connection (20, the actuating system (42) being connected to said first and second parts (45, 46), and wherein the actuating system (45, 46) is configured to apply a force to the first or second part (45, 46) when the first and second

Abstract: A modular accelerated cure system, for which the modules are of a size and weight to each be easily portable by one person, may be configured to fit a variety of parts, e.g., carbon fiber reinforced plastic (CFRP) components, such as found in the manufacture of composite aerospace structures. The system may be used to accelerate the cure of materials that allow elevated temperature cures, e.g., sealants, primers, coatings, paints, adhesives, and protective coatings, by increasing the ambient temperature surrounding a part, or a portion of the part, within each module in a controlled manner. The system is modular in that a number of modules may be fitted together to operate in unison and also may be adapted to fit parts of a variety of contours, shapes, and sizes. Temperature within each module may be controlled using a heat controller that receives a temperature indication from each module.

Abstract: Stress reducing system and associated method for reducing stresses at a desired position in an offshore production or drilling system, the offshore production or drilling system comprising: a seabed structure, a floating structure and a riser (24) extending there between, the riser being tensioned, the riser (24) comprising at least a first part (45) and a second part (46), which second part (46) is connected to the first part (45) via a flexible connection (20) allowing an axial, angular and/or rotational movement between the first and second parts (45, 46), said stress reducing system comprises:—a first sensor (41) for real-time monitoring of stresses at the desired position, positioned at or close to the desired position (20),—an actuating system (42) arranged at the flexible connection (20, the actuating system (42) being connected to said first and second parts (45, 46), and wherein the actuating system (45, 46) is configured to apply a force to the first or second part (45, 46) when the first and second

Abstract: A modular accelerated cure system, for which the modules are of a size and weight to each be easily portable by one person, may be configured to fit a variety of parts, e.g., carbon fiber reinforced plastic (CFRP) components, such as found in the manufacture of composite aerospace structures. The system may be used to accelerate the cure of materials that allow elevated temperature cures, e.g., sealants, primers, coatings, paints, adhesives, and protective coatings, by increasing the ambient temperature surrounding a part, or a portion of the part, within each module in a controlled manner. The system is modular in that a number of modules may be fitted together to operate in unison and also may be adapted to fit parts of a variety of contours, shapes, and sizes. Temperature within each module may be controlled using a heat controller that receives a temperature indication from each module.

Abstract: A bicycle trainer includes a roller support assembly and a roller positioned about the roller support assembly wherein the roller includes an aperture. A fixing member is disposed in the aperture to secure the roller to the roller support assembly allowing rotation of the roller. An element capable of being sensed disposed in the aperture and a sensor is positioned within the trainer at a stationary location wherein the sensor is configured to sense the element and provide a signal indicative of rotation of the roller.

Abstract: The present invention relates to a riser joint for a riser with a joint connecting two parts of a riser where the two parts are allowed angular displacement. According to the invention the riser joint comprises means for connection to the two parts of the riser at a distance from the joint, and means for adding a force between the two parts. The invention also relates to a method for reducing bending moments in a riser at a connection between the riser and a subsea installation.

Abstract: A bicycle trainer includes a roller support assembly and a roller positioned about the roller support assembly wherein the roller includes an aperture. A fixing member is disposed in the aperture to secure the roller to the roller support assembly allowing rotation of the roller. An element capable of being sensed disposed in the aperture and a sensor is positioned within the trainer at a stationary location wherein the sensor is configured to sense the element and provide a signal indicative of rotation of the roller.

Abstract: The invention relates a cylinder release arrangement, wherein at least one cylinder is arranged with a piston within the cylinder, and a cylinder head closing off one end of the cylinder, forming a chamber between the piston and the cylinder head, wherein the cylinder is provided to arrange a leakage of fluid from one side of a piston to the other side of the piston, when the piston is in a given position within the cylinder, and release means are provided for the subsequently controlled release of the cylinder head from the cylinder. The invention also comprises a cylinder arrangement with a release mechanism.

Abstract: The invention relates to a safety joint and a method of operation, the safety joint comprising: a first riser part and a second riser part overlapping in an axial direction and having end connections to be connectable as part of a riser, a release unit, locking the two riser parts together in a not activated mode, the release unit having other modes comprising a partly activated mode and fully activated mode, where the release unit comprises at least one axial extending tension rod connected between the two riser parts, which tension rod is configured to deform plastically before breaking, thereby activating the partly and fully activated modes.

Abstract: The invention relates to a safety joint and a method of operation, the safety joint comprising: a first riser part and a second riser part overlapping in an axial direction and having end connections to be connectable as part of a riser, a release unit, locking the two riser parts together in a not activated mode, the release unit having other modes comprising a partly activated mode and fully activated mode, where the release unit comprises at least one axial extending tension rod connected between the two riser parts, which tension rod is configured to deform plastically before breaking, thereby activating the partly and fully activated modes.

Abstract: The invention relates a cylinder release arrangement, wherein at least one cylinder is arranged with a piston within the cylinder, and a cylinder head closing off one end of the cylinder, forming a chamber between the piston and the cylinder head, wherein the cylinder is provided to arrange a leakage of fluid from one side of a piston to the other side of the piston, when the piston is in a given position within the cylinder, and release means are provided for the subsequently controlled release of the cylinder head from the cylinder. The invention also comprises a cylinder arrangement with a release mechanism.

Abstract: The present invention regards a joint for use in a riser (1) extending between a floating installation (3) and a subsea installation (2). The joint comprises an inner pipe segment (21) and an outer pipe segments (22), arranged moveable relative each other in an axial direction and connectable to respective riser segments, forming a chamber (23) between them with a radially extending piston (24), dividing the chamber (23) in a first chamber part (25) and a second chamber part (26), wherein on of said chamber parts (25) in an initial position of the joint is adapted to contain a mainly incompressible fluid, this chamber part (25) decreasing in volume as the inner pipe segment (21) is moved relatively out of the outer pipe segment (22).

Abstract: A method for manufacturing a composite cable comprises providing a number of electrical conductors which are each covered by insulation, providing a number of fibres for strength, coating the fibres with a liquid thermosetting or thermoplastic resin to form a fibre-resin matrix comprising a number of resin-coated fibres, combining the resin-coated fibres and the conductors to form the cable, and pulling the resultant cable through a curing station to cure the fibre-resin matrix. Before the curing station, the resin-coated fibres are passed through a pre-shaper stage where the fibres are arranged with an orientation parallel to each other and to the conductors and are guided through two guiding plates and at least one pre-shaper element.

Abstract: Embodiments of the present invention relate to systems, methods, and apparatus for insulating and/or identifying beverages of a tower beverage dispenser. Particularly, a tower wrap can provide sufficient insulation to a beverage tower of the tower beverage dispenser. For example, the tower wrap can prevent substantial rise in temperature of the beverages located within the beverage tower, while the beverage passes through or remains within the beverage tower.

Abstract: The present invention regards a joint for use in a riser (1) extending between a floating installation (3) and a subsea installation (2). The joint comprises an inner pipe segment (21) and an outer pipe segments (22), arranged moveable relative each other in an axial direction and connectable to respective riser segments, forming a chamber (23) between them with a radially extending piston (24), dividing the chamber (23) in a first chamber part (25) and a second chamber part (26), wherein on of said chamber parts (25) in an initial position of the joint is adapted to contain a mainly incompressible fluid, this chamber part (25) decreasing in volume as the inner pipe segment (21) is moved relatively out of the outer pipe segment (22).

Abstract: A device is described for supporting a riser (10) which is suspended from a vessel (1). The riser is suspended via a gimbal. According to the invention the gimbal consists of two frame parts (26, 28) surrounding an intermediate tubular ring (30) which is filled with a fluid. Substantial bending moments on the riser due to the vessel's movements can thereby be avoided.

Abstract: The present invention relates to a riser joint for a riser with a joint connecting two parts of a riser where the two parts are allowed angular displacement. According to the invention the riser joint comprises means for connection to the two parts of the riser at a distance from the joint, and means for adding a force between the two parts. The invention also relates to a method for reducing bending moments in a riser at a connection between the riser and a subsea installation.