Patents by Inventor Paul Caubere
Paul Caubere has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20150306056Abstract: The present invention relates to a docosahexaenoic acid ester including an alcohol selected from among the group made up of nicotinol, panthenol, inositol, isosorbide, and isosorbide mononitrate, or one of the pharmaceutically acceptable salts, enantiomers, diastereoisomers, or mixtures thereof, including racemic mixtures, for the use thereof as a drug for the prophylactic and/or curative treatment of drepanocytosis.Type: ApplicationFiled: November 27, 2013Publication date: October 29, 2015Applicant: PIERRE FABRE MEDICAMENTInventors: Jean-Paul CAUBERE, Frédérique LANTOINE-ADAM
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Patent number: 6127369Abstract: A compound selected from those of formula (I): ##STR1## wherein: X represents N, C or CH,Y represents N when X represents C or CH, or Y represents C or CH when X represents N,R.sub.1 represents an optionally substituted alkyl,R.sub.2 and R.sub.3, which may be identical or different, represent Z or W, as defined in the description,their isomers and addition salts thereof with a pharmaceutically-acceptable acid or base, and medicinal products containing the same which are useful in the treatment of cancer.Type: GrantFiled: June 11, 1999Date of Patent: October 3, 2000Assignee: Adir et CompagnieInventors: Paul Caubere, Gerald Guillaumet, Ivan Rodriguez, Karine Vinter-Pasquier, Catherine Kuehm-Caubere, Stephanie Blanchard, Ghanem Atassi, Alain Pierre, Bruno Pfeiffer, Pierre Renard
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Patent number: 5696279Abstract: Thiocyanoalkyl esters of hydroxy-substituted (meth)acrylic acids are prepared by a process which includes the step of reacting an acrylic compound with an aldehyde of the formula CHOHR' wherein R' is a straight-chain or branched alkyl optionally substituted by hydroxyl, alkoxy or ester substitutents; straight-chain, branched or cyclic alkenyl; aryl radicals, optionally substituted by halogen, nitro or alkoxy, unsaturated heterocyclic radicals; alkylaryl; or arylalkyl radicals.Type: GrantFiled: October 20, 1995Date of Patent: December 9, 1997Assignee: AtochemInventors: Marie-Christine Berthe, Paul Caubere, Yves Fort
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Patent number: 5635516Abstract: A compound selected from those of formula (I): ##STR1## in which R.sub.1, R.sub.2, R.sub.3 and A are as defined in the description.Type: GrantFiled: June 27, 1995Date of Patent: June 3, 1997Assignee: Adir et CompagnieInventors: Paul Caubere, Brigitte Jamart-Gregoire, Catherine Caubere, Dominique Manechez, Pierre Renard, Gerard Adam, Catherine Nguyen
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Patent number: 5565597Abstract: A process for the preparation of an acrylic or methacrylic compound of formula (I): ##STR1## wherein R is a hydrogen atom or methyl and n is an integer ranging from 2 to 20 inclusive, comprising reacting a halogeno-n-alkyl acrylate or methacrylate of the formula: ##STR2## in which n is as defined above and X is a halogen atom, with a thiocyanate salt in an organic solvent and in the presence of an effective phase-transferring amount of at least one phase-transfer agent.Type: GrantFiled: March 27, 1995Date of Patent: October 15, 1996Assignee: AtochemInventors: Marie-Christine Berthe, Paul Caubere, Yves Fort
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Patent number: 5556974Abstract: Monomers of the formulae: ##STR1## and ##STR2## as well as polymers and copolymers thereof wherein n=2-20; R=H, CH.sub.3 or CHOHR' where R'=straight-chain or branched alkyl, optionally substituted by hydroxyl, alkoxy or ester substituents, straight-chain, branched or cyclic alkenyl, aryl, optionally substituted by halogenated, nitro or alkoxy substituents, unsaturated heterocycle, alkylaryl and arylalkyl, R=CH.sub.3 in formula (I) in the case of monomers and homopolymers wherein n=2 and in the case of monomers wherein n=4.Type: GrantFiled: October 20, 1995Date of Patent: September 17, 1996Assignee: AtochemInventors: Marie-Christine Berthe, Paul Caubere, Yves Fort
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Patent number: 5536845Abstract: Process for the preparation of the acrylates chosen from those of formula ##STR1## those of formula ##STR2## and those of the formula ##STR3## useful in the production of new polymers and copolymers.Type: GrantFiled: April 21, 1994Date of Patent: July 16, 1996Assignee: AtochemInventors: Marie-Christine Berthe, Paul Caubere, Yves Fort
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Patent number: 5510516Abstract: An unsaturated (meth) acrylic compound of formula: ##STR1## (X=O, S, NH, NR.sup.3 (R.sup.3 =C.sub.1-12 -alkyl) or O--(CH.sub.2).sub.n (where n=1-16 approximately); R.sup.2 =C.sub.2-20 straight-chain or branched alkyl, monocyclic or polycyclic cycloalkyl or heterocycloalkyl, or alkylaryl hydrocarbon chain, comprising an olefinic double bond in the chain, or at the end of the chain in the case of alkyl or alkylaryl, or an exocyclic or endocyclic olefinic double bond in the case of monocyclic or polycyclic cycloalkyl or heterocycloalkyl; and R.sup.1 =H or C.sub.1-5 -alkyl), is reacted at 10.degree.-60.degree. C. with at least one oxidising compound (hydrogen peroxide) in the presence of at least one catalyst (alkali metal molybdates and tungstates) and in the presence of at least one phase transfer agent and when R.sup.2 =polycyclic cycloalkyl or hetercycloalkyl, an organic peracid or hydrogen peroxide in the presence of at least one heteropolyacid.Type: GrantFiled: May 4, 1993Date of Patent: April 23, 1996Assignee: ATOCHEMInventors: Paul Caubere, Yves Fort, Agnes Ortar
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Patent number: 5491163Abstract: The invention relates to a compound selected from those of formula (I): ##STR1## in which R.sub.1, R.sub.2, R.sub.3 and A are as defined in the description, and medicinal product containing the same in order to treat a mammal afflicted with a peroxydation phenomenom.Type: GrantFiled: July 19, 1994Date of Patent: February 13, 1996Assignee: Adir et CompagnieInventors: Paul Caubere, Brigitte Jamart-Gregoire, Catherine Caubere, Jean-Guy Bizot-Espiard, Pierre Renard, Gerard Adam
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Patent number: 5481012Abstract: Process for the epoxidation of an unsaturated (meth)acrylic compound of formula: ##STR1## in which R.sub.1 is chosen from H and C.sub.1 -C.sub.5 -alkyl; R.sub.2 is chosen from H, alkyl and aryl; R.sub.3 is a straight-chain, branched or cyclic alkylene or oxyalkylene radical having from 1 to 12 carbon atoms, it being possible for one of the carbon atoms of R.sub.2, when the latter is an alkyl radical, to be linked to one of the carbon atoms of R.sub.3 to form a ring; and A is chosen from O, S, NH and NR.sub.4, R.sub.4 being a C.sub.1 -C.sub.12 -alkyl group; by the action of hydrogen peroxide on the said unsaturated (meth)acrylic compound, at a temperature of between 10.degree. C. and 50.degree. C., in the presence of at least one catalyst chosen from the alkali metal molybdates and the alkali metal pertungstates and in the presence of at least one phase transfer agent.Type: GrantFiled: November 3, 1994Date of Patent: January 2, 1996Assignee: AtochemInventors: Paul Caubere, Yves Fort, Agnes Ortar
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Patent number: 5468856Abstract: Monomers of the formulae: ##STR1## as well as polymers and copolymers thereof wherein n=2-20; R=H, CH.sub.3 or CHOHR' where R'=straight-chain or branched alkyl, optionally substituted by hydroxyl, alkoxy or ester substituents, straight-chain, branched or cyclic alkenyl, aryl, optionally substituted by halogenated, nitro or alkoxy substituents, unsaturated heterocycle, alkylaryl and arylalkyl, R=CH.sub.3 in formula (I) in the case of monomers and homopolymers wherein n=2 and in the case of monomers wherein n=4.Type: GrantFiled: March 17, 1994Date of Patent: November 21, 1995Assignee: AtochemInventors: Marie-Christine Berthe, Paul Caubere, Yves Fort
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Patent number: 5442080Abstract: The invention concerns a process of preparation of the polyazido alcohols by reaction of a polysubstituted oxirane having in position .beta. a nucleofuge group with a metal nitride, characterized in that the reaction is performed in an aqueous medium.The oxirane formula is: ##STR1## in which X represents a nucleofuge substituent, R1 represents an atom of hydrogen, a lower alkyl group substituted or not by a halogen, an aryl group possibly substituted, R2 and R3 represent an atom of hydrogen, a lower alkyl radical possibly substituted, an aryl group possibly substituted, R4 represents an atom of hydrogen, a lower alkyl group possibly substituted, an aryl group possibly substituted by an alkoxy group. Application to the preparation of polyamino alcohols, ureas, polyazidothiols and binding compositions for propergols.Type: GrantFiled: November 23, 1992Date of Patent: August 15, 1995Assignee: Etat Francais represente par le Delegue General pour l'ArmementInventors: Paul Caubere, Herve Forconi
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Patent number: 5332850Abstract: Monomers of the formulae: ##STR1## as well as polymers and copolymers thereof wherein n=2-20; R=H, CH.sub.3 or CHOHR' where R'=straight-chain or branched alkyl, optionally substituted by hydroxyl, alkoxy or ester substituents, straight-chain, branched or cyclic alkenyl, aryl, optionally substituted by halogenated, nitro or alkoxy substituents, unsaturated heterocycle, alkylaryl and arylalkyl, R=CH.sub.3 in formula (I) in the case of monomers and homopolymers wherein n=2 and in the case of monomers wherein n=4.Type: GrantFiled: July 9, 1991Date of Patent: July 26, 1994Assignee: AtochemInventors: Marie-Christine Berthe, Paul Caubere, Yves Fort
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Patent number: 5332836Abstract: Acrylates of the formula ##STR1## in which: R is a radical chosen from alkyl radicals containing from 1 to 12 carbon atoms, cycloalkyl radicals containing from 5 to 12 carbon atoms, and aryl, arylalkyl and alkylaryl radicals,Z is a hydrocarbon radical containing at least two carbon atoms forming with the oxygen and the two adjacent carbons a ring containing from 4 to 8 members.Type: GrantFiled: February 25, 1993Date of Patent: July 26, 1994Assignee: AtochemInventors: Marie-Christine Berthe, Paul Caubere, Yves Fort
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Patent number: 5283360Abstract: An unsaturated (meth)acrylic compound of formula: ##STR1## (X.dbd.O, S, NH, NR.sup.3 (R.sup.3 =C.sub.1-12 -alkyl) or O--(CH.sub.2).sub.n (where n=1-16 approximately); R.sup.2 =C.sub.2-20 straight-chain or branched alkyl, monocyclic or polycyclic cycloalkyl or heterocycloalkyl, or alkylaryl hydrocarbon chain, comprising an olefinic double bond in the chain, or at the end of the chain in the case of alkyl or alkylaryl, or an exocyclic or endocyclic olefinic double bond in the case of monocyclic or polycyclic cycloalkyl or heterocycloalkyl; and R.sup.1 =H or C.sub.1-5 -alkyl), is reacted at 10.degree.-60.degree. C. with at least one oxidizing compound (hydrogen peroxide) in the presence of at least one catalyst (alkali metal molybdates and tungstates) and in the presence of at least one phase transfer agent and when R.sup.2 =polycyclic cycloalkyl or hetercycloalkyl, an organic peracid or hydrogen peroxide in the presence of at least one heteropolyacid.Type: GrantFiled: July 8, 1991Date of Patent: February 1, 1994Assignee: AtochemInventors: Paul Caubere, Yves Fort, Agnes Ortar
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Patent number: 5206389Abstract: These acrylates are those of formulae: ##STR1## where R=C.sub.1 -C.sub.12 alkyl, C.sub.5 -C.sub.12 cycloalkyl, aryl, arylalkyl or alkylaryl; Y=C.sub.1 -C.sub.12 alkyl, C.sub.6 -C.sub.12 aryl, heterocyclic radical whose ring contains from 5 to 10 members and whose heteroatom is chosen from N, O and S, an alkylaryl in which the alkyl part contains from 1 to 4 carbon atoms, Y not being able to denote 1,4-phenylene when R denotes methyl; and Z=hydrocarbon radical containing at least 2 C forming with O and the 2 adjacent Cs a ring containing from 4 to 8 members.To prepare them, an acrylate of formula CH.sub.2 .dbd.CH--COOR is reacted with a dialdehyde OHC--Y--CHO in the presence of an effective quantity of at least one functionalisation catalyst.The invention also relates to the preparation of new polymers and copolymers from the said acrylates.Type: GrantFiled: June 27, 1991Date of Patent: April 27, 1993Assignee: AtochemInventors: Marie-Christine Berthe, Paul Caubere, Yves Fort
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Patent number: 5190671Abstract: The present invention relates to a process for the synthesis of monohaloalkanoylferrocenes of general formula (I) ##STR1## in which X=Cl, Br, n is an integer such that 2.ltoreq.n.ltoreq.7, R.sub.1 and R.sub.2 =H, C.sub.1 -C.sub.8 alkyl chain. A ferrocene derivative of general formula (II) ##STR2## in which R.sub.1 and R.sub.2 have the abovementioned meaning, is reacted at a temperature -5.degree. C.<.theta..sub.r <+15.degree. C., in the presence of AlCl.sub.3 with a halide or the anhydride of an acid of general formula (III) HOOC--(CH.sub.2).sub.n --X, X and n having the abovementioned meaning. An acylating solution obtained by mixing AlCl.sub.2 and the acid halide or anhydride in CH.sub.2 Cl.sub.2, whose temperature .theta..sub.a is such that 5.degree. C..ltoreq..theta..sub.r -.theta..sub.a .ltoreq.15.degree. C., is progressively added to a solution of the ferrocene derivative (II) in CH.sub.2 Cl.sub.2. The molar ratio of the acid halide or anhydride to the ferrocene derivative is between 0.99 and 1.Type: GrantFiled: October 2, 1991Date of Patent: March 2, 1993Assignee: Societe Nationale des Poudres et ExplosifsInventors: Paul Caubere, Yves Fort, Jean-Claude Gautier, Jean-Claude Mondet
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Patent number: 4970319Abstract: The invention relates to a process for the preparation of acyl isocyanates of formula ##STR1## in which R is an alkyl radical, a substituted or unsubstituted naphthyl or phenyl radical or a substituted or unsubstituted aromatic heterocyclic radical, which consists in reacting an acyl halide of formula ##STR2## in which R has the above meaning and X denotes a fluorine, chlorine or bromine atom, with a sodium or potassium cyanate in the presence of a compound chosen from tin(IV), zinc or nickel(II) halides.The acyl isocyanates thus prepared are very useful for forming ureas or carbamates.Type: GrantFiled: March 23, 1989Date of Patent: November 13, 1990Assignee: Societe Nationale des Poudres et ExplosifsInventors: Jean-Pierre Senet, Serge Lecolier, Paul Caubere, Deng Min-Zhi