Patents by Inventor Paul Charifson

Paul Charifson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibitors of bacterial IMPDH
    Publication number: 20070191434
    Abstract: The present invention relates to methods of inhibiting bacterial IMPDH comprising administering compounds of formula I: or pharmaceutically acceptable salts thereof. The present invention also relates to pharmaceutically acceptable compositions comprising said compounds. These compounds, and compositions thereof, are useful in treating bacterial infections.
    Type: Application
    Filed: September 8, 2006
    Publication date: August 16, 2007
    Inventors: Paul Charifson, Trudy Grossman, Emanuele Perola
  • Modulators of muscarinic receptors
    Publication number: 20060270653
    Abstract: The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.
    Type: Application
    Filed: November 29, 2005
    Publication date: November 30, 2006
    Inventors: Ioana Drutu, Dennis Hurley, Upul Bandarage, Daniele Bergeron, Paul Charifson, Robert Davies, Miguel Blanco, Lewis Makings, Akiko Nakatani, Gabriel Raffai
  • Gyrase inhibitors and uses thereof
    Publication number: 20060122196
    Abstract: The present invention relates to compounds that inhibit bacterial gyrase and/or Topo IV and pharmaceutically acceptable compositions comprising said compounds. These compounds, and compositions thereof, are useful in treating bacterial infection. Accordingly, the present invention also relates to methods for treating bacterial infections in mammals.
    Type: Application
    Filed: October 21, 2004
    Publication date: June 8, 2006
    Inventors: Paul Charifson, David Deininger, Anne-Laure Grillot, Yusheng Liao, Steven Ronkin, Dean Stamos, Emanuele Perola, Tiansheng Wang, Arnaud LeTiran, Joseph Drumm
  • Gyrase inhibitors and uses thereof
    Publication number: 20060025424
    Abstract: The present invention relates to compounds that inhibit bacterial gyrase and/or Topo IV and pharmaceutically acceptable compositions comprising said compounds. These compounds, and compositions thereof, are useful in treating bacterial infection. Accordingly, the present invention also relates to methods for treating bacterial infections in mammals.
    Type: Application
    Filed: October 21, 2004
    Publication date: February 2, 2006
    Inventors: Paul Charifson, David Deininger, Anne-Laure Grillot, Yusheng Liao, Steven Ronkin, Dean Stamos, Emanuele Perola, Tiansheng Wang, Arnaud LeTiran, Joseph Drumm
  • Gyrase inhibitors and uses thereof
    Publication number: 20050256136
    Abstract: The present invention relates to methods of treating, preventing, or lessening the severity of resistant bacterial infections in mammals, utilizing compounds of formula I or formula VII or pharmaceutically salts thereof. The present invention also relates to methods of using compounds of formula I or formula VII in combination with one or more additional antibacterial agents and/or one or more additional therapeutic agents that increase the susceptibility of bacterial organisms to antibiotics.
    Type: Application
    Filed: November 11, 2004
    Publication date: November 17, 2005
    Inventors: Paul Charifson, David Deininger, Anne-Laure Grillot, Yusheng Liao, Steven Ronkin, Dean Stamos, Emanuele Perola, Tiansheng Wang, Arnaud LeTiran, Joseph Drumm
  • Gyrase inhibitors and uses thereof
    Patent number: 6930116
    Abstract: The present invention relates to compounds of the formula I: where Ring A is a thiazole, oxazole, imidazole or pyrazole and the substituents are as described in the specification, and pharmaceutically acceptable salts thereof. The compounds inhibit bacterial gyrase activity and therefore are useful for treating bacterial infections in mammals.
    Type: Grant
    Filed: March 24, 2003
    Date of Patent: August 16, 2005
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Paul Charifson, Dean Stamos, Michael Badia, Anne Laure Grillot, Steven Ronkin, Martin Trudeau
  • Gyrase inhibitors and uses thereof
    Publication number: 20050038247
    Abstract: The present invention relates to compounds that inhibit bacterial gyrase and/or Topo IV and pharmaceutically acceptable compositions comprising said compounds. These compounds, and compositions thereof, are useful in treating bacterial infection. Accordingly, the present invention also relates to methods for treating bacterial infections in mammals.
    Type: Application
    Filed: July 29, 2004
    Publication date: February 17, 2005
    Inventors: Paul Charifson, David Deininger, Anne-Laure Grillot, Yusheng Liao, Steven Ronkin, Dean Stamos, Emanuele Perola, Tiansheng Wang, Arnaud LeTiran, Joseph Drumm
  • Gyrase inhibitors and uses thereof
    Publication number: 20040043989
    Abstract: The present invention relates to compounds of the formula I: 1
    Type: Application
    Filed: May 23, 2003
    Publication date: March 4, 2004
    Inventors: Anne-Laure Grillot, Paul Charifson, Dean Stamos, Yusheng Liao, Michael Badia, Martin Trudeau
  • Gyrase inhibitors and uses thereof
    Publication number: 20040024030
    Abstract: The present invention relates to compounds of the formula I: 1
    Type: Application
    Filed: March 24, 2003
    Publication date: February 5, 2004
    Inventors: Paul Charifson, Dean Stamos, Michael Badia, Anne Laure Grillot, Steven Ronkin, Martin Trudeau
  • Gyrase inhibitors and uses thereof
    Patent number: 6632809
    Abstract: The present invention relates to compounds of the formula I: or a pharmaceutically acceptable derivative or prodrug thereof. The compounds are useful as inhibitors of bacterial gyrase activity. The present invention also relates to methods for treating bacterial infections in mammala. The present invention also relates to methods for decreasing bacterial quantity in a biological sample.
    Type: Grant
    Filed: December 12, 2001
    Date of Patent: October 14, 2003
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Anne-Laure Grillot, Paul Charifson, Dean Stamos, Yusheng Liao, Michael Badia, Martin Trudeau
  • Caspase inhibitors and uses thereof
    Patent number: 6632962
    Abstract: This invention provides novel compounds that are effective as inhibitors of caspase and cellular apoptosis. The invention also provides methods for using the compounds to treat caspase-mediated diseases in mammals. The compounds have the general formula I: wherein X is F or Cl; R1 is COOH, COO(alkyl), or an isostere thereof; and R2 is an aryl group.
    Type: Grant
    Filed: April 3, 2001
    Date of Patent: October 14, 2003
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Julian M. C. Golec, Paul Charifson, Guy Brenchley
  • Gyrase inhibitors and uses thereof
    Publication number: 20030170858
    Abstract: Disclosed herein are compounds comprising the pharmacophore features HBA, HBD, Grp1, and at least two features selected from Grp2, Grp3 or Grp4: 1
    Type: Application
    Filed: July 18, 2002
    Publication date: September 11, 2003
    Inventors: Paul Charifson, Steve Bellon, Dean Stamos, Michael Badia, Anne-Laure Grillot, Steven Ronkin, Mark Murcko, Martin Trudeau
  • Gyrase inhibitors and uses thereof
    Patent number: 6608087
    Abstract: The present invention relates to compounds of the formula I: where Ring A is a thiazole, oxazole, imidazole or pyrazole and the substituents are as described in the specification, and pharmaceutically acceptable salts thereof. The compounds inhibit bacterial gyrase activity and therefore are useful for treating bacterial infections in mammals.
    Type: Grant
    Filed: July 18, 2002
    Date of Patent: August 19, 2003
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Paul Charifson, Dean Stamos, Michael Badia, Anne-Laure Grillot, Steven Ronkin, Martin Trudeau
  • Gyrase inhibitors and uses thereof
    Publication number: 20030119868
    Abstract: The present invention relates to compounds of the formula I: 1
    Type: Application
    Filed: December 12, 2001
    Publication date: June 26, 2003
    Inventors: Anne-Laure Grillot, Paul Charifson, Dean Stamos, Yusheng Liao, Michael Badia, Martin Trudeau
  • Caspase inhibitors and uses thereof
    Publication number: 20020132833
    Abstract: This invention provides novel compounds that are effective as inhibitors of caspase and cellular apoptosis. The invention also provides methods for using the compounds to treat caspase-mediated diseases in mammals.
    Type: Application
    Filed: April 3, 2001
    Publication date: September 19, 2002
    Inventors: Julian M.C. Golec, Paul Charifson, Guy Brenchley
  • Inhibitors of caspases
    Patent number: 6426413
    Abstract: The present invention relates to novel classes of compounds which are caspase inhibitors, in particular interleukin-1&bgr; converting enzyme (“ICE”) inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting caspase activity and consequently, may be advantageously used as agents against interleukin-1-(“IL-1”), apoptosis-, interferon-&ggr; inducing factor-(IGIF), or interferon-&ggr;-(“IFN-&ggr;”) mediated diseases, including inflammatory diseases, autoimmune diseases, destructive bone disorders, proliferative disorders, infectious diseases, and degenerative diseases.
    Type: Grant
    Filed: September 5, 2000
    Date of Patent: July 30, 2002
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Marion W. Wannamaker, Paul Charifson, David J. Lauffer, Michael D. Mullican