Abstract: Disclosed is route planning using a worst-case risk analysis and, if needed, a best-case risk analysis of GNSS coverage. The worst-case risk analysis identifies cuboids or 2d regions through which a vehicle can be routed with assurance that adequate GNSS coverage will be available regardless of the time of day that the vehicle travels. The best-case risk analysis identifies cuboids or 2d regions through which there is adequate coverage at some times during the day. In case path finding using the worst-case risk analysis fails, a best-case risk analysis can be requested and used to find alternate potential path(s). Time dependent forecast data that covers regions along the alternate potential path(s) can be requested and used to route vehicles, including autonomous drones, from starting points to destinations. This includes generation, distribution and use of risk analysis data, implemented as methods, systems and articles of manufacture.

Abstract: A computer-implemented method for tracking, on a blockchain, at least two clients interacting with an asset, wherein the blockchain comprises a set of transactions associated with the asset, and a set of transactions associated with each client. The asset tracking comprising receiving an asset interaction event request comprising data based on at least two clients associated with an asset interaction event and data indicative of the asset, generating an event transaction based on a reference to the set of transactions associated with the asset and references to the sets of transactions associated with the at least two clients, and submitting the event transaction to the blockchain.

Abstract: The present invention relates to compounds that are MALT1 inhibitors. The compounds have the structural formula I defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of diseases or disorders associated with MALT1.

Abstract: A consolidator system for processing feed materials includes a reactor vessel having a sealed process chamber, a rotatable indexing table in the process chamber having a plurality separate melting hearths; a melting system in thermal communication with the melting hearths configured to melt a feed material in the melting hearths into a molten metal; a feeding system configured to feed the feed material into the melting hearths; and a collection system configured to collect consolidated metal pucks from the melting hearths. The consolidator system also includes a fluid cooling system in fluid communication with the melting hearths configured to cool the feed material into molten form into the consolidated metal pucks in solid form. The consolidator system also includes a sensing system and a control system configured to control the feeding system, the indexing table and the melting system using input from the sensing system.

Abstract: There is provided a computer implemented method. The method provides a generation of a proof of existence data structures. The method comprising: (i) receiving a request comprising a data reveal path, the data reveal path referencing a node of interest within an input hierarchical data structure (ii) obtaining the input hierarchical data structure comprising an input root node and a plurality of input nodes, wherein each of the input nodes within the input hierarchical data structure have an associated value, and (iii) generating an output hierarchical data structure based on the data reveal path and the input hierarchical data structure, wherein the output hierarchical data structure comprises a plurality of output nodes. There is also provided a method for verification of the proof of existence.

Abstract: Disclosed is determining GNSS satellite position visibility by possessing an orbital segment representing the transit of a satellite in orbit over time, a coarse ray angle interval, a fine ray angle interval, and a digital surface model. Disclosed is propagating coarse ray at coarse ray angle intervals increments in a first pass between an observable point and orbital segment at a respective coarse ray angle to determine whether the coarse ray is obstructed by features of the DSM, and recording a status of the coarse ray based on whether the coarse ray was obstructed. If pairs of successive coarse rays have different status, designating the coarse ray with NLOS visibility, then performing a second pass by propagating, per each designated coarse ray, fine rays at fine ray angle intervals, and saving an indication of time at which LOS visibility to the satellite is obstructed.

Abstract: The present disclosure relates to medicament injection devices. An injection device includes: a movable dosage programming component comprising a rotary encoder system having a predefined angular periodicity, a sensor arrangement including a first optical sensor configured to detect movement of the movable dosage programming component relative to the sensor arrangement during dosing of a medicament, wherein the first optical sensor is configured to operate in a strobe-sampling mode at a first frequency, a second optical sensor configured to detect movement of the rotary encoder system relative to the second optical sensor wherein the second optical sensor is configured to operate in a strobe-sampling mode at a second frequency lower than the first frequency, and a processor arrangement configured to, based on the detected movement, determine a medicament dosage administered by the injection device.

Abstract: This disclosure discloses various brackets with various mounting interfaces for engaging (e.g., mechanically) with various surfaces that are correspondingly configured. For example, one of such brackets can clamp onto a bar (e.g., a handlebar of a vehicle) and then an electronic device (e.g., a smartphone, a tablet, a dedicated navigational unit) can removably secure (e.g., mate) to that bracket. This form of removable securing can be via that bracket having a latch configured to engage a detent of the electronic device (or vice versa) in order to linearly mount the electronic device onto the bracket (or vice versa) and disengage the detent in order rotationally unmount the electronic device from the bracket (or vice versa).

Abstract: Disclosed herein are switching or other active FET configurations that implement a branch design with one or more interior FETs of a main path coupled in parallel with one or more auxiliary FETs of an auxiliary path. Such designs include a circuit assembly for performing a switching function that includes a branch with a plurality of auxiliary FETs coupled in series and a main FET coupled in parallel with an interior FET of the plurality of auxiliary FETs. The body nodes of the FETs can be interconnected and/or connected to a body bias network. The body nodes of the FETs can be connected to body bias networks to enable individual body bias voltages to be used for individual or groups of FETs.

Abstract: This disclosure provides systems, apparatuses, and methods for liquid transfer and performing reactions. In one aspect, a system includes a liquid transfer device having a housing having a pipette tip and a plunger assembly; and a reaction chamber, wherein the housing of the liquid transfer device is configured to sealably engage with the reaction chamber. In another aspect, a liquid transfer device including a housing having a pipette tip; and a plunger assembly disposed within the housing and the pipette tip, wherein a portion of the plunger assembly is configured to engage a fluid reservoir such that the plunger assembly remains stationary relative to the fluid reservoir and the housing moves relative to the plunger assembly.

Abstract: Disclosed is reducing starting time for a GNSS receiver that has an imprecise initial starting location by requesting starting assistance from a CDN that caches predictive data including first data indicated predicted LOS visibility from the receiver to individual satellites, wherein the request includes the imprecise initial staring location, receiving, from the CDN, data that includes a first block of the predictive data for the imprecise initial staring location and further adjoining second blocks of predictive data for areas surrounding the imprecise staring location, determining, by the GNSS receiver, commonly available satellites that have visibility from locations in both the first block and the second block, and calculating a first starting position using weighted values for the satellites, the commonly available satellites having higher weighted value than satellites without visibility in both locations, whereby position uncertainty of the first starting position is reduced from the imprecise initial

Abstract: Disclosed is a bicyclic 1H-benzo[d]imidazol-2-yl ester compound that may be useful for reducing nitrous oxide (N2O) emissions and/or reducing nitrate (NO3) leaching, from a nitrogen containing substrate, e.g., from soil. Also disclosed are a liquid agricultural composition and a coated fertiliser composition comprising a bicyclic 1H-benzo[d]imidazol-2-yl ester compound, and a method of reducing N2O emissions and/or NO3 leaching from a nitrogen containing substrate.

Abstract: Embodiments of the invention relate to a computer-implemented method and system for generating personalized recommendations for a target user based at least on stored data about the target user. The method comprises obtaining, at the server computer, data from a plurality of data sources, including entity data associated with a plurality of entities, stored in an entity database, or personal data associated with a plurality of users, stored in a user database. The personalized recommendations system then merges the entity data or personal data and maps the entity or personal data to a corresponding entity or target user, respectively. The entity or personal data is differentiated, a relevance is determined, a weight is assigned to the data and corresponding source to canonicalize the data, the respective databases are updated with the corresponding data, and then a set of personalized recommendations to the target user is generated using the updated databases.

Abstract: A powder feeder system for a foundry system having a mixing hearth includes a housing assembly, and a feeder assembly in the housing assembly having a moveable barrel feeder for feeding a pre-weighed charge of metal powder into the mixing hearth of the foundry system during operation thereof. A method for recycling metal powder includes the steps of melting a content of the mixing hearth completely; and then feeding the metal powder into the mixing hearth while the contents of the mixing hearth are still molten using the powder feeder system.

Abstract: A detergent product containing a detergent composition is provided.

Abstract: Provided are compounds of Formula (I): wherein R1, R2, X, Ring A, Ring B, and Ring C are as defined herein. Compounds of Formula (I) are useful as inhibitors of DNA-PK. Also provided are pharmaceutical compositions comprising said compounds and methods of using the compounds and compositions in the treatment of various diseases, conditions, and disorders.

Abstract: In an aspect a method of manufacturing a ceiling panel is described. The method may include: combining a binding agent with plastic flakes; passing the plastic flakes and the binding agent to a lamination machine; applying a force to the binding agent and the plastic flakes using the lamination machine to create a plastic sheet; and adding a decorative ceiling treatment to a first side of the plastic sheet.

Abstract: Embodiments of the invention include forming a first transistor having first nanosheets, first dipole gate dielectric material being formed around the first nanosheets. An aspect includes forming a second transistor comprising second nanosheets, second dipole gate dielectric material being formed around the second nanosheets, the first and second transistors being in a vertical stack, a first spacing between the first nanosheets being different from a second spacing between the second nanosheets. An aspect includes forming a workfunction metal stack having a first workfunction metal and a second workfunction metal, the first and second workfunction metals being formed between the first nanosheets, the first workfunction metal being formed to pinch off in the second spacing between the second nanosheets such that the second workfunction metal is absent in the second spacing between the second nanosheets.

Abstract: The present disclosure relates to methods of treating a patient with a cancer by administering to the patient a composition comprising CAR T cells and administering to the patient a small molecule linked to a targeting moiety by a linker. The disclosure also relates to compositions for use in such methods.