Patents by Inventor Paul Charles Melanson
Paul Charles Melanson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11422133Abstract: A centripetal microfluidic platform comprised of a microfluidics disc and a reader for testing LAL-reactive substances in fluid samples is provided. The microfluidic disc may comprise at least two testing areas wherein each testing area includes a reservoir portion for receiving at least one fluid sample. The disc may comprise a distribution network portion in fluid communication with the reservoir portion. Each distribution network portion may comprise a distribution network of at least four (4) channels, wherein each channel has a metering portion and at least one analysis chamber portion. The analysis chamber portion may comprise a mixing chamber for mixing samples and reagents and an optical chamber portion that is compatible with an optical reader. The metering portion may be sized to meter an aliquot of the fluid sample for analysis in the analysis chamber portion. At least one analysis chamber portion has at least one reagent isolated therein.Type: GrantFiled: October 22, 2019Date of Patent: August 23, 2022Assignee: BL TECHNOLOGIES, INC.Inventors: Paul Charles Melanson, Richard Douglas Godec, Matthew Kaddeland Stonesmith, Darren Barry Smith, Chao Sun
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Publication number: 20200049707Abstract: A centripetal microfluidic platform comprised of a microfluidics disc and a reader for testing LAL-reactive substances in fluid samples is provided. The microfluidic disc may comprise at least two testing areas wherein each testing area includes a reservoir portion for receiving at least one fluid sample. The disc may comprise a distribution network portion in fluid communication with the reservoir portion. Each distribution network portion may comprise a distribution network of at least four (4) channels, wherein each channel has a metering portion and at least one analysis chamber portion. The analysis chamber portion may comprise a mixing chamber for mixing samples and reagents and an optical chamber portion that is compatible with an optical reader. The metering portion may be sized to meter an aliquot of the fluid sample for analysis in the analysis chamber portion. At least one analysis chamber portion has at least one reagent isolated therein.Type: ApplicationFiled: October 22, 2019Publication date: February 13, 2020Inventors: Paul Charles Melanson, Richard Douglas Godec, Matthew Kaddeland STONESMITH, Darren Barry Smith, Chao Sun
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Patent number: 10451622Abstract: A centripetal microfluidic platform comprised of a microfluidics disc and a reader for testing LAL-reactive substances in fluid samples is provided. The microfluidic disc may comprise at least two testing areas wherein each testing area includes a reservoir portion for receiving at least one fluid sample. The disc may comprise a distribution network portion in fluid communication with the reservoir portion. Each distribution network portion may comprise a distribution network of at least four (4) channels, wherein each channel has a metering portion and at least one analysis chamber portion. The analysis chamber portion may comprise a mixing chamber for mixing samples and reagents and an optical chamber portion that is compatible with an optical reader. The metering portion may be sized to meter an aliquot of the fluid sample for analysis in the analysis chamber portion. At least one analysis chamber portion has at least one reagent isolated therein.Type: GrantFiled: September 17, 2018Date of Patent: October 22, 2019Assignee: BL TECHNOLOGIES, INC.Inventors: Paul Charles Melanson, Richard Douglas Godec, Matthew Kaddeland Stonesmith, Darren Barry Smith, Chao Sun
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Preloaded test substrates for testing LAL-reactive substances, methods of use, and methods of making
Patent number: 10352934Abstract: A test substrate for detecting a LAL-reactive substance, wherein at least a portion of said test substrate has been preloaded with at least one LAL reagent and/or at least one LAL-reactive standard. Methods of use of the test substrate are disclosed. Methods of depositing test reagents on a test substrate are also disclosed.Type: GrantFiled: September 28, 2017Date of Patent: July 16, 2019Assignee: GENERAL ELECTRIC COMPANYInventors: Richard Douglas Godec, Paul Charles Melanson, Matthew Kaddeland Stonesmith, Hong Xu, Yan Huang -
Patent number: 10302642Abstract: Methods and systems for measuring the concentration of LAL-reactive substances in fluid samples is provided. They include contacting an aqueous sample with a detection reagent to form a prepared sample. A physical property of the prepared sample may be measured to obtain at least one sample measurement characteristic of the prepared sample. Curve fitting may then be used to forecast a concentration of the LAL-reactive substance the aqueous sample will have at a specified time in the future based on the sample measurement and a correlation developed between at least one standard measurement of a physical quality of a solution with a known concentration of a LAL-reactive substance therein. The quality of the sample measurement may be validated using historical data and/or the standard measurement.Type: GrantFiled: January 30, 2018Date of Patent: May 28, 2019Assignee: GENERAL ELECTRIC COMPANYInventors: Paul Charles Melanson, Vidyasankar Sundaresan, Richard Douglas Godec, Shouquan Deng
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Publication number: 20190018013Abstract: A centripetal microfluidic platform comprised of a microfluidics disc and a reader for testing LAL-reactive substances in fluid samples is provided. The microfluidic disc may comprise at least two testing areas wherein each testing area includes a reservoir portion for receiving at least one fluid sample. The disc may comprise a distribution network portion in fluid communication with the reservoir portion. Each distribution network portion may comprise a distribution network of at least four (4) channels, wherein each channel has a metering portion and at least one analysis chamber portion. The analysis chamber portion may comprise a mixing chamber for mixing samples and reagents and an optical chamber portion that is compatible with an optical reader. The metering portion may be sized to meter an aliquot of the fluid sample for analysis in the analysis chamber portion. At least one analysis chamber portion has at least one reagent isolated therein.Type: ApplicationFiled: September 17, 2018Publication date: January 17, 2019Inventors: Paul Charles Melanson, Richard Douglas Godec, Matthew Kaddeland STONESMITH, Darren Barry Smith, Chao Sun
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Patent number: 10082505Abstract: A centripetal microfluidic platform comprised of a microfluidics disc and a reader for testing LAL-reactive substances in fluid samples is provided. The microfluidic disc may comprise at least two testing areas wherein each testing area includes a reservoir portion for receiving at least one fluid sample. The disc may comprise a distribution network portion in fluid communication with the reservoir portion. Each distribution network portion may comprise a distribution network of at least four (4) channels, wherein each channel has a metering portion and at least one analysis chamber portion. The analysis chamber portion may comprise a mixing chamber for mixing samples and reagents and an optical chamber portion that is compatible with an optical reader. The metering portion may be sized to meter an aliquot of the fluid sample for analysis in the analysis chamber portion. At least one analysis chamber portion has at least one reagent isolated therein.Type: GrantFiled: October 7, 2013Date of Patent: September 25, 2018Assignee: GENERAL ELECTRIC COMPANYInventors: Paul Charles Melanson, Richard Douglas Godec, Matthew Kaddeland Stonesmith, Darren Barry Smith, Chao Sun
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Publication number: 20180156795Abstract: Methods and systems for measuring the concentration of LAL-reactive substances in fluid samples is provided. They include contacting an aqueous sample with a detection reagent to form a prepared sample. A physical property of the prepared sample may be measured to obtain at least one sample measurement characteristic of the prepared sample. Curve fitting may then be used to forecast a concentration of the LAL-reactive substance the aqueous sample will have at a specified time in the future based on the sample measurement and a correlation developed between at least one standard measurement of a physical quality of a solution with a known concentration of a LAL-reactive substance therein. The quality of the sample measurement may be validated using historical data and/or the standard measurement.Type: ApplicationFiled: January 30, 2018Publication date: June 7, 2018Inventors: Paul Charles Melanson, Vidyasankar Sundaresan, Richard Douglas Godec, Shouquan Deng
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Patent number: 9880166Abstract: Methods and systems for measuring the concentration of LAL-reactive substances in fluid samples is provided. They include contacting an aqueous sample with a detection reagent to form a prepared sample. A physical property of the prepared sample may be measured to obtain at least one sample measurement characteristic of the prepared sample. Curve fitting may then be used to forecast a concentration of the LAL-reactive substance the aqueous sample will have at a specified time in the future based on the sample measurement and a correlation developed between at least one standard measurement of a physical quality of a solution with a known concentration of a LAL-reactive substance therein. The quality of the sample measurement may be validated using historical data and/or the standard measurement.Type: GrantFiled: October 7, 2013Date of Patent: January 30, 2018Assignee: General Electric CompanyInventors: Paul Charles Melanson, Vidyasankar Sundaresan, Richard Douglas Godec, Shouquan Deng
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PRELOADED TEST SUBSTRATES FOR TESTING LAL-REACTIVE SUBSTANCES, METHODS OF USE, AND METHODS OF MAKING
Publication number: 20180017562Abstract: A test substrate for detecting a LAL-reactive substance, wherein at least a portion of said test substrate has been preloaded with at least one LAL reagent and/or at least one LAL-reactive standard. Methods of use of the test substrate are disclosed. Methods of depositing test reagents on a test substrate are also disclosed.Type: ApplicationFiled: September 28, 2017Publication date: January 18, 2018Inventors: Richard Douglas Godec, Paul Charles Melanson, Matthew Kaddeland Stonesmith, Hong Xu, Yan Huang -
Patent number: 9678079Abstract: A microfluidic testing cartridge for testing LAL-reactive substances in fluid samples is provided. The cartridge may include at least two (2) testing modules, wherein each testing module includes at least one inlet port for receiving one of the fluid samples, and at least four (4) testing channels in fluid communication with the inlet port. Each of the testing channels may include a metering portion for metering an aliquot of the fluid sample, an analyzing portion, and a mixing portion, wherein a valve is positioned between the metering portion and the analyzing portion to selectively fluidly separate the metering portion from the analyzing portion. The cartridge is insertable into an optical reader which performs optical measurements of the fluid sample within each testing channel during a testing process.Type: GrantFiled: October 7, 2013Date of Patent: June 13, 2017Assignee: GENERAL ELECTRIC COMPANYInventors: Richard Douglas Godec, Paul Charles Melanson, Matthew Kaddeland Stonesmith, Yan Huang, Vidyasankar Sundaresan, Hong Xu, Ruiqing Li, Shouquan Deng
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PRELOADED TEST SUBSTRATES FOR TESTING LAL-REACTIVE SUBSTANCES, METHODS OF USE, AND METHODS OF MAKING
Publication number: 20150293097Abstract: A test substrate for detecting a LAL-reactive substance, wherein at least a portion of said test substrate has been pre-loaded with at least one LAL reagent and/or at least one LAL-reactive standard. Methods of use of the test substrate are disclosed. Methods of depositing test reagents on a test substrate are also disclosed.Type: ApplicationFiled: October 7, 2013Publication date: October 15, 2015Inventors: Richard Douglas Godec, Paul Charles Melanson, Matthew Kaddeland Stonesmith, Hong Xu, Yan Huang -
Publication number: 20150260719Abstract: A microfluidic testing cartridge for testing LAL-reactive substances in fluid samples is provided. The cartridge may comprise at least two (2) testing modules, wherein each testing module includes at least one inlet port for receiving one of the fluid samples, and at least four (4) testing channels in fluid communication with the inlet port. Each of the testing channels may include a metering portion for metering an aliquot of the fluid sample, an analyzing portion, and a mixing portion, wherein a valve is positioned between the metering portion and the analyzing portion to selectively fluidly separate the metering portion from the analyzing portion. The cartridge is insertable into an optical reader which performs optical measurements of the fluid sample within each test ing channel during a testing process.Type: ApplicationFiled: October 7, 2013Publication date: September 17, 2015Inventors: Richard Douglas Godec, Paul Charles Melanson, Matthew Kaddeland Stonesmith, Yan Huang, Vidyasankar Sundaresan, Hong Xu, Ruiqing Li, Shouquan Deng
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Publication number: 20150233916Abstract: A centripetal microfluidic platform comprised of a microfluidics disc and a reader for testing LAL-reactive substances in fluid samples is provided. The microfluidic disc may comprise at least two testing areas wherein each testing area includes a reservoir portion for receiving at least one fluid sample. The disc may comprise a distribution network portion in fluid communication with the reservoir portion. Each distribution network portion may comprise a distribution network of at least four (4) channels, wherein each channel has a metering portion and at least one analysis chamber portion. The analysis chamber portion may comprise a mixing chamber for mixing samples and reagents and an optical chamber portion that is compatible with an optical reader. The metering portion may be sized to meter an aliquot of the fluid sample for analysis in the analysis chamber portion. At least one analysis chamber portion has at least one reagent isolated therein.Type: ApplicationFiled: October 7, 2013Publication date: August 20, 2015Applicant: GENERAL ELECTRIC COMPANYInventors: Paul Charles Melanson, Richard Douglas Godec, Matthew Kaddeland STONESMITH, Darren Barry Smith, Chao Sun
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Publication number: 20150233917Abstract: Methods and systems for measuring the concentration of LAL-reactive substances in fluid samples is provided. They include contacting an aqueous sample with a detection reagent to form a prepared sample. A physical property of the prepared sample may be measured to obtain at least one sample measurement characteristic of the prepared sample. Curve fitting may then be used to forecast a concentration of the LAL-reactive substance the aqueous sample will have at a specified time in the future based on the sample measurement and a correlation developed between at least one standard measurement of a physical quality of a solution with a known concentration of a LAL-reactive substance therein. The quality of the sample measurement may be validated using historical data and/or the standard measurement.Type: ApplicationFiled: October 7, 2013Publication date: August 20, 2015Applicant: GENERAL ELECTRIC COMPANYInventors: Paul Charles Melanson, Vidyasankar Sundaresan, Richard Douglas Godec, Shouquan Deng