Abstract: This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) having core structure (I), pharmaceutical compositions containing at least one such modulator, methods of treatment of CFTR mediated diseases, including cystic fibrosis, using such modulators and pharmaceutical compositions, combination pharmaceutical compositions and combination therapies employing those modulators, and processes and intermediates for making such modulators.

Abstract: An implant includes a frame, and a textile mounted on the frame. The textile includes fibers formed from a mixture of a polymer and an additive molecule. The additive molecule includes a polyurethane backbone and one or more fluorinated end-groups at at least one end of the backbone. Other embodiments are also described.

Abstract: A compact key input apparatus interface includes a resistive element and a number of key contacts on the resistive element. The keys of a key input apparatus are disposed to provide electrical contact between a voltage source and the resistive element at a particular contact point when a corresponding key is depressed, such that a path from the voltage source to ground is made through the resistive element. The keys are arranged along the length of the resistive element so that the depression of any key provides a different conductive path to ground and therefore a different magnitude of current through the conductive path. A corresponding sense voltage measured at a sampling point provides a single-line input to a key decoder, which determines which key is depressed based on the level of the sense voltage.