Abstract: Described are optical probes for application of laser light to at least the pars plana and optionally other regions, such as the trabecular meshwork, pars plicata, and/or ciliary sulcus, of an eye, such as for treatment of glaucoma, to reduce intraocular pressure (IOP), to improve outflow of aqueous humor from the eye, and/or reduce buildup of aqueous humor within the eye. The optical probes can be adapted for simultaneously treating multiple different regions, tissues, or bodies of the eye, or for sequentially treating multiple different regions, tissues, or bodies of the eye.

Abstract: Conventional ways of reducing pressure in the eye have inherent drawbacks and one such way to reduce these drawbacks is to provide an ocular drainage implant including a pliable plate which is so sized and shaped as to enable it to be positioned on a sclera surface or a sub-scleral space of an eye comprising a first exterior face and a second exterior face, with a plurality of apertures extending between the first and second faces, and a fluid drainage tube retaining structure; and a valve-less fluid drainage tube connected to the retaining structure and providing the implant with a longitudinal axis, the valve-less fluid drainage tube being adapted to drain fluid from an anterior chamber of the eye to the subconjunctival or the suprachoroidal space, wherein the retaining structure extends substantially across an entire dimension of the plate.

Abstract: Aspects of the present disclosure are directed to an ocular drainage device that includes a stability system. The stability system includes a plate, and can further include a material comprising collagen covering at least a portion of a top surface of the plate, and/or a viscoelastic substance covering at least a portion of the plate's top surface. The plate is formed of a flexible material and includes a tube retaining structure integrally formed therewith, wherein the tube retaining structure is configured to hold a tube that is at least partially surrounded by the tube retaining structure to the plate when the tube is moved. The tube retaining structure can include a low profile ridge, and/or a channel having an undercut or horseshoe shape. The plate has at least one plate channel, including a plate channel configured for carrying the tube. The plate can further include a reservoir.

Abstract: Aspects of the present disclosure are directed to an ocular drainage device that includes a stability system. The stability system includes a plate, and can further include a material comprising collagen covering at least a portion of a top surface of the plate, and/or a viscoelastic substance covering at least a portion of the plate's top surface. The plate is formed of a flexible material and includes a tube retaining structure integrally formed therewith, wherein the tube retaining structure is configured to hold a tube that is at least partially surrounded by the tube retaining structure to the plate when the tube is moved. The tube retaining structure can include a low profile ridge, and/or a channel having an undercut or horseshoe shape. The plate has at least one plate channel, including a plate channel configured for carrying the tube. The plate can further include a reservoir.

Abstract: The present invention relates to the use of dronedarone or a pharmaceutically acceptable salt thereof for the preparation of a drug for the prevention of atrial fibrillation wherein said use comprises the following precaution of use steps: a) initiating dronedarone administration in patients with atrial fibrillation or atrial flutter, b) performing electrocardiograms serially.

Abstract: The invention relates to the use of idrabiotaparinux for the treatment and secondary prevention of thrombotic pathologies, wherein the use of idrabiotaparinux involves a decrease in the incidence of bleedings, in particular major bleedings, during said treatment.