Abstract: The present invention relates to multi-domain binding molecules.

Abstract: An object processing system is disclosed that includes an object induction station at which objects are provided for processing, said object induction station including an in-feed conveyor system and at least one perception unit for providing perception data regarding an object, a plurality of destination locations that are arranged in a vertically and horizontally extending array of destination locations, and a carrier system for receiving at least two objects from the in-feed conveyor system of the object induction station and for moving the at least two objects together toward two different destination locations of the plurality of destination locations, the carrier system being adapted for movement in horizontal and vertical directions and including a set of at least two independently actuatable transfer systems such that the at least two objects may be deposited into each of the two different destination locations.

Abstract: Anti-VEGF proteins including the VEGF trap protein aflibercept can be produced to have a low level of an aspartyl protease (e.g., a low level of cathepsin D), such as less than 1 ppm of the aspartyl protease.

Abstract: The present invention relates to soluble multi-domain binding molecules comprising T cell receptors (TCR) having specificity for an antigen, an immunoglobulin Fc domain or an albumin-binding moiety; and an immune effector domain. Such multi-domain binding molecules are advantageous because they display improved half-life while retaining function.

Abstract: The present invention generally pertains to methods of enriching an antibody of interest. In particular, the present invention pertains to the use of Protein A chromatography in the form of a centrifugal column to enrich a therapeutic antibody from an upstream cell culture process for product quality attribute profiling.

Abstract: The present disclosure provides T cell receptor (TCR) fusion proteins comprising a TCR that binds to a GVYDGREHTV (SEQ ID NO:34) HLA-A*02 complex that is covalently linked to a T cell engaging domain that binds a protein expressed on a cell surface of a T cell and an antibody Fc domain, as well as polynucleotides, vectors, kits, host cells, pharmaceutical compositions, methods, and uses related thereto.

Abstract: The present disclosure provides T cell receptor (TCR) fusion proteins comprising a TCR that binds to a GVYDGREHTV (SEQ ID NO:34) HLA-A*02 complex that is covalently linked to a T cell engaging domain that binds a protein expressed on a cell surface of a T cell and an antibody Fc domain, as well as polynucleotides, vectors, kits, host cells, pharmaceutical compositions, methods, and uses related thereto.

Abstract: The present disclosure provides T cell receptor (TCR) fusion proteins comprising a TCR that binds to a GVYDGREHTV (SEQ ID NO:34) HLA-A*02 complex that is covalently linked to a T cell engaging domain that binds a protein expressed on a cell surface of a T cell and an antibody Fc domain, as well as polynucleotides, vectors, kits, host cells, pharmaceutical compositions, methods, and uses related thereto.

Abstract: The present invention provides an antigen binding protein comprising an antigen binding domain that binds to plasmin, wherein the antigen binding protein reduces the activity of plasmin. The invention also provides compositions comprising the antigen binding protein, and uses and method of treatment comprising the same.

Abstract: A carbonation system for a beverage appliance or machine that can include a liquid chamber and a carbonation chamber separated from the liquid chamber by a wall of the carbonation chamber is disclosed herein. In some implementations, the liquid chamber is defined by a liquid tank (e.g., a water tank), and the carbonation chamber is defined by a carbonation tank. The carbonation system can move liquid (e.g., water) from the liquid chamber to the carbonation chamber and introduce carbonating gas (e.g., carbon dioxide) into the carbonation chamber to create a carbonated liquid (e.g., a carbon dioxide water dissolution, such as carbonated water, sparkling water, or seltzer).

Abstract: The present invention relates to antigen binding proteins comprising an antigen binding domain that binds to plasminogen, wherein the antigen binding protein reduces the activation of plasminogen to plasmin, pharmaceutical compositions comprising the same, and methods and uses thereof.

Abstract: A method and apparatus for frothing a beverage, e.g., using a beverage preparing device and an ejector is described. Within a housing of the beverage preparing device, an air supply and steam supply may be arranged to deliver air and steam to an ejector outside of the housing. Beverage liquid may be frothed by providing steam and air, then steam alone to achieve frothing and heating. An ejector may supply a mixture of steam and air and a controller may be used to regulate the flow of steam and air through the ejector. The ejector may have a venturi that uses steam flow to create a low pressure region, which draws air into the ejector.

Abstract: The present invention relates to methods of producing recombinant plasminogen in a mammalian expression system. A method for producing plasminogen, the method comprising (i) providing a host cell comprising a first recombinant polynucleotide encoding plasminogen and a second recombinant polynucleotide encoding a plasminogen activation inhibitor; (ii) culturing said host cell in a suitable culture medium under conditions to effect expression of plasminogen from the first polynucleotide and plasminogen activation inhibitor from the second polynucleotide.

Abstract: The present invention relates to soluble multi-domain binding molecules comprising T cell receptors (TCR) having specificity for an antigen, an immunoglobulin Fc domain or an albumin-binding moiety; and an immune effector domain. Such multi-domain binding molecules are advantageous because they display improved half-life while retaining function.

Abstract: A carbonation system for a beverage appliance or machine that can include a liquid chamber and a carbonation chamber separated from the liquid chamber by a wall of the carbonation chamber is disclosed herein. In some implementations, the liquid chamber is defined by a liquid tank (e.g., a water tank), and the carbonation chamber is defined by a carbonation tank. The carbonation system can move liquid (e.g., water) from the liquid chamber to the carbonation chamber and introduce carbonating gas (e.g., carbon dioxide) into the carbonation chamber to create a carbonated liquid (e.g., a carbon dioxide water dissolution, such as carbonated water, sparkling water, or seltzer).

Abstract: A jacketed structure includes at least one penetrator slug; a jacket surrounding the at least one penetrator slug; and a deformable sleeve surrounding a portion of the at least one penetrator slug and encased by the jacket. The deformable sleeve includes porous material, which absorbs plastic deflection of the jacket during an engraving process with a barrel of a weapon during firing. The at least one penetrator slug includes material having a hardness value greater than a hardness value of the jacket and the deformable sleeve. The deformable sleeve surrounds a rear portion of the at least one penetrator slug. The deformable sleeve surrounds approximately half of the at least one penetrator slug. The deformable sleeve is configured to deform symmetrically during firing of a weapon containing the jacketed structure.

Abstract: Panel assemblies that include a core sandwiched between face sheets made from composite material. A pigmented topcoat layer is applied directly to the composite material without the need for a separate adhesive. The pigmented topcoat layer includes a thermoplastic binder resin/pigment mixture that can be cured with the composite material in a single step. The topcoat may include permanent and/or temporary substrates for carrying the binder resin/pigment mixture and for providing a surface finish to the panel assembly.

Abstract: Panel assemblies that include a core sandwiched between face sheets made from composite material. A pigmented topcoat layer is applied directly to the composite material without the need for a separate adhesive. The pigmented topcoat layer includes a thermoplastic binder resin/pigment mixture that can be cured with the composite material in a single step. The topcoat may include permanent and/or temporary substrates for carrying the binder resin/pigment mixture and for providing a surface finish to the panel assembly.