Patents by Inventor Paul Crivelli
Paul Crivelli has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20210154667Abstract: An apparatus for directing fluid into and out of a fluidic device includes two or more fluid prime channels connected to a fluid inlet of the fluidic device, a flow control valve for each fluid prime channel to control flow between the fluid prime channel and the fluid inlet, one or more outlet channels connected to a fluid outlet of the fluidic device, and a flow control valve for each outlet channel to control flow between the fluid outlet and the associated outlet channel. An apparatus for delivering fluids to a fluid inlet includes a plate that is rotatable about an axis of rotation and a plurality of fluid compartments disposed on the plate, each compartment having a fluid exit port disposed at a common radial distance from the axis of rotation and positioned to align with the fluid inlet as the plate rotates about the axis of rotation.Type: ApplicationFiled: February 2, 2021Publication date: May 27, 2021Applicants: Illumina, Inc., Illumina Cambridge LimitedInventors: Wesley A. Cox-Muranami, Darren Robert Segale, Oliver Jon Miller, Jennifer Olivia Foley, Tarun Kumar Khurana, Paul Crivelli, Gary Watts
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Patent number: 10953399Abstract: An apparatus for directing fluid into and out of a fluidic device includes two or more fluid prime channels connected to a fluid inlet of the fluidic device, a flow control valve for each fluid prime channel to control flow between the fluid prime channel and the fluid inlet, one or more outlet channels connected to a fluid outlet of the fluidic device, and a flow control valve for each outlet channel to control flow between the fluid outlet and the associated outlet channel. An apparatus for delivering fluids to a fluid inlet includes a plate that is rotatable about an axis of rotation and a plurality of fluid compartments disposed on the plate, each compartment having a fluid exit port disposed at a common radial distance from the axis of rotation and positioned to align with the fluid inlet as the plate rotates about the axis of rotation.Type: GrantFiled: January 10, 2019Date of Patent: March 23, 2021Assignees: ILLUMINA, INC., ILLUMINA CAMBRIDGE LIMITEDInventors: Wesley A. Cox-Muranami, Darren Robert Segale, Oliver Jon Miller, Jennifer Olivia Foley, Tarun Kumar Khurana, Paul Crivelli, Gary Watts
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Publication number: 20210031196Abstract: A combination of components in a capillary flow channel use capillary forces to passively control the movement of liquid samples within a microfluidic device. To detect a target, a liquid sample introduced to a proximal portion of capillary channel of a microfluidic device moves by capillary action along the specific components of capillary channel.Type: ApplicationFiled: October 16, 2020Publication date: February 4, 2021Inventors: Erik Mikael OLSSON, Austin DERFUS, Armando TOVAR, Justin DAVIDSON, Tuan DO, Paul CRIVELLI, Matthew WANG
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Patent number: 10835898Abstract: A combination of components in a capillary flow channel use capillary forces to passively control the movement of liquid samples within a microfluidic device. To detect a target, a liquid sample introduced to a proximal portion of a capillary channel of a microfluidic device moves by capillary action along the specific components of capillary channel.Type: GrantFiled: March 17, 2017Date of Patent: November 17, 2020Assignee: Quidel CorporationInventors: Erik Mikael Olsson, Austin Derfus, Armando Tovar, Justin Davidson, Tuan Do, Paul Crivelli, Matthew Wang
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Publication number: 20200254450Abstract: An apparatus includes a fluid reservoir and a laminate fluidic circuit positioned above the fluid reservoir. The laminate fluidic circuit includes two or more layers laminated together to define a substantially planar substrate and one or more channels defined within the substrate. The laminate fluidic circuit includes a flexible conduit defined by a portion of the substrate encompassing an extent of at least one of the channels that is partially separated or separable from the remainder of the substrate. The flexible conduit is deflectable with respect to the planar substrate toward the fluid reservoir such that the flexible conduit fluidly connects the at least one channel to the fluid reservoir.Type: ApplicationFiled: November 14, 2019Publication date: August 13, 2020Applicant: ILLUMINA, INC.Inventors: Paul CRIVELLI, Cyril DELATTRE
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Publication number: 20200122147Abstract: Disclosed are multi-well plate inserts that can be used to separate solid debris, including paper punch containing a blood sample, from a liquid containing target biological molecules, such as nucleic acid molecules and proteins. Also provided are methods of using the insert, for example as part of a method that analyzes target biological molecules.Type: ApplicationFiled: October 31, 2018Publication date: April 23, 2020Inventors: Andrew Joad, Daniel L. Fuller, Paul Crivelli
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Publication number: 20200110108Abstract: An apparatus includes a fluidic circuit, a bypass fluidic circuit, a first set of fluid wells, a second set of fluid wells, a first valve, and a second valve. The first valve operatively associated with the first set of fluid wells such that the first selectively fluidly connects any one of the first set of fluid wells to a first valve outlet. The second valve operatively associated with the fluidic circuit, the bypass fluidic circuit, the first valve outlet, and the second set of fluid wells such that the second valve selectively fluidly connects any one of the second set of fluid wells and the first valve outlet to the fluidic circuit or the first valve outlet to the bypass fluidic circuit.Type: ApplicationFiled: September 26, 2019Publication date: April 9, 2020Applicant: IIIumina, Inc.Inventors: Wesley A. COX-MURANAMI, James OSMUS, Paul CRIVELLI, Bradley Kent DREWS
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Publication number: 20200108390Abstract: A circuit with electrical interconnect for external electronic connection and sensor(s) on a die are combined with a laminated manifold to deliver a liquid reagent over an active surface of the sensor(s). The laminated manifold includes fluidic channel(s), an interface between the die and the fluidic channel(s) being sealed. Also disclosed is a method, the method including assembling a laminated manifold including fluidic channel(s), attaching sensor(s) on a die to a circuit, the circuit including an electrical interconnect, and attaching a planarization layer to the circuit, the planarization layer including a cut out for the die. The method further includes placing sealing adhesive at sides of the die, attaching the laminated manifold to the circuit, and sealing an interface between the die and fluidic channel(s).Type: ApplicationFiled: December 6, 2019Publication date: April 9, 2020Inventors: DARREN SEGALE, HAI TRAN, PAUL CRIVELLI
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Patent number: 10518263Abstract: A circuit with electrical interconnect for external electronic connection and sensor(s) on a die are combined with a laminated manifold to deliver a liquid reagent over an active surface of the sensor(s). The laminated manifold includes fluidic channel(s), an interface between the die and the fluidic channel(s) being sealed. Also disclosed is a method, the method including assembling a laminated manifold including fluidic channel(s), attaching sensor(s) on a die to a circuit, the circuit including an electrical interconnect, and attaching a planarization layer to the circuit, the planarization layer including a cut out for the die. The method further includes placing sealing adhesive at sides of the die, attaching the laminated manifold to the circuit, and sealing an interface between the die and fluidic channel(s).Type: GrantFiled: January 31, 2019Date of Patent: December 31, 2019Assignee: ILLUMINA, INC.Inventors: Darren Segale, Hai Tran, Paul Crivelli
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Publication number: 20190351413Abstract: An instrument includes a reagent management system. The reagent management system includes a plurality of reagent wells, each reagent well operable to contain a reagent of a plurality of reagents positioned therein. The reagent management system is operable to select a flow of reagent from one of the plurality of reagents. A flexible connection includes a laminate stack and includes a first flexible channel in fluid communication with the reagent management system. The first flexible channel is operable to route the flow of reagent therethrough. A flow cell includes a flow channel in fluid communication with the first flexible channel. The flow channel is operable to route the flow of reagent over analytes positioned in the flow channel. The flexible connection enables the flow cell to be moved by the instrument relative to a fixed reference point in the instrument.Type: ApplicationFiled: May 2, 2019Publication date: November 21, 2019Applicant: Illumina, Inc.Inventors: Cyril DELATTRE, Minsoung RHEE, Jeffrey LIU, Wesley COX-MURANAMI, Paul CRIVELLI, Jennifer FOLEY, Darren SEGALE, Jay TAYLOR, Matthew HAGE, Philip PAIK, Erik ALLEGOREN, David HERTZOG, Alex MOROZ-SMIETANA, Xiaoxiao MA, Tsukasa TAKAHASHI, Brandon WESTERBERG
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Publication number: 20190336970Abstract: In one example, a flow cell includes a plurality of inlet ports sized to receive a flow of reagent from one of a plurality of reagents into the flow cell. An outlet port of the flow cell is sized to pass each flow of reagent out of the flow cell. A flow channel of the flow cell is positioned between, and in fluid communication with, each inlet port and the outlet port. The flow channel includes a manifold section and a detection section. The manifold section has a plurality of manifold branches in fluid communication with a common line, wherein each branch is connected to one of each inlet port. The detection section is in fluid communication with the common line and the outlet port. The detection section is operable to perform a plurality of different chemical reactions between the plurality of reagents and analytes positioned in the detection section.Type: ApplicationFiled: May 1, 2019Publication date: November 7, 2019Applicant: Illumina, Inc.Inventors: Sz-Chin LIN, Jay TAYLOR, Minsoung RHEE, Jennifer FOLEY, Wesley COX-MURANAMI, Cyril DELATTRE, Tarun KHURANA, Paul CRIVELLI
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Publication number: 20190337690Abstract: A method is provided comprising loading shells into shell retention chambers of a shell management module, the shells including corresponding reservoirs configured to hold individual quantities of liquid, the shell retention chambers arranged in a predetermined pattern on a platform of the shell management module. The method further comprises orienting discharge ends of the shells along an actuation direction within the shell retention chambers, and covering the discharge ends with closure lids to seal bottoms of the corresponding reservoirs.Type: ApplicationFiled: July 12, 2019Publication date: November 7, 2019Inventors: Paul Crivelli, Gary Watts
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Patent number: 10377538Abstract: A liquid storage and delivery mechanism and method of use are provided. The mechanism comprises shells that include corresponding reservoirs to hold individual quantities of liquid. The shells include filling ends and discharge ends. The filling ends include fill ports that open to the reservoirs in order to receive the corresponding quantity of liquid. The discharge ends are covered with closure lids to seal bottoms of the corresponding reservoirs. A shell management module is provided comprising a cover and a platform. The platform includes shell retention chambers to receive corresponding shells. The shell retention chambers are arranged in a predetermined pattern on the platform. The shell retention chambers are to orient shells with the fill ports exposed from the platform. The cover is mounted onto the platform to close the fill ports. The shells are to move individually, along the shell retention chambers, between non-actuated and actuated positions.Type: GrantFiled: November 30, 2016Date of Patent: August 13, 2019Assignee: Illumina, Inc.Inventors: Paul Crivelli, Gary Watts
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Publication number: 20190240660Abstract: A circuit with electrical interconnect for external electronic connection and sensor(s) on a die are combined with a laminated manifold to deliver a liquid reagent over an active surface of the sensor(s). The laminated manifold includes fluidic channel(s), an interface between the die and the fluidic channel(s) being sealed. Also disclosed is a method, the method including assembling a laminated manifold including fluidic channel(s), attaching sensor(s) on a die to a circuit, the circuit including an electrical interconnect, and attaching a planarization layer to the circuit, the planarization layer including a cut out for the die. The method further includes placing sealing adhesive at sides of the die, attaching the laminated manifold to the circuit, and sealing an interface between the die and fluidic channel(s).Type: ApplicationFiled: January 31, 2019Publication date: August 8, 2019Inventors: Darren Segale, Hai Tran, Paul Crivelli
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Publication number: 20190224676Abstract: An apparatus for directing fluid into and out of a fluidic device includes two or more fluid prime channels connected to a fluid inlet of the fluidic device, a flow control valve for each fluid prime channel to control flow between the fluid prime channel and the fluid inlet, one or more outlet channels connected to a fluid outlet of the fluidic device, and a flow control valve for each outlet channel to control flow between the fluid outlet and the associated outlet channel. An apparatus for delivering fluids to a fluid inlet includes a plate that is rotatable about an axis of rotation and a plurality of fluid compartments disposed on the plate, each compartment having a fluid exit port disposed at a common radial distance from the axis of rotation and positioned to align with the fluid inlet as the plate rotates about the axis of rotation.Type: ApplicationFiled: January 10, 2019Publication date: July 25, 2019Applicants: Illumina, Inc., Illumina Cambridge LimitedInventors: Wesley A. COX-MURANAMI, Darren Robert SEGALE, Oliver Jon MILLER, Jennifer Olivia FOLEY, Tarun Kumar KHURANA, Paul CRIVELLI, Gary WATTS
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Publication number: 20190118181Abstract: A combination of components in a capillary flow channel use capillary forces to passively control the movement of liquid samples within a microfluidic device. To detect a target, a liquid sample introduced to a proximal portion of a capillary channel of a microfluidic device moves by capillary action along the specific components of capillary channel.Type: ApplicationFiled: March 17, 2017Publication date: April 25, 2019Applicant: Quidel Cardiovascular Inc.Inventors: Erik Mikael OLSSON, Austin DERFUS, Armando TOVAR, Justin DAVIDSON, Tuan DO, Paul CRIVELLI, Matthew WANG
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Publication number: 20170152081Abstract: A liquid storage and delivery mechanism and method of use are provided. The mechanism comprises shells that include corresponding reservoirs to hold individual quantities of liquid. The shells include filling ends and discharge ends. The filling ends include fill ports that open to the reservoirs in order to receive the corresponding quantity of liquid. The discharge ends are covered with closure lids to seal bottoms of the corresponding reservoirs. A shell management module is provided comprising a cover and a platform. The platform includes shell retention chambers to receive corresponding shells. The shell retention chambers are arranged in a predetermined pattern on the platform. The shell retention chambers are to orient shells with the fill ports exposed from the platform. The cover is mounted onto the platform to close the fill ports. The shells are to move individually, along the shell retention chambers, between non-actuated and actuated positions.Type: ApplicationFiled: November 30, 2016Publication date: June 1, 2017Applicant: Illumina WayInventors: Paul Crivelli, Gary Watts
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Patent number: D639976Type: GrantFiled: June 3, 2010Date of Patent: June 14, 2011Assignee: Alere San Diego, Inc.Inventors: Karl Francis, Paul Crivelli, Emily Parker
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Patent number: D640389Type: GrantFiled: June 3, 2010Date of Patent: June 21, 2011Assignee: Alere San Diego, Inc.Inventors: Karl Francis, Paul Crivelli, Emily Parker
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Patent number: D843009Type: GrantFiled: October 14, 2016Date of Patent: March 12, 2019Assignee: Illumina, Inc.Inventors: Gary Watts, Paul Crivelli, Anna Quackenbush