Abstract: An orthopedic implant can be used for fixation of a joint or fracture and can include a tapered member and at least one fixation member. The tapered member can be configured for placement in association with one or more bone segments. The tapered member can have a longitudinally extending body that defines an upper surface portion, an opposed lower surface portion and first and second sides, where at least the first and second sides can be formed of porous metal and can have a porous metal outer surface. The at least one fixation member can be integrally formed with the tapered member and can extend laterally outwardly from the tapered member body. The at least one fixation member can be configured to secure the implant to the one or more bone segments to provide fixation of the one or more bone segments relative to the tapered member.

Abstract: An orthopedic implant can be used for fixation of a joint or fracture and can include a tapered member and at least one fixation member. The tapered member can be configured for placement in association with one or more bone segments. The tapered member can have a longitudinally extending body that defines an upper surface portion, an opposed lower surface portion and first and second sides, where at least the first and second sides can be formed of porous metal and can have a porous metal outer surface. The at least one fixation member can be integrally formed with the tapered member and can extend laterally outwardly from the tapered member body. The at least one fixation member can be configured to secure the implant to the one or more bone segments to provide fixation of the one or more bone segments relative to the tapered member.

Abstract: An orthopedic implant can be used for fixation of a joint or fracture and can include a tapered member and at least one fixation member. The tapered member can be configured for placement in association with one or more bone segments. The tapered member can have a longitudinally extending body that defines an upper surface portion, an opposed lower surface portion and first and second sides, where at least the first and second sides can be formed of porous metal and can have a porous metal outer surface. The at least one fixation member can be integrally formed with the tapered member and can extend laterally outwardly from the tapered member body. The at least one fixation member can be configured to secure the implant to the one or more bone segments to provide fixation of the one or more bone segments relative to the tapered member.

Abstract: An implant can include a bridge member having an upper surface, a lower surface and opposed sides extending between the upper and lower surfaces, where at least the sides can be formed of a porous metal construct having a porous metal outer surface. First and second fixation members can be integrally connected with the bridge member and can include a body having a width greater than a corresponding width of the bridge member and a length greater than a corresponding length of the bridge member, where at least the body can be formed of the porous metal construct with the porous metal outer surface. The implant can be positioned into the bone segments such that the bridge member can fix the bone segments in a first direction perpendicular to the bridge member and the fixation members can fix the bone segments in a second direction parallel to the bridge member.

Abstract: Compositions and methods are provided for preparing and quantifying multipotential stromal cells derived from bone marrow aspirate for use in regenerative therapy and other medical treatments. A rapid, simple assay can be performed intra-operatively to quantify multipotential stromal cells in a sample for determining a dosage of multipotential stromal cells to be administered in regenerative therapeutic compositions.

Abstract: An ankle implant for implantation at a distal tibia can include a first sleeve augment, a second sleeve augment, an intramedullary (IM) implant and a connecting peg. The first sleeve augment can have a first cannulated sleeve body comprising a first inner solid metal body portion and a first outer porous metal body portion. The IM implant can have an outer augment mounting structure. The second sleeve augment can have a second cannulated sleeve body comprising a second inner solid metal body portion and a second outer porous metal body portion. The second inner solid metal body portion can include a second sleeve first mating structure. The first and second sleeve augments can be assembled onto the IM implant in a stacked orientation with the connecting peg received by both the first sleeve first mating structure and the second sleeve first mating structure in a keyed relationship.

Abstract: An orthopedic implant can be used for fixation of a joint or fracture and can include a tapered member and at least one fixation member. The tapered member can be configured for placement in association with one or more bone segments. The tapered member can have a longitudinally extending body that defines an upper surface portion, an opposed lower surface portion and first and second sides, where at least the first and second sides can be formed of porous metal and can have a porous metal outer surface. The at least one fixation member can be integrally formed with the tapered member and can extend laterally outwardly from the tapered member body. The at least one fixation member can be configured to secure the implant to the one or more bone segments to provide fixation of the one or more bone segments relative to the tapered member.

Abstract: An ankle implant for implantation at a distal tibia can include a first sleeve augment, a second sleeve augment, an intramedullary (IM) implant and a connecting peg. The first sleeve augment can have a first cannulated sleeve body comprising a first inner solid metal body portion and a first outer porous metal body portion. The IM implant can have an outer augment mounting structure. The second sleeve augment can have a second cannulated sleeve body comprising a second inner solid metal body portion and a second outer porous metal body portion. The second inner solid metal body portion can include a second sleeve first mating structure. The first and second sleeve augments can be assembled onto the IM implant in a stacked orientation with the connecting peg received by both the first sleeve first mating structure and the second sleeve first mating structure in a keyed relationship.

Abstract: An implant can include a bridge member having an upper surface, a lower surface and opposed sides extending between the upper and lower surfaces, where at least the sides can be formed of a porous metal construct having a porous metal outer surface. First and second fixation members can be integrally connected with the bridge member and can include a body having a width greater than a corresponding width of the bridge member and a length greater than a corresponding length of the bridge member, where at least the body can be formed of the porous metal construct with the porous metal outer surface. The implant can be positioned into the bone segments such that the bridge member can fix the bone segments in a first direction perpendicular to the bridge member and the fixation members can fix the bone segments in a second direction parallel to the bridge member.

Abstract: An intramedullary device comprises a tubular body extending along a center longitudinal axis. The tubular body includes a first end and a second end. The first end is configured to engage a stem of an implant.

Abstract: Composites, constructs and implants comprising a non-resorbable polymer, such as polyetheretherketone (PEEK), having structure of interconnected struts, which may be coralline. Composites may comprise a first phase comprising a ceramic; and a second phase comprising a non-resorbable polymer; wherein each of the first and second phases have an interconnected strut structure and are substantially continuous through the composite. Implants may also comprise a non-porous component containing the non-resorbable polymer that is contiguous with a surface of the core, a surface of the porous layer (if present), or both. Methods are also provided comprising infusing a porous ceramic body, having a plurality of interconnected channels, with a non-resorbable polymer.

Abstract: A system and method for the treatment of mitral valve regurgitation by reshaping the mitral valve annulus using one or more plications of annular or adjacent tissue each fixed by a retainer is described. The system includes four devices to achieve such percutaneous direct plication annuloplasty. The first is a crossing catheter having a prolapseable or curved tip. Second, a deflecting guide catheter is used to provide a means for guiding the plication device into proper position at the subvalvular region of the mitral valve annulus. Third, the plication device is then used to make plications in the subvalvular region of the mitral valve annulus. Fourth, a “C” shaped retainer with deformable ends is deployed by the plication device in order to retain the plicated tissue in the plicated form.

Abstract: A system and method for the treatment of mitral valve regurgitation by reshaping the mitral valve annulus using one or more plications of annular or adjacent tissue each fixed by a retainer is described. The system includes four devices to achieve such percutaneous direct plication annuloplasty. The first is a crossing catheter having a prolapseable or curved tip. Second, a deflecting guide catheter is used to provide a means for guiding the plication device into proper position at the subvalvular region of the mitral valve annulus. Third, the plication device is then used to make plications in the subvalvular region of the mitral valve annulus. Fourth, a “C” shaped retainer with deformable ends is deployed by the plication device in order to retain the plicated tissue in the plicated form. A transseptal approach may be used to plicate and retain tissue on the atrial side of the mitral valve to achieve a reduction in mitral valve regurgitation.

Abstract: A deflecting guide catheter for use in minimally invasive medical procedures such as the treatment of mitral valve regurgitation by reshaping the mitral valve annulus using one or more plications of annular or adjacent tissue each fixed by a retainer is described. The catheter includes an elongated tubular portion having various durometers along its length and at least one puller wire attached to an anchor band near the distal end. The deflecting guide catheter is used to provide a means for guiding a plication device or other medical instrument into a desired position within the vasculature or heart chambers of a patient.

Abstract: Bone graft compositions comprising demineralized bone matrix, calcium phosphate, collagen and bioinductive cellular solution. Methods to repair and heal defective and missing bone using the bone graft compositions are also described.

Abstract: A deflecting guide catheter for use in minimally invasive medical procedures such as the treatment of mitral valve regurgitation by reshaping the mitral valve annulus using one or more plications of annular or adjacent tissue each fixed by a retainer is described. The catheter includes an elongated tubular portion having various durometers along its length and at least one puller wire attached to an anchor band near the distal end. The deflecting guide catheter is used to provide a means for guiding a plication device or other medical instrument into a desired position within the vasculature or heart chambers of a patient.

Abstract: Formed compositions for application to a bone surface of a human or animal subject, comprising: a bone material; and a carrier comprising denatured demineralized bone, where the composition is formed into a shape suitable for administration to the bone. Methods are provided for making formed compositions for application to a bone surface of a human or animal subject comprise mixing a demineralized bone and water; heating the mixture to form a carrier; mixing the carrier with bone to form a moldable composition; and molding the moldable composition to produce a formed composition. Several apparatuses are provided in which to hydrate the formed bone composition. Methods of hydrating a formed bone composition are also provided.

Abstract: A bone graft material comprising about 50-90% quickly bioresorbable porogen particles and about 10-50% of a calcium matrix material. A bioactive substance can be included in the matrix material, the porogen particles, or both. Commercial packages containing the bone graft materials and methods for repairing bone therewith are also claimed.

Abstract: A system and method for the treatment of mitral valve regurgitation by reshaping the mitral valve annulus using one or more plications of annular or adjacent tissue each fixed by a retainer is described. The system includes four devices to achieve such percutaneous direct plication annuloplasty. The first is a crossing catheter having a prolapseable or curved tip. Second, a deflecting guide catheter is used to provide a means for guiding the plication device into proper position at the subvalvular region of the mitral valve annulus. Third, the plication device is then used to make plications in the subvalvular region of the mitral valve annulus. Fourth, a “C” shaped retainer with deformable ends is deployed by the plication device in order to retain the plicated tissue in the plicated form. A transseptal approach may be used to plicate and retain tissue on the atrial side of the mitral valve to achieve a reduction in mitral valve regurgitation.

Abstract: Bone graft compositions comprising demineralized bone matrix, calcium phosphate, collagen and bioinductive cellular solution. Methods to repair and heal defective and missing bone using the bone graft compositions are also described.