Patents by Inventor Paul D. Beer
Paul D. Beer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20090110634Abstract: The present invention relates to radiolabelled nanoparticles having a radioisotope non-covalently bonded thereto. The radiolabelled nanoparticles are useful as radiopharmaceuticals. Kits and methods of preparation of the radiolabelled nanoparticles are also disclosed.Type: ApplicationFiled: July 14, 2006Publication date: April 30, 2009Inventors: Paul D. Beer, Michael Lankshear, Hema Dattani, Alex Jackson, Michelle Avory
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Patent number: 6342634Abstract: Disclosed are “acid-amide” calixarenes of formula (I) wherein: L is [—CH2—] or [—O—CH2—O—] and may be the same or different between each aryl group R5 is H, halogen, or C1-C10 aliphatic hydrocarbyl group, C6-C20 aryl group, any of which may optionally be substituted by one or more halo or oxo groups or interrupted by one or more oxo groups, and R5 may be the same or different on each aryl group; R1 comprises an optionally protected carboxy group; two groups out of R2, R3, and R4, are H; the one group out of R2, R3, and R4 not being H comprises an amide group. The amide group may be linked to a second calixarene to form a dimer. Also disclosed are methods of use of such calixarenes for the purposes of metal sequestration, especially of lanthanides and actinides. Also disclosed are calixarene dimer derivatives of the calixarenes of the invention.Type: GrantFiled: June 14, 2001Date of Patent: January 29, 2002Assignee: The Secretary of State for Defence in Her Brittanic Majesty's Government of the United Kingdom of Great Britain and Northern IrelandInventors: Graeme P. Nicholson, Mark J. Kan, Gareth Williams, Michael G. Drew, Paul D. Beer
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Publication number: 20020002290Abstract: 1Type: ApplicationFiled: June 14, 2001Publication date: January 3, 2002Applicant: Secretary of State for Defence in her Britannic Majesty's Government of the United KingdomInventors: Graeme P. Nicholson, Mark J. Kan, Gareth Williams, Michael G. Drew, Paul D. Beer
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Patent number: 6326394Abstract: A cyclic compound of formula (I) wherein Rx groups which may be the same or different are selected from —O—(CH2)n—O— where n is an integer of from 2-6; Ry and Rz groups which may be the same or different are independently selected from hydrogen, halogen or a hydrocarbyl group; Ra together with Rb of the adjacent phenyl ring and Rc together with Rd of the adjacent phenyl ring form a group of formula —(CH2)m— or —(CH2)p—O— where m and p are integers of from 1-5, and each group Ra-Rb and Rc-Rd may be the same or different; and x is an integer of 2 or more, such as 4. Compounds of formula (I) display particular selectivity for specific ions such as potassium ions. They are useful inter alia in reactions where scavenging of a specific cation is required or as ion specific electrodes.Type: GrantFiled: June 30, 2000Date of Patent: December 4, 2001Assignee: The Secretary of State for Defence in Her Britannic Majesty's Government of the United Kingdom of Great Britain and Northern IrelandInventors: Philippe Schmitt, Paul D Beer
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Patent number: 6297395Abstract: Disclosed are “acid-amide” calixarenes of formula (I) wherein: L is [—CH2—] or [—O—CH2—O—] and may be the same or different between each aryl group; R5 is H, halogen, or C1-C10 aliphatic hydrocarbyl group, C6-C20 aryl group, C6-C10 hydrocarbyaryl group, any of which may optionally be substituted by one or more halo or oxo groups or interrupted by one or more oxo groups, and R5 may be the same or different on each aryl group; R1 comprises an optionally protected carboxy group; two groups out of R2, R3, and R4 are H; the one group out of R2, R3, and R4 not being H comprises an amide group. The amide group may be linked to a second calixarene to form a dimer. Also disclosed are methods of use of such calixarenes for the purposes of metal sequestration, especially of lanthanides and actinides. Also disclosed are calixarene dimer derivatives of the calixarenes of the invention. Also disclosed are processes for preparing the calixarenes and dimers.Type: GrantFiled: December 13, 1999Date of Patent: October 2, 2001Assignee: The Secretary of State for Defence in Her Brittanic Majesty's Government of the United Kingdom of Great Britain and Northern IrelandInventors: Graeme P. Nicholson, Mark J. Kan, Gareth Williams, Michael G. Drew, Paul D. Beer
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Patent number: 5874584Abstract: An ion-sensitive calix(4)arene compound having the formula A.sup.2 +B.sup.2 - wherein A represents a cation capable of forming a receptor-substrate complex with an anion, and B represents sulfate, nitrate or borate, characterized in that the cation is an anion receptor represented by the formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are each independently a substituted or unsubstituted alkyl group or a substituted or unsubstituted aryl group wherein substituents are selected from alkyl C(O)NH--, aryl C(O)NH--, alkoxy, aryloxy, alkoxycarbonyl, aryloxycarbonyl, alkylsulfonamido, arylsulfonamido, alkylcarbonyl, alkoxycarbonyl, aryloxycarbonyl, cyano and nitro;R.sup.5 and R.sup.6 are each independently H or a lower alkyl group having from 1 to 4 carbon atoms, or R.sup.3 and R.sup.4 taken together represent an ethylene bridging group; and,n is 0 or 1.Type: GrantFiled: November 5, 1997Date of Patent: February 23, 1999Assignee: Eastman Kodak CompanyInventors: Trevor John Wear, Christopher Peter Moore, Alistair J. Goulden, Paul D. Beer, Nicholas C. Fletcher
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Patent number: 5760231Abstract: An ion-sensitive calix(4)arene compound having the formula A.sup.2 +B.sup.2- wherein A represents a cation capable of forming a receptor-substrate complex with an anion, and B represents sulfate, nitrate or borate, characterized in that the cation is an anion receptor represented by the formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are each independently a substituted or unsubstituted alkyl group or a substituted or unsubstituted aryl group wherein substituents are selected from alkyl C(O)NH--, aryl C(O)NH--, alkoxy, aryloxy, alkoxycarbonyl, aryloxycarbonyl, alkylsulfonamido, arylsulfonamido, alkylcarbonyl, alkoxycarbonyl, aryloxycarbonyl, cyano and nitro;R.sup.5 and R.sup.6 are each independently H or a lower alkyl group having from 1 to 4 carbon atoms, or R.sup.3 and R.sup.4 taken together represent an ethylene bridging group; and,n is 0 or 1.Type: GrantFiled: October 22, 1996Date of Patent: June 2, 1998Assignee: Eastman Kodak CompanyInventors: Trevor John Wear, Christopher Peter Moore, Alistair J. Goulden, Paul D. Beer, Nicholas C. Fletcher
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Patent number: 5608059Abstract: Ion-sensitive compounds have the formula A.sup.2+ B.sup.2- wherein A represents a cation capable of forming a receptor-substrate complex with an anion, and B represents one or more counter anions, the cation being an anion receptor of the formula ##STR1## wherein R.sup.1 and R.sup.2 are each independently a substituted or unsubstituted alkyl group, a substituted or unsubstituted aryl group or R.sup.1 and R.sup.2 taken together with the atoms separating them represent the atoms necessary to complete a (2)-cryptand; and,R.sup.3 and R.sup.4 are each independently H or a lower alkyl group having from 1 to 4 carbon atoms, or R.sup.3 and R.sup.4 taken together represent an ethylene bridging group.The compounds may be used for sensing anions.Type: GrantFiled: December 19, 1994Date of Patent: March 4, 1997Assignee: Eastman Kodak CompanyInventors: Trevor J. Wear, Christopher P. Moore, Alistair J. Goulden, Paul D. Beer, Nicholas C. Fletcher
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Patent number: 5550268Abstract: An ion sensitive compound has the formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are each independently hydrogen, a substituted or unsubstituted alkyl group, a substituted or unsubstituted aryl group, an alkylamido group, an arylamido group, an alkylsulfonamido group, an arylsulfonamido group or a nitro group;R.sup.5 and R.sup.6 are each independently a substituted or unsubstituted alkylene group;X is Fe or Co.sup.+ ;Y is a counter anion; and,n is 0 or 1.Such compounds can be used for sensing anions.Type: GrantFiled: August 21, 1995Date of Patent: August 27, 1996Assignee: Eastman Kodak CompanyInventors: Christopher P. Moore, Trevor J. Wear, Paul D. Beer, Alistair J. Goulden
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Patent number: 5541330Abstract: Ion-sensitive compounds are provided comprising a quaternary polypyridinium receptor designed to bind anionic species by the formation of a receptor-substrate complex. The receptor comprises one or more quaternary 2,2'-bipyridyl moieties. The compounds are of use in applications requiring anion detection or removal.Type: GrantFiled: May 12, 1995Date of Patent: July 30, 1996Assignee: Eastman Kodak CompanyInventors: Trevor J. Wear, Christopher P. Moore, Paul D. Beer, John W. Wheeler
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Patent number: 5144052Abstract: A class of ligands capable of solution recognition of anions is defined by a cobalticinium moiety and an adjacent --CO--NH-amide linkage. This class is formed of redox responsive anion receptors, wherein the cobalticinium moiety is acyclic or macrocyclic.Type: GrantFiled: August 30, 1991Date of Patent: September 1, 1992Assignee: Metre International, Inc.Inventors: Paul D. Beer, Jana Hodacova, Sally Stokes
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Patent number: 5021592Abstract: A polymetallocene macrocycle which comprises a ring of alternating in-chain aromatic residues and in-chain alkylene units and which bears four or more transition metal complexes or metallocenyl groups. Such macrocycles are redox-active hydrophobic host molecules potentially useful as electron transfer mediators, for chemical sensor design, as redox catalysts or as Second Harmonic Generator material.Type: GrantFiled: April 26, 1989Date of Patent: June 4, 1991Assignee: Imperial Chemical Industries PLCInventors: Paul D. Beer, Elizabeth L. Tite
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Patent number: 5021599Abstract: A family of ligands contains the (C.sub.5 H.sub.4).sub.2 M.sup.+ moiety as a part of macrocyclic host structure capable of binding an anionic guest, wherein M is a metal ion having at least two valence states, and the host is capable of complexing with a larger fraction of the guest when M is in one of the valence states as compared to the other, for removing the guest anion from solution.Type: GrantFiled: August 31, 1989Date of Patent: June 4, 1991Assignee: Serpentix Conveyor CorporationInventors: Paul D. Beer, Anthony D. Keefe