Patents by Inventor Paul D. Hartung
Paul D. Hartung has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20200138351Abstract: A method is provided for ophthalmic measurements, wherein the amount of a fluorophore is detected in ocular tissue and the obtained fluorescence signals are normalized by performing a ratio.Type: ApplicationFiled: June 3, 2019Publication date: May 7, 2020Inventors: Charles Kerbage, Paul D. Hartung
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Patent number: 10350309Abstract: The present invention relates to a process for preparing an ointment comprising subjecting a mixture of a fluorescent molecular rotor compound, mineral oil, and grinding media to ball milling agitation and combining this mixture with a hydrophobic vehicle for an ointment. The invention also relates to an ophthalmic formulation comprising a pharmaceutically acceptable carrier and a compound of the following structural Formula (I), or a pharmaceutically acceptable salt thereof: Values and preferred values of the variables in structural Formula (I) are described herein.Type: GrantFiled: January 8, 2018Date of Patent: July 16, 2019Assignee: Cognoptix, Inc.Inventors: Haresh Bhagat, Gerald D. Cagle, Francis X. Smith, Paul D. Hartung
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Publication number: 20180126008Abstract: The present invention relates to a process for preparing an ointment comprising subjecting a mixture of a fluorescent molecular rotor compound, mineral oil, and grinding media to ball milling agitation and combining this mixture with a hydrophobic vehicle for an ointment. The invention also relates to an ophthalmic formulation comprising a pharmaceutically acceptable carrier and a compound of the following structural Formula (I), or a pharmaceutically acceptable salt thereof: Values and preferred values of the variables in structural Formula (I) are described herein.Type: ApplicationFiled: January 8, 2018Publication date: May 10, 2018Inventors: Haresh Bhagat, Gerald D. Cagle, Francis X. Smith, Paul D. Hartung
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Publication number: 20160278677Abstract: A method is provided for ophthalmic measurements, wherein the amount of a fluorophore is detected in ocular tissue and the obtained fluorescence signals are normalized by per-forming a ratio.Type: ApplicationFiled: November 12, 2013Publication date: September 29, 2016Inventors: Charles Kerbage, Paul D. Hartung
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Patent number: 9451909Abstract: In accordance with an embodiment of the invention, there is provided a device and method for detecting an amyloid protein in an eye of a mammal. A method comprises illuminating the eye with a light source having at least one of a wavelength property, a polarization property or a combination thereof, each appropriate to produce fluorescence in at least an amyloid-binding compound when the amyloid-binding compound is bound to the amyloid protein, the amyloid-binding compound having been introduced to the eye and specifically binding to the amyloid protein indicative of the amyloidogenic disorder; and determining a time decay rate of fluorescence for at least the fluorescence produced by the amyloid-binding compound bound to the amyloid protein, the determining permitting distinguishing of the presence of the amyloid-binding compound bound to the amyloid protein in the eye based on at least the time decay rate.Type: GrantFiled: December 1, 2015Date of Patent: September 27, 2016Assignee: Cognoptix, Inc.Inventors: Paul D. Hartung, Vincent Valvo, Charles Kerbage, Gerald D. Cagle, Dennis J. Nilan
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Publication number: 20160183859Abstract: In accordance with an embodiment of the invention, there is provided a device and method for detecting an amyloid protein in an eye of a mammal. A method comprises illuminating the eye with a light source having at least one of a wavelength property, a polarization property or a combination thereof, each appropriate to produce fluorescence in at least an amyloid-binding compound when the amyloid-binding compound is bound to the amyloid protein, the amyloid-binding compound having been introduced to the eye and specifically binding to the amyloid protein indicative of the amyloidogenic disorder; and determining a time decay rate of fluorescence for at least the fluorescence produced by the amyloid-binding compound bound to the amyloid protein, the determining permitting distinguishing of the presence of the amyloid-binding compound bound to the amyloid protein in the eye based on at least the time decay rate.Type: ApplicationFiled: December 1, 2015Publication date: June 30, 2016Inventors: Paul D. Hartung, Vincent Valvo, Charles Kerbage, Gerald D. Cagle, Dennis J. Nilan
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Patent number: 9220403Abstract: In accordance with an embodiment of the invention, there is provided a device and method for detecting an amyloid protein in an eye of a mammal. A method comprises illuminating the eye with a light source having at least one of a wavelength property, a polarization property or a combination thereof, each appropriate to produce fluorescence in at least an amyloid-binding compound when the amyloid-binding compound is bound to the amyloid protein, the amyloid-binding compound having been introduced to the eye and specifically binding to the amyloid protein indicative of the amyloidogenic disorder; and determining a time decay rate of fluorescence for at least the fluorescence produced by the amyloid-binding compound bound to the amyloid protein, the determining permitting distinguishing of the presence of the amyloid-binding compound bound to the amyloid protein in the eye based on at least the time decay rate.Type: GrantFiled: August 12, 2011Date of Patent: December 29, 2015Assignee: Cognoptix, Inc.Inventors: Paul D. Hartung, Vincent Valvo, Charles Kerbage, Gerald D. Cagle, Dennis J. Nilan
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Publication number: 20150118163Abstract: The present invention relates to a process for preparing an ointment comprising subjecting a mixture of a fluorescent molecular rotor compound, mineral oil, and grinding media to ball milling agitation and combining this mixture with a hydrophobic vehicle for an ointment. The invention also relates to an ophthalmic formulation comprising a pharmaceutically acceptable carrier and a compound of the following structural Formula (I), or a pharmaceutically acceptable salt thereof: Values and preferred values of the variables in structural Formula (I) are described herein.Type: ApplicationFiled: October 30, 2014Publication date: April 30, 2015Inventors: Haresh Bhagat, Gerald D. Cagle, Francis X. Smith, Paul D. Hartung
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Patent number: 8955969Abstract: A system for performing at least one of quasi-elastic light scattering and fluorescent ligand scanning on a subject's eye includes a light source configured to transmit light toward the subject's eye, a lens configured to focus light sent from the source and received from the subject's eye, a measurement reflector disposed to receive at least a portion of the focused light and configured to reflect a first portion of the received light, a camera configured and disposed to receive the first portion of the received light and configured to provide indicia of an image corresponding to the first portion of the received light, and a processor coupled to the camera and configured to analyze intensities of light in the image to determine a location of a reference point corresponding to an interface of a portion of the eye.Type: GrantFiled: March 27, 2009Date of Patent: February 17, 2015Assignee: Cognoptix, Inc.Inventors: Paul D. Hartung, Vincent Valvo, Dennis J. Nilan
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Publication number: 20130135580Abstract: In accordance with an embodiment of the invention, there is provided a device and method for detecting an amyloid protein in an eye of a mammal. A method comprises illuminating the eye with a light source having at least one of a wavelength property, a polarization property or a combination thereof, each appropriate to produce fluorescence in at least an amyloid-binding compound when the amyloid-binding compound is bound to the amyloid protein, the amyloid-binding compound having been introduced to the eye and specifically binding to the amyloid protein indicative of the amyloidogenic disorder; and determining a time decay rate of fluorescence for at least the fluorescence produced by the amyloid-binding compound bound to the amyloid protein, the determining permitting distinguishing of the presence of the amyloid-binding compound bound to the amyloid protein in the eye based on at least the time decay rate.Type: ApplicationFiled: August 12, 2011Publication date: May 30, 2013Inventors: Paul D. Hartung, Vincent Valvo, Charles Kerbage, Gerald D. Cagle, Dennis J. Nilan
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Patent number: 8388134Abstract: A system for performing quasi-elastic light scattering and fluorescent ligand scanning on a subject's eye includes a light source configured to transmit light toward the subject's eye, a lens configured to focus light sent from the source and scattered by the subject's eye, a measurement reflector disposed to receive at least a portion of the focused light and configured to reflect a first portion of the received light, a camera configured and disposed to receive the first portion of the received light and configured to provide indicia of an image corresponding to the first portion of the received light, and a processor coupled to the camera and configured to analyze intensities of light in the image to determine a location of a reference point corresponding to an interface of a portion of the eye.Type: GrantFiled: October 4, 2010Date of Patent: March 5, 2013Assignee: Cognoptix, Inc.Inventors: Lee E. Goldstein, Norman C. Ford, Leo T. Chylack, Jr., Paul D. Hartung, Marc D. Friedman, Evan A. Sherr, Stephen D. Fantone
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Publication number: 20110116041Abstract: A system for performing at least one of quasi-elastic light scattering and fluorescent ligand scanning on a subject's eye includes a light source configured to transmit light toward the subject's eye, a lens configured to focus light sent from the source and received from the subject's eye, a measurement reflector disposed to receive at least a portion of the focused light and configured to reflect a first portion of the received light, a camera configured and disposed to receive the first portion of the received light and configured to provide indicia of an image corresponding to the first portion of the received light, and a processor coupled to the camera and configured to analyze intensities of light in the image to determine a location of a reference point corresponding to an interface of a portion of the eye.Type: ApplicationFiled: March 27, 2009Publication date: May 19, 2011Inventors: Paul D. Hartung, Vincent Valvo, Dennis J. Nilan
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Publication number: 20110080559Abstract: A system for performing quasi-elastic light scattering and fluorescent ligand scanning on a subject's eye includes a light source configured to transmit light toward the subject's eye, a lens configured to focus light sent from the source and scattered by the subject's eye, a measurement reflector disposed to receive at least a portion of the focused light and configured to reflect a first portion of the received light, a camera configured and disposed to receive the first portion of the received light and configured to provide indicia of an image corresponding to the first portion of the received light, and a processor coupled to the camera and configured to analyze intensities of light in the image to determine a location of a reference point corresponding to an interface of a portion of the eye.Type: ApplicationFiled: October 4, 2010Publication date: April 7, 2011Inventors: Lee E. Goldstein, Norman C. Ford, Leo T. Chylack, JR., Paul D. Hartung, Marc D. Friedman, Evan A. Sherr, Stephen D. Fantone
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Patent number: 7828436Abstract: A system for performing quasi-elastic light scattering and fluorescent ligand scanning on a subject's eye includes a light source configured to transmit light toward the subject's eye, a lens configured to focus light sent from the source and scattered by the subject's eye, a measurement reflector disposed to receive at least a portion of the focused light and configured to reflect a first portion of the received light, a camera configured and disposed to receive the first portion of the received light and configured to provide indicia of an image corresponding to the first portion of the received light, and a processor coupled to the camera and configured to analyze intensities of light in the image to determine a location of a reference point corresponding to an interface of a portion of the eye.Type: GrantFiled: April 11, 2007Date of Patent: November 9, 2010Assignee: Neuroptix CorporationInventors: Lee E. Goldstein, Norman C. Ford, Leo T. Chylack, Jr., Paul D. Hartung, Marc D. Friedman, Evan A. Sherr, Stephen D. Fantone
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Publication number: 20090041666Abstract: The invention provides ophthalmic formulations of Amyloid-? contrast agents. Also provided are methods of using such formulations in the diagnosis of Alzheimer's Disease or a predisposition thereto as well as methods for the prognosis of Alzheimer's Disease.Type: ApplicationFiled: May 21, 2008Publication date: February 12, 2009Inventors: Lee E. Goldstein, Evan A. Sherr, Paul D. Hartung, Francis X. Smith, Kevin R. Sullivan