Patents by Inventor Paul D. Schuman
Paul D. Schuman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5951920Abstract: A process for preparing optical fiber cladding solutions starting with a monomer having the formulaCH.sub.2 .dbd.C(R)COOCHXYwhereR is H or methyl;X is H or CF.sub.3,Y is H or CF.sub.3 provided that when X is H, Y is --CF.sub.3, --CF(CF.sub.3)OCF.sub.2 CF(CF.sub.3)OC.sub.4 F.sub.9 or --(CF.sub.2).sub.n Z,Z is F or H; andn is 1 to 8.The monomers are subjected to UV light at about 1-400 nm for one to four hours until a cladding solution of desired viscosity is obtained.Type: GrantFiled: June 20, 1997Date of Patent: September 14, 1999Assignee: Optical Polymer Research, Inc.Inventors: Paul D. Schuman, Raja Mani, Patrick Kelly
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Patent number: 5690863Abstract: Curable optical fiber cladding compositions that exhibit improved optical, mechanical, adhesive and moisture barrier properties are prepared from a 100% reactive composition of monofunctional and multi-functional monomers. The preferred components of these compositions are low molecular weight polymers of fluorine-containing monofunctional acrylate or methacrylate monomer(s), such polymers being soluble and dissolved in a fluorocarbon acrylate or methacrylate monomer or monomers, but not necessarily those of the base polymer. The preferred cladding compositions may be prepared with or without a cross-linking monomer such as a di-functional or poly-functional acrylate of methacrylate. The claddings may also use a thermal or photoinitiator or other known polymerization initiating system and an adhesion promoter or promoters, such as acrylic or methacrylic acid, a silanol acrylate, methacrylate, alkoxysilane acrylate or methacrylate, or an alkoxy vinyl silane, aryl acrylate or methacrylate.Type: GrantFiled: May 10, 1996Date of Patent: November 25, 1997Assignee: Optical Polymer Research, Inc.Inventor: Paul D. Schuman
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Patent number: 4408048Abstract: A process for preparing 5-fluorouracil, and a novel starting compound for such process, are disclosed. The novel starting compound is 2,4,5-trifluoropyrimidine. The process comprises hydrolyzing the 2,4,5-trifluoropyrimidine at a temperature of about 2.degree. to about 100.degree. C., thereby directly producing the compound 5-fluorouracil.5-Fluorouracil is a known anti-tumor agent, which has been used in the treatment of various types of cancers. In addition, 5-fluorouracil is a starting material for the production of certain types of pro-drugs, which are metabolized to form 5-fluorouracil in the body, such as, for instance, the compound 1-(2-tetrahydrofuryl)-5-fluorouracil.Type: GrantFiled: May 18, 1981Date of Patent: October 4, 1983Assignee: PCR IncorporatedInventors: Ralph J. DePasquale, Paul D. Schuman
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Patent number: 4299961Abstract: A process for preparing 5-fluorouracil, and a novel starting compound for such process, are disclosed. The novel starting compound is 2,4,5-trifluoropyrimidine. The process comprises hydrolyzing the 2,4,5-trifluoropyrimidine at a temperature of about 2.degree. to about 100.degree. C., thereby directly producing the compound 5-fluorouracil.5-fluorouracil is a known anti-tumor agent, which has been used in the treatment of various types of cancers. In addition, 5-fluorouracil is a starting material for the production of certain types of pro-drugs, which are metabolized to form 5-fluorouracil in the body, such as, for instance, the compound 1-(2-tetrahydrofuryl)-5-fluorouracil.Type: GrantFiled: January 7, 1980Date of Patent: November 10, 1981Assignee: PCR, IncorporatedInventors: Ralph J. De Pasquale, Paul D. Schuman
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Patent number: 4246411Abstract: Direct fluorination of uracil, cytosine and their derivatives, in the presence of a non-aqueous solvent, by fluorine gas to produce 5-fluorouracil, 5-fluorocytosine, 5-fluorouracil derivatives and 5-fluorocytosine derivatives is disclosed. The non-aqueous solvent is an acid or alcohol, which can be partly or fully fluorinated or chlorinated, of up to 8 carbon atoms, such as trifluoroacetic acid. Novel compounds produced by the reaction, such as 5,5-difluoro-5,6-dihydro-6-(2,2,2-trifluoroethoxy) uracil are also disclosed. The derivatives and 5-fluorocytosine are useful as germicidal and antineoplastic agents while 5-fluorouracil itself is a known cancer chemotherapy agent.Type: GrantFiled: March 14, 1977Date of Patent: January 20, 1981Assignee: PCR IncorporatedInventors: Paul D. Schuman, Geraldine Westmoreland, Roy Anderson
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Patent number: 4113949Abstract: Direct fluorination of uracil and its derivatives, in the presence of an aqueous solvent, by fluorine gas to produce 5-fluorouracil and 5-fluorouracil derivatives is disclosed. Novel compounds produced by the reaction, such as 5,5-difluoro-6-hydroxy-5,6-dihydrouracil are also disclosed. The derivatives of 5-fluorouracil are useful as germicidal agents while 5-fluorouracil itself is a known cancer chemotherapy agent.Type: GrantFiled: March 11, 1976Date of Patent: September 12, 1978Assignee: PCR, Inc.Inventors: Paul D. Schuman, Paul Tarrant, Dale A. Warner, Geraldine Westmoreland
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Patent number: 4029661Abstract: Direct fluorination of uracil, cytosine and their derivatives, in the presence of a non-aqueous solvent, by fluorine gas to produce 5-fluorouracil, 5-fluorocytosine, 5-fluorouracil derivatives and 5-fluorocytosine derivatives is disclosed. The non-aqueous solvent is an acid or alcohol, which can be partly or fully fluorinated or chlorinated, of up to 8 carbon atoms, such as trifluoroacetic acid. Novel compounds produced by the reaction, such as 5,5-difluoro-5,6-dihydro-6-(2,2,2-trifluoroethoxy) uracil are also disclosed. The derivatives and 5-fluorocytosine are useful as germicidal and antineoplastic agents while 5-fluorouracil itself is a known cancer chemotherapy agent.Type: GrantFiled: July 13, 1972Date of Patent: June 14, 1977Assignee: PCR, Inc.Inventors: Paul D. Schuman, Geraldine Westmoreland, Roy Anderson
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Patent number: 4024143Abstract: A process for producing bis-silyl derivatives of fluorinated pyrimidines is disclosed, wherein a 5-fluoro-6-hydroxy or alkoxy pyrimidine is reacted with a silane, such as triethylchlorosilane. The intermediate product produced by that reaction, which is obtained in high yield, may then be reacted with a further compound, which can be a blocked sugar halide or 2-chlorotetrahydrofuran, to produce a nucleoside of the pyrimidine. The nucleosides are useful as antibacterial and antiviral agents, and in the treatment of cancer.Type: GrantFiled: March 11, 1976Date of Patent: May 17, 1977Assignee: PCR, Inc.Inventors: Paul D. Schuman, Roy Anderson
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Patent number: 3954759Abstract: The reaction of certain fluorinated pyrimidine derivatives with hydrogen donor compounds to produce 6-substituted 5-fluoropyrimidines is disclosed. The products so produced are useful in germicidal and antineoplastic applications, and can be converted into 5-fluorouracil, which has known utility in cancer chemotherapy.Type: GrantFiled: July 13, 1972Date of Patent: May 4, 1976Assignee: PCR, Inc.Inventors: Roy Anderson, Paul D. Schuman
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Patent number: 3954758Abstract: Direct fluorination of uracil and its derivatives, in the presence of an aqueous solvent, by fluorine gas to produce 5-fluorouracil and 5-fluorouracil derivatives is disclosed. Novel compounds produced by the reaction, such as 5,5-difluoro-6-hydroxy-5,6-dihydrouracil are also disclosed. The derivatives of 5-fluorouracil are useful as germicidal agents while 5-fluorouracil itself is a known cancer chemotherapy agent.Type: GrantFiled: October 4, 1971Date of Patent: May 4, 1976Assignee: PCR, Inc.Inventors: Paul D. Schuman, Paul Tarrant, Dale A. Warner, Geraldine Westmoreland