Patents by Inventor Paul D. Sleezer

Paul D. Sleezer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Purification of ceforanide
    Patent number: 4448958
    Abstract: Crude cephalosporin 7-[.alpha.-(2-aminomethylphenyl)acetamido]-3-[(1-carboxymethyltetrazol-5-y lthio)methyl]-3-cephem-4-carboxylic acid is purified by converting it to its salt with benzyldimethylamine, recovering said salt and from it regenerating said cephalosporin in purified form.
    Type: Grant
    Filed: October 20, 1982
    Date of Patent: May 15, 1984
    Assignee: Bristol-Myers Company
    Inventors: Paul D. Sleezer, Richard R. Smith
  • Esterification process using methoxymethyl-P-toluenesulfonate
    Patent number: 4247461
    Abstract: A new esterifying agent, i.e. methoxymethyl tosylate, is provided for use in preparing methoxymethyl esters of organic carboxylic acids. The new esterifying agent is found to be particularly advantageous in the esterification of penicillin 3-carboxyl groups or cephalosporin 4-carboxyl groups to the methoxymethyl ester group.
    Type: Grant
    Filed: November 16, 1979
    Date of Patent: January 27, 1981
    Assignee: Bristol-Myers Company
    Inventors: Jeng S. Lin, Paul D. Sleezer
  • Methoxymethyl p-toluenesulfonate
    Patent number: 4219495
    Abstract: A new esterifying agent, i.e. methoxymethyl tosylate, is provided for use in preparing methoxymethyl esters of organic carboxylic acids. The new esterifying agent is found to be particularly advantageous in the esterification of penicillin 3-carboxyl groups or cephalosporin 4-carboxyl groups to the methoxymethyl ester group.
    Type: Grant
    Filed: February 28, 1979
    Date of Patent: August 26, 1980
    Assignee: Bristol-Myers Company
    Inventors: Jeng S. Lin, Paul D. Sleezer
  • Methoxymethyl 6-[D-2,2-dimethyl-4-(4-hydroxyphenyl)-5-oxo-1-imidazolyl]penicillanate
    Patent number: 4185015
    Abstract: There is disclosed a process for preparing methoxymethyl 6-aminopenicillanate, its conversion to methoxymethyl amoxicillin and the use of the latter compound as an intermediate in the preparation of the methoxymethyl ester of p-hydroxyhetacillin which is the preferred product of this invention.
    Type: Grant
    Filed: October 3, 1977
    Date of Patent: January 22, 1980
    Assignee: Bristol-Myers Company
    Inventors: Paul D. Sleezer, David A. Johnson
  • Methoxymethyl D-6-(2,2-dimethyl-5-oxo-4-phenyl-1-imidazolidinyl)penicillanate
    Patent number: 3996236
    Abstract: The specification discloses a process for preparing methoxymethyl D-6-(2,2-dimethyl-5-oxo-4-phenyl-1-imidazolidinyl)penicillanate and the use of this compound as a well absorbed antibacterial agent and also as an intermediate in the preparation of other antibiotic derivatives of 6-aminopenicillanic acid such as hetacillin. The methoxymethyl ester of ampicillin is also disclosed.
    Type: Grant
    Filed: February 18, 1975
    Date of Patent: December 7, 1976
    Assignee: Bristol-Myers Company
    Inventors: Paul D. Sleezer, David A. Johnson