Abstract: An implantable cardiac defibrillator (ICD) system includes an ICD implanted subcutaneously in a patient, a defibrillation lead having a proximal portion coupled to the ICD and a distal portion having a defibrillation electrode configured to deliver a defibrillation or cardioversion shock to a heart of the patient, and a pacing lead that includes a distal portion having one or more electrodes and a proximal portion coupled to the ICD. The distal portion of the pacing lead is implanted at least partially along a posterior side of a sternum of the patient within the anterior mediastinum. The ICD is configured to provide pacing pulses to the heart of the patient via the pacing lead and provide defibrillation shocks to the patient via the defibrillation lead. As such, the implantable cardiac system provides pacing from the substernal space for an extravascular ICD system.

Abstract: A band includes a latch body that is movable by pulling a tab. The latch body extends through an opening of the band and secures with a pin located on a head-mountable device. The band can detach from the head-mountable device by pulling the tab, which actuates the latch body and removes the latch body from the pin. A spring (or springs) can bias the latch body toward the opening, causing the latch body to enter the pin. An applied force to the tab can overcome the biasing force provided by the spring(s), and move the latch body away from, and out of, the pin.

Abstract: Several gastrointestinal surgery procedures are effective as treatments for metabolic disorders such as obesity and diabetes. Minimally invasive procedures including intra-luminal gastrointestinal implants have been proposed to mimic the anatomical, physiological and metabolic changes achieved by these procedures. Many of these designs include long sleeve like elements that prevent contact of food with the walls of the small intestine. It is desirable to have simple delivery systems that can place these implants under endoscopic guidance. However, in order to anchor these sleeve elements safely and reliably, the inventors have previously disclosed anchoring means that anchor the sleeves at the junctions of the stomach and the intestine or the stomach and esophagus.

Abstract: A system comprises a memory and a processor. The memory stores information about a milking stall where a dairy livestock is located at a first time, and a coordinate location of the dairy livestock at a second time. The processor is communicatively coupled to the memory and determines if the coordinate location of the dairy livestock at the second time is different than the milking stall where the dairy livestock is located at the first time. If the coordinate location where the dairy livestock is located at the second time is not the milking stall, the processor generates an error flag associated with the dairy livestock.

Abstract: A method for estrus detection includes storing location information associated with a dairy livestock. This information includes coordinate locations of the dairy livestock within a free stall pen at each of a plurality of times during a time period including a first time and a second time. The coordinate locations comprise at least a first (X, Y, Z) location of the dairy livestock at the first time and a second (X, Y, Z) location of the dairy livestock at the second time. The method further includes determining, based on at least the first and second (X, Y, Z) locations, a turn index parameter indicating a number of times the dairy livestock reverses directions during the time period. The method further includes determining whether the dairy livestock is likely to be in estrus based at least in part upon whether the determined turn index parameter is in excess of a baseline turn index parameter by more than a first predefined amount.

Abstract: A method for health monitoring comprises electronically receiving location information for a dairy livestock that is generated by a plurality of identification devices positioned in a pen that operate in conjunction with a tag worn by the dairy livestock. The method stores the location information associated with the dairy livestock, the location information comprising a location of the dairy livestock within the pen at each of a plurality of times during a first time period. The method determines, based on at least a portion of the stored location information, a turn index parameter indicating a number of times the particular dairy livestock reverses direction during the first time period. The method determines whether the particular dairy livestock is likely to be in estrus based at least in part upon whether the determined turn index parameter is in excess of a baseline turn index parameter by more than a predefined amount.

Abstract: A system comprises a memory and a processor. The memory stores information about a milking stall where a dairy livestock is located at a first time, and a coordinate location of the dairy livestock at a second time. The processor is communicatively coupled to the memory and determines if the coordinate location of the dairy livestock at the second time is different than the milking stall where the dairy livestock is located at the first time. If the coordinate location where the dairy livestock is located at the second time is not the milking stall, the processor generates an error flag associated with the dairy livestock.

Abstract: A system comprises a memory and a processor. The memory stores information about a milking stall where a dairy livestock is located at a first time, and a coordinate location of the dairy livestock at a second time. The processor is communicatively coupled to the memory and determines if the coordinate location of the dairy livestock at the second time is different than the milking stall where the dairy livestock is located at the first time. If the coordinate location where the dairy livestock is located at the second time is not the milking stall, the processor generates an error flag associated with the dairy livestock.

Abstract: A method for estrus detection includes storing location information associated with a dairy livestock. This information includes coordinate locations of the dairy livestock within a free stall pen at each of a plurality of times during a time period including a first time and a second time. The coordinate locations comprise at least a first (X, Y, Z) location of the dairy livestock at the first time and a second (X, Y, Z) location of the dairy livestock at the second time. The method further includes determining, based on at least the first and second (X, Y, Z) locations, a turn index parameter indicating a number of times the dairy livestock reverses directions during the time period. The method further includes determining whether the dairy livestock is likely to be in estrus based at least in part upon whether the determined turn index parameter is in excess of a baseline turn index parameter by more than a first predefined amount.

Abstract: In certain embodiments, a method for estrus detection includes storing location information associated with a dairy livestock. The stored location information includes a coordinate location of the dairy livestock within a free stall pen at each of a plurality of times during a time period. The method further includes determining, based on at least a portion of the stored location information, one or more movement parameters associated with the dairy livestock. The method further includes determining, based on one or more movement parameters associated with the dairy livestock, whether the dairy livestock is likely to be in estrus.

Abstract: A system comprises a memory and a processor. The memory stores information about a milking stall where a dairy livestock is located at a first time, and a coordinate location of the dairy livestock at a second time. The processor is communicatively coupled to the memory and determines if the coordinate location of the dairy livestock at the second time is different than the milking stall where the dairy livestock is located at the first time. If the coordinate location where the dairy livestock is located at the second time is not the milking stall, the processor generates an error flag associated with the dairy livestock.

Abstract: A method for health monitoring comprises electronically receiving location information for a dairy livestock that is generated by a plurality of identification devices positioned in a pen that operate in conjunction with a tag worn by the dairy livestock. The method stores the location information associated with the dairy livestock, the location information comprising a location of the dairy livestock within the pen at each of a plurality of times during a first time period. The method determines, based on at least a portion of the stored location information, a turn index parameter indicating a number of times the particular dairy livestock reverses direction during the first time period. The method determines whether the particular dairy livestock is likely to be in estrus based at least in part upon whether the determined turn index parameter is in excess of a baseline turn index parameter by more than a predefined amount.

Abstract: In certain embodiments, a method for milking stall assignment includes storing first location information associated with a dairy livestock, the first location information comprising a coordinate location of the dairy livestock within a milking parlor at a first time. The method further includes comparing the stored first location information associated with the dairy livestock with an area associated with each of a plurality of milking stalls of the milking parlor to identify a milking stall in which the dairy cow is located at the first time and assigning the dairy livestock to the milking stall in which the dairy cow is located at the first time such that data associated with milking of the dairy livestock may be associated with the dairy cow.

Abstract: In certain embodiments, a method includes storing location information associated with a dairy livestock. The stored location information includes a location of the dairy livestock within a free stall pen at each of a plurality of times during a time period. The method further includes determining, based on at least a portion of the stored location information, one or more movement parameters associated with the dairy livestock. The method further includes determining, based on the one or more movement parameters associated with the dairy livestock, whether the dairy livestock is likely unhealthy.

Abstract: The present invention relates to the use of genetic variants of associated marker genes to predict an individual's susceptibility to muscular injury and muscular side effects in response to statin therapy. The present invention further relates to analytical assays and computational methods using the novel marker gene set. The present invention has utility for personalized medical treatment, drug safety, statin compliance, and prophylaxis of muscle side effect.

Abstract: In certain embodiments, a method for estrus detection includes storing location information associated with a dairy livestock. The stored location information includes a coordinate location of the dairy livestock within a free stall pen at each of a plurality of times during a time period. The method further includes determining, based on at least a portion of the stored location information, one or more movement parameters associated with the dairy livestock. The method further includes determining, based on one or more movement parameters associated with the dairy livestock, whether the dairy livestock is likely to be in estrus.

Abstract: In certain embodiments, a method for milking stall assignment includes storing first location information associated with a dairy livestock, the first location information comprising a coordinate location of the dairy livestock within a milking parlor at a first time. The method further includes comparing the stored first location information associated with the dairy livestock with an area associated with each of a plurality of milking stalls of the milking parlor to identify a milking stall in which the dairy cow is located at the first time and assigning the dairy livestock to the milking stall in which the dairy cow is located at the first time such that data associated with milking of the dairy livestock may be associated with the dairy cow.

Abstract: In certain embodiments, a method includes storing location information associated with a dairy livestock. The stored location information includes a location of the dairy livestock within a free stall pen at each of a plurality of times during a time period. The method further includes determining, based on at least a portion of the stored location information, one or more movement parameters associated with the dairy livestock. The method further includes determining, based on the one or more movement parameters associated with the dairy livestock, whether the dairy livestock is likely unhealthy.

Abstract: The present invention relates to the use of genetic variants of associated marker genes to predict an individual's susceptibility to muscular injury and muscular side effects in response to statin therapy. The present invention further relates to analytical assays and computational methods using the novel marker gene set. The present invention has utility for personalized medical treatment, drug safety, statin compliance, and prophylaxis of muscle side effect.

Abstract: The present invention relates to the use of genetic variants of associated marker genes to predict an individual's response to exercise. The present invention further relates to analytical assays and computational methods using the novel marker gene set. The present invention has utility for developing personalized fitness regimens to optimize physiological response.