Patents by Inventor Paul D. Weeks
Paul D. Weeks has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 4530792Abstract: A process for the preparation of 1,1-dioxopenicillanoyloxymethyl 6-beta-aminopenicillanate which comprises reacting 1,1-dioxopenicillanoyloxymethyl 6-phenylacetamidopenicillanate or the corresponding phenoxyacetamidopenicillanate under anhydrous conditions with a halogenating agent in the presence of a reaction inert solvent to form an intermediate imino halide, addition of a primary alcohol having from one to four carbon atoms to convert the imino halide to an imino ether and subsequent hydrolysis to give the desired product.Type: GrantFiled: November 1, 1982Date of Patent: July 23, 1985Assignee: Pfizer Inc.Inventor: Paul D. Weeks
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Patent number: 4483982Abstract: Processes for the preparation of the antiinflammatory agent piroxicam and intermediates leading thereto, the first of which comprises reacting N-methylsaccharin with (N-2-pyridyl)haloacetamides and alkyl haloacetates in the presence of an appropriate base to give, respectively, piroxicam and alkyl 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxides, intermediates which can be converted into piroxicam; and the second of which comprises reacting a novel alkyl 2-(2-methyl-3-hydroxy-2,3-dihydro-1,2-benzisosulfonazol-3-yl)-2-haloacetat e with a metal hydride to give alkyl 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxides, intermediates leading to piroxicam.Type: GrantFiled: April 5, 1984Date of Patent: November 20, 1984Assignee: Pfizer Inc.Inventor: Paul D. Weeks
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Patent number: 4468351Abstract: A process for the debromination of 6-monobromo- and 6,6-dibromopenicillanic acid, and various derivatives thereof, by the action of a bisulfite salt. The debrominated compounds produced find various utilities, as beta-lactamase inhibitors useful in therapy in combination with known beta-lactam antibiotics, or as intermediates in the further synthesis of useful beta-lactam compounds.Type: GrantFiled: June 6, 1983Date of Patent: August 28, 1984Assignee: Pfizer Inc.Inventors: Donald K. Pirie, Paul D. Weeks
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Patent number: 4451661Abstract: A process for preparing a compound of the formula: ##STR1## wherein R is hydrogen, lower alkyl of 1 to 6 carbon atoms, lower alkenyl of 2 to 6 carbon atoms, phenyl or benzyl; and R' is lower alkyl of 1 to 6 carbon atoms which comprises contacting a compound of the formula ##STR2## wherein R and R' are defined as above at -10.degree. to 50.degree. C. with an essentially anhydrous acid selected from the group consisting of formic acid, trifluoroacetic acid, p-toluenesulfonic acid, methanesulfonic acid, citric acid, oxalic acid, chloroacetic acid, sulfuric acid, hydrochloric acid, phosphoric acid and hydrofluoric acid.Type: GrantFiled: March 24, 1983Date of Patent: May 29, 1984Assignee: Pfizer Inc.Inventors: Paul D. Weeks, Robert P. Allingham
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Patent number: 4443621Abstract: p-Nitrophenyl 3-bromo-2,2-diethoxypropionate, useful in the synthesis of highly functionalized small molecules and heterocycles, including pyromeconic acid and 6-methylpyromeconic acid.Type: GrantFiled: March 14, 1983Date of Patent: April 17, 1984Assignee: Pfizer Inc.Inventors: John L. LaMattina, Paul D. Weeks
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Patent number: 4435584Abstract: 2-Methyl-3-hydroxy-4H-pyran-4-one is prepared by contacting 1(2-furyl)-1-ethanol in aqueous solution with two equivalents of a halogen oxidant at room temperature and then heating until the hydrolysis of the formed 4-halo-dihydropyran intermediate is substantially complete. Other valuable related gamma-pyrones are prepared in analogous manner from appropriate alcohols.Type: GrantFiled: July 19, 1982Date of Patent: March 6, 1984Assignee: Pfizer Inc.Inventors: Thomas M. Brennan, Daniel P. Brannegan, Paul D. Weeks, Donald E. Kuhla
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Patent number: 4390709Abstract: Maltol (3-hydroxy-2-methyl-gamma-pyrone) is prepared from furfural through intermediates (a) 1-(2-furyl)-1-ethanol; (b) 2-(1-hydroxyethyl)-2,5-dialkoxy-2,5-dihydrofuran; (c) alkyl or aralkyl-2-methyl-2H-pyran-3(6H)-one; and (d) 2-alkyl or aralkyl-4-methyl-3,7-dioxabicyclo[4.1.0]heptan-5-one.Pyromeconic acid (3-hydroxy-gamma-pyrone), ethyl maltol (3-hydroxy-2-ethyl-gamma-pyrone) and other valuable 2-substituted-3-hydroxy-gamma-pyrones are prepared in an analogous manner from furfural.Type: GrantFiled: April 26, 1982Date of Patent: June 28, 1983Assignee: Pfizer Inc.Inventors: Paul D. Weeks, Robert P. Allingham
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Patent number: 4387235Abstract: 2-methyl-3-hydroxy-4H-pyran-4-one is prepared by contacting 1(2-furyl)-1-ethanol in aqueous solution with two equivalents of a halogen oxidant at room temperature and then heating until the hydrolysis of the formed 4-halo-dihydropyran intermediate is substantially complete. Other valuable related gammapyrones are prepared in analogous manner from appropriate alcohols.Type: GrantFiled: October 14, 1981Date of Patent: June 7, 1983Assignee: Pfizer Inc.Inventors: Thomas M. Brennan, Daniel P. Brannegan, Paul D. Weeks, Donald E. Kuhla
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Patent number: 4376204Abstract: Processes for the preparation of the antiinflammatory agent piroxicam and intermediates leading thereto, the first of which comprises reacting N-methylsaccharin with (N-2-pyridyl)haloacetamides and alkyl haloacetates in the presence of a metal hydride to give, respectively, piroxicam and alkyl 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxides, intermediates which can be converted into piroxicam; and the second of which comprises reacting a novel alkyl 2-(2-methyl-3-hydroxy2,3-dihydro-1,2-benzisosulfonazol-3-yl)-2-haloacetate with a metal hydride to give alkyl 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxides, intermediates leading to piroxicam.Type: GrantFiled: October 5, 1981Date of Patent: March 8, 1983Assignee: Pfizer Inc.Inventor: Paul D. Weeks
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Patent number: 4368331Abstract: (2-methyl-3-hydroxy-4h-pyran-4-one is prepared by contacting 1(2-furyl)-1-ethanol in aqueous solution with two equivalents of a halogen oxidant at room temperature and then heating until the hydrolysis of the formed 4-halo-dihydro-pyran intermediate is substantially complete. Other valuable related gamma-pyrones are prepared in analogous manner from appropriate alcohols.Type: GrantFiled: November 13, 1979Date of Patent: January 11, 1983Assignee: Pfizer Inc.Inventors: Thomas M. Brennan, Daniel P. Brannegan, Donald E. Kuhla, Paul D. Weeks
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Patent number: 4342697Abstract: Maltol (3-hydroxy-2-methyl-gamma-pyrone) is prepared from furfural through intermediates (a) 1-(2-furyl)-1-ethanol; (b) 2-(1-hydroxyethyl)-2,5-dialkoxy-2,5-dihydrofuran; (c) alkyl or aralkyl-2-methyl-2H-pyran-3(6H)-one; and (d) 2-alkyl or aralkyl-4-methyl-3,7-dioxabicyclo[4.1.0]heptan-5-one.Pyromeconic acid (3-hydroxy-gamma-pyrone), ethyl maltol (3-hydroxy-2-ethyl-gamma-pyrone) and other valuable 2-substituted-3-hydroxy-gamma-pyrones are prepared in an analogous manner from furfural.Type: GrantFiled: November 11, 1976Date of Patent: August 3, 1982Assignee: Pfizer Inc.Inventors: Paul D. Weeks, Robert P. Allingham
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Patent number: 4323506Abstract: 2-Methyl-3-hydroxy-4H-pyran-4-one is prepared by contacting 1(2-furyl)-1-ethanol in aqueous solution with two equivalents of a halogen oxidant at room temperature and then heating until the hydrolysis of the formed 4-halo-dihydropyran intermediate is substantially complete. Other valuable related gammapyrones are prepared in analogous manner from appropriate alcohols.Type: GrantFiled: September 4, 1979Date of Patent: April 6, 1982Assignee: Pfizer Inc.Inventors: Thomas M. Brennan, Daniel P. Brannegan, Paul D. Weeks, Donald E. Kuhla
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Patent number: 4289704Abstract: 2-Methyl-3-hydroxy-4H-pyran-4-one is prepared by contacting 1(2-furyl)-1-ethanol in aqueous solution with two equivalents of a halogen oxidant at room temperature and then heating until the hydrolysis of the formed 4-halo-dihydropyran intermediate is substantially complete. Other valuable related gamma-pyrones are prepared in analogous manner from appropriate alcohols.Type: GrantFiled: July 2, 1980Date of Patent: September 15, 1981Assignee: Pfizer Inc.Inventors: Thomas M. Brennan, Daniel P. Brannegan, Paul D. Weeks, Donald E. Kuhla
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Patent number: 4191693Abstract: Gamma-pyrones are prepared by contacting a 3-halo-furfuryl alcohol or a 3-alkoxy-furfuryl alcohol with one equivalent of a halogen, peracid or peroxide oxidant and then heating until hydrolysis of the formed 4-substituted-dihydropyran intermediate is substantially complete. Maltol (2-methyl-3-hydroxy-4H-pyran-4-one) is prepared by this process from 2(1-hydroxyethyl)-3-alkoxy furans or 2(1-hydroxyethyl)-3-halo-furans. Gamma-pyrones are also prepared by contacting the corresponding 3-substituted-2,5-dialkoxy-furfuryl alcohols with acid until conversion to the gamma-pyrones is substantially complete.Type: GrantFiled: August 28, 1978Date of Patent: March 4, 1980Assignee: Pfizer, Inc.Inventors: Thomas M. Brennan, Daniel P. Brannegan, Paul D. Weeks, Donald E. Kuhla
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Patent number: 4173572Abstract: Gamma-pyrones are prepared by contacting a 3-halo-furfuryl alcohol or a 3-alkoxy-furfuryl alcohol with one equivalent of a halogen, peracid or peroxide oxidant and then heating until hydrolysis of the formed 4-substituted-dihydropyran intermediate is substantially complete. Maltol (2-methyl-3-hydroxy-4H-pyran-4-one) is prepared by this process from 2(1-hydroxyethyl)-3-alkoxy furans or 2(1-hydroxyethyl)-3-halo-furans. Gamma-pyrones are also prepared by contacting the corresponding 3-substituted-2,5-dialkoxy-furfuryl alcohols with acid until conversion to the gamma-pyrones is substantially complete.Type: GrantFiled: August 28, 1978Date of Patent: November 6, 1979Assignee: Pfizer Inc.Inventors: Thomas M. Brennan, Daniel P. Brannegan, Paul D. Weeks, Donald E. Kuhla
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Patent number: 4147705Abstract: 2-Methyl-3-hydroxy-4H-pyran-4-one is prepared by contacting 1(2-furyl)-1-ethanol in aqueous solution with two equivalents of a halogen oxidant at room temperature and then heating until the hydrolysis of the formed 4-halo-dihydropyran intermediate is substantially complete. Other valuable related gamma-pyrones are prepared in analogous manner from appropriate alcohols.Type: GrantFiled: January 16, 1978Date of Patent: April 3, 1979Assignee: Pfizer Inc.Inventors: Thomas M. Brennan, Daniel P. Brannegan, Paul D. Weeks, Donald E. Kuhla
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Patent number: 4126624Abstract: Gamma-pyrones are prepared by contacting a 3-halo-furfuryl alcohol or a 3-alkoxy-furfuryl alcohol with one equivalent of a halogen, peracid or peroxide oxidant and then heating until hydrolysis of the formed 4-substituted-dihydropyran intermediate is substantially complete. Maltol (2-methyl-3-hydroxy-4H-pyran-4-one) is prepared by this process from 2(1-hydroxyethyl)-3-alkoxy furans or 2(1-hydroxyethyl)-3-halo-furans. Gamma-pyrones are also prepared by contacting the corresponding 3-substituted-2,5-dialkoxy-furfuryl alcohols with acid until conversion to the gamma-pyrones is substantially complete.Type: GrantFiled: November 12, 1976Date of Patent: November 21, 1978Assignee: Pfizer Inc.Inventors: Thomas M. Brennan, Daniel P. Brannegan, Paul D. Weeks, Donald E. Kuhla
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Patent number: 4082717Abstract: 2-METHYL-3-HYDROXY-4H-pyran-4-one is prepared by contacting 1(2-furyl)-1-ethanol in aqueous solution with two equivalents of a halogen oxidant at room temperature and then heating until the hydrolysis of the formed 4-halo-dihydropyran intermediate is substantially complete. Other valuable related gamma-pyrones are prepared in analogous manner from appropriate alcohols.Type: GrantFiled: September 9, 1976Date of Patent: April 4, 1978Assignee: Pfizer Inc.Inventors: Thomas M. Brennan, Daniel P. Brannegan, Paul D. Weeks, Donald E. Kuhla
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Patent number: D1023973Type: GrantFiled: September 17, 2021Date of Patent: April 23, 2024Assignee: EATON INTELLIGENT POWER LIMITEDInventors: Paul D. Seff, Tyler D. Young, Jason D. Easton, Jeffery Kuykendall, Cory Robert Weeks