Abstract: A pump for pumping a gas, the pump comprising: a rotor and a stator; the rotor comprising at least one liquid opening configured for fluid communication with a liquid source. The liquid opening is configured such that in response to a driving force a stream of liquid is output from the opening, the stream of liquid forming a liquid blade between the rotor and the stator, gas confined by the stator, the rotor and the liquid blade being driven through the pump along a pumping channel from a gas inlet towards a gas outlet in response to relative rotational motion of the rotor and the stator. A cross sectional area of the pumping channel is configured to increase from the gas inlet to the gas outlet.

Abstract: A pump includes: a rotor and a stator; the rotor having at least one liquid opening configured for fluid communication with a liquid source. The liquid opening is configured such that a stream of liquid is output to form a liquid blade between the rotor and the stator, and gas confined by the stator, the rotor and the liquid blade is driven through the pump . The pump is configured such that a pumping channel has side walls that slope towards each other from the rotor that comprises the liquid opening towards a further wall of the pumping channel remote from the rotor, such that a distance between the side walls decreases with increasing distance from the liquid opening, a tangent to a midpoint of the side walls having an angle of between 5° and 40° with respect to a line perpendicular to an axis of rotation of the rotor.

Abstract: A vibration damping connector system to connect between a vacuum chamber and a vacuum pump such that the vacuum pump is supported by the vibration damping connector system includes a first cylindrical member and a second cylindrical member that provide a flow passage through which gas can flow from the vacuum chamber to the vacuum pump. At least one sealing member is disposed intermediate the first and second cylindrical members to provide a gas seal and a securing system securely connect the first and second cylindrical members. At least one resilient member disposed intermediate the securing system and a cylindrical member so that when the at least one sealing member is compressed by a pressure reduction caused in use by operation of the vacuum pump, the at least one resilient member can expand to enable the securing system to maintain a secure connection.

Abstract: The specification relates to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) for use in the treatment of cancer, wherein the EGFR TKI is administered in combination with a Smac mimetic.

Abstract: The specification relates to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) for use in the treatment of cancer, wherein the EGFR TKI is administered in combination with AZD2811.

Abstract: A vibration damping connector system to connect between a vacuum chamber and a vacuum pump such that the vacuum pump is supported by the vibration damping connector system includes a first cylindrical member and a second cylindrical member that provide a flow passage through which gas can flow from the vacuum chamber to the vacuum pump. At least one sealing member is disposed intermediate the first and second cylindrical members to provide a gas seal and a securing system securely connect the first and second cylindrical members. At least one resilient member disposed intermediate the securing system and a cylindrical member so that when the at least one sealing member is compressed by a pressure reduction caused in use by operation of the vacuum pump, the at least one resilient member can expand to enable the securing system to maintain a secure connection.

Abstract: A pneumatic sensing apparatus for use in an overheat or fire alarm system comprising a sensing assembly that comprises a sensing means 51, 61, 71, containing a pressurized gas, coupled to a pressure sensor 52, 62, 72. The pressure sensor 52, 62, 72, is configured to produce a signal that is indicative of the gas pressure. The pressure sensor 52, 62, 72, comprises an optical pressure sensor and the signal comprises an optical signal.

Abstract: A fire detection system for an aircraft, freight transportation vehicle or freight storage facility comprises one or more RFID tags associated with one or more items of freight being transported or stored. The RFID tag is configured to detect a condition indicative of a fire in or in the vicinity the item of freight, for example a temperature rise or generation of smoke. One or more RFID readers are arranged to read the RFID tags. The RFID reader is connected to or forms part of a control system, the RFID reader or the control determining whether the RFID tag has detected a fire.

Abstract: A fire detection system for an aircraft, freight transportation vehicle or freight storage facility comprises one or more RFID tags associated with one or more items of freight being transported or stored. The RFID tag is configured to detect a condition indicative of a fire in or in the vicinity the item of freight, for example a temperature rise or generation of smoke. One or more RFID readers are arranged to read the RFID tags. The RFID reader is connected to or forms part of a control system, the RFID reader or the control determining whether the RFID tag has detected a fire.

Abstract: A pneumatic sensing apparatus for use in an overheat or fire alarm system comprising a sensing assembly that comprises a sensing means 51, 61, 71, containing a pressurized gas, coupled to a pressure sensor 52, 62, 72. The pressure sensor 52, 62, 72, is configured to produce a signal that is indicative of the gas pressure. The pressure sensor 52, 62, 72, comprises an optical pressure sensor and the signal comprises an optical signal.

Abstract: The present invention relates to a therapeutic combination comprising a MEK inhibitor and an Aurora kinase inhibitor, and to methods for the production of an anti-cancer effect in a patient, which is accordingly useful in the treatment of cancer in a patient. More specifically the present invention relates to: a therapeutic combination comprising a MEK inhibitor and an Aurora kinase inhibitor; a combination product comprising a MEK inhibitor and an Aurora kinase inhibitor, a kit of parts comprising a MEK inhibitor and an Aurora kinase inhibitor; use of a therapeutic combination, combination product or kit of parts in the treatment of cancer; a method of treating cancer comprising administering the therapeutic combination, combination product or kit of parts to a patient. The therapeutic combination and methods of the invention are also useful in the treatment of conditions in which the inhibition of MEK and/or Aurora kinase is beneficial.

Abstract: The invention relates to a combination for use in the treatment of cancer comprising a MEK inhibitor and the Src kinase inhibitor AZD0530.

Abstract: This invention relates to a combination product, as defined herein, comprising a MEK inhibitor and a mTOR-selective inhibitor, and to methods for the production of an anti-cancer effect in a patient, which is accordingly useful in the treatment of cancer in a patient. More specifically the present invention relates to; a combination product, as defined herein, comprising a MEK inhibitor and a mTOR-selective inhibitor; a combination product, as defined herein, comprising a kit of parts comprising a MEK inhibitor and a mTOR-selective inhibitor; use of the combination product, as defined herein, in the treatment of cancer; a method of treating cancer comprising administering the combination product, as defined herein, to a patient. The combination product, as defined herein, and methods of the invention are also useful in the treatment of other diseases associated with the activity of MEK, and/or mTOR.

Abstract: Treatments for brain cancer are provided, based on administration of inhibitors of glycophospholipids synthesis.