Abstract: Provided are anti-ABCB 1 antibodies that may be used as multi-specific, including bispecific, antibodies targeting both ABCB 1 and a tumor-associated antigen (TAA), as well as pharmaceutical compositions, nucleic acids, recombinant expression vectors, cells, and kits that include or encode such antibodies and multi-specific antibodies. Further included are uses and methods of treating conditions where inhibition of ABCB 1-mediated efflux transport is desirable, such as, cancer or multi-drug resistance mediated by the ABCB1 transporter, e.g., multi-drug resistant cancer. In particular, the disclosure provides humanized multi-specific, e.g. bispecific, IgG (IgG1) antibodies that bind ABCB1 and a TAA. Multi-specific IgG1 antibody molecules are provided with Fc substitutions in at least one of a first and a second heavy chain constant region.

Abstract: A method generally includes providing calibration node information to a user system communicably coupled to the calibration management system and associated with at least the user sensor, the calibration node information identifying a calibration node of a plurality of calibration nodes communicably coupled to the calibration management system and disposed at a plurality of geographical locations; receiving, from the user system, a request to access information generated via the calibration node; causing the calibration node to perform at least one calibration action based on the request, wherein the calibration action comprises at least one of: performing an environmental measurement to measure at least one aspect of an environment at the geographical location of the calibration node, or providing a calibration reference signal to the user sensor; receiving calibration results information containing results of the calibration action; and providing information associated with the calibration results informati

Abstract: Examples relate to digital context aware (DCA) data collection. In some examples, a DCA start location component is positioned at a first location along a travel route, and a DCA end location component is positioned at a second location along the travel route. In response to using a wireless interface to detect the DCA start location component, data collection of measurements by a sensor are initiated. In response to using the wireless interface to detect the DCA end location component, the data collection by the sensor is halted.

Abstract: Techniques for building and transforming SDL representations of source code are disclosed, including: receiving, by an application programming interface (API), an API call including a symbolic description language (SDL) representation of a set of source code; determining, by the API based at least on the first API call, one or more transformations to perform on the SDL representation of the set of source code; generating, by the API, a transformed SDL representation at least by performing the one or more transformations on the SDL representation of the set of source code; supplying, by the API responsive to the first API call, the transformed SDL representation.

Abstract: Described herein is an animal kill trap. More specifically, an improved animal trap configured for trapping and humanely killing small mammalian predators. The trap comprises an integrated enclosure which utilises the lid for setting the trap mechanism, and additionally acts as a safety mechanism wherein when the lid is the open position, the trap is deactivated and thus avoiding any harm to the user. The trap comprises a tunnel architecture which is appealing to the predators, and additionally has a capture flag to indicate when a predator has been captured.

Abstract: A method and associated system for matching and delivering digital work metadata to one or more digital service providers including modifying one or more digital work metadata files, which includes removing non-critical data or segment-erroneous data or performing a language translation; reformatting the one or more digital work metadata files for compatibility with a transformer model-based AI matching operation; performing a block grouping operation on the one or more digital work metadata files, where data associated with the one or more digital work metadata files is grouped in blocks and analyzed for one or more pairs of data records; performing the transformer model-based AI matching operation to determine whether each pair of the one or more pairs of data records comprise a matching pair of data records; and transmitting output data from the transformer model-based artificial intelligence matching operation to the one or more digital service providers.

Abstract: An actuator system for height adjustment of a bicycle telescopic seat post includes a motor and a lead screw. The lead screw drives an internal pushrod, which compresses a hydraulic release button at a bottom of the seat post to cause the seat post to move up and down linearly. With a compact design, the actuator can be enclosed in a very small device and is mounted at the bottom of the seat post. The actuator is completely located within the bicycle seat tube.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for distributing resources to client devices are described. A computer-implemented system receives a request for a resource distribution constraint for a given resource of a first type, determines that a second type of resource that has a sufficient amount of historical distribution data to generate a distribution constraint, and determines the resource distribution constraint using historical distribution data for the second type of resource.

Abstract: A surgical humidification system includes a source of gas flow and a humidifier that receives the gas flow and outputs a humidified gas to a delivery conduit. The delivery conduit has an outlet and a suitable interface, such as a diffuser, is connected to the outlet. The interface can be positioned near or within an open surgical cavity of a patient to supply the humidified gas to the cavity. The system also includes a pressure relief arrangement that operates to relieve pressure from the system above a normal operating pressure. The pressure relief arrangement can be located in a non-sterile portion of the system, such as upstream from the humidifier, for example.

Abstract: The present disclosure relates to a digital electrical system for STEM construction system. In examples, the STEM construction system may consist of one or more electrical components and various structural elements to support the electrical components. The system may have a power source (e.g., battery) component with a plurality of connection pins, wherein one of the plurality of connection pins is a sensing pin used for sensing other power sources and communicating the present status of the power source component. The digital electrical system may utilize a proxy communication method where one electrical component can function as a proxy for other components in the system by collecting information on other components in the system and transmitting that to requesting components. Alternatively, a standard and coding communication methods may be used. Normalized unitless data may be communicated throughout the system.

Abstract: A dual purpose power pedestal includes a housing having a base, a body extending upwardly from the base, and a top disposed opposite the base, the body including a first side and a second side; a recreational vehicle (RV) connection mechanism disposed on the first side of the body and comprising a power receptacle and a first circuit interrupter, the RV connection mechanism being structured to be coupled to a power source and provide power to at least an RV; and an electric vehicle (EV) connection mechanism disposed on the second side of the body and comprising at least a frame, an EV connector, an EV cable, and an EV charger that is disposed within the frame and includes at least a controller and a second circuit interrupter, the EV charger being structured to charge an EV based on a signal from the controller.

Abstract: An electrical connector includes a terminal holder and a terminal positioning device. The terminal holder defines at least one terminal opening adapted to receive a terminal from a first side thereof in a terminal insertion direction. The terminal positioning device includes a sliding surface abutting a portion of the connector, and at least one terminal contact surface. The terminal positioning device is arranged adjacent the first side of the terminal holder. The device is movable relative to the terminal holder in an operating direction perpendicular to the insertion direction between a first position wherein the terminal positioning device does not overlap the at least one terminal opening in the insertion direction, and a second position wherein the at least one terminal contact surface overlaps the at least one terminal opening in the insertion direction.

Abstract: A computing system retrieves ball-by-ball data for a plurality of sporting events. The computing system generates a trained neural network based on ball-by-ball data supplemented with ball-by-ball data with ball-by-ball match context features and personalized embeddings based on a batsman and a bowler for each delivery. The computing system receives a target batsman and a target bowler for a pitch to be delivered in a target event. The computing system identifies target ball-by-ball data for a window of pitches preceding the to be delivered pitch. The computing system retrieves historical ball-by-ball data for each of the target batsman and the target bowler. The computing system generates personalized embeddings for both the target batsman and the target bowler based on the historical ball-by-ball data. The computing system predicts a shot type for the pitch to be delivered based on the target ball-by-ball data and the personalized embeddings.

Abstract: Solutions are disclosed that enable capacity-aware local repair of tunnels in packet switched wide area networks (WANs). Traffic engineering agents on the routers are programmed to create the tunnels and include sets of primary and alternate tunnels sharing the same source and destination. A tunnel source router is provided a traffic split for allocating incoming traffic to its primary and alternate tunnels for when the primary tunnel is operating at or near full capacity operation, and another traffic split that shifts at least some traffic from the primary tunnel to the alternate tunnel, when the primary tunnel's capacity drops below a threshold. A tunnel may lose capacity for commonly-occurring reasons, such as a disturbance to cabling and faults in optical transceivers. Traffic engineering agents along the tunnel report capacity to the tunnel source router, permitting the network to respond to capacity changes more rapidly than waiting for network tunnel reconfiguration.

Abstract: Techniques for lowering Java try statements in a symbolic description language are disclosed, including: obtaining a set of Java source code; determining that the set of Java source code includes a try statement; and generating, based on the set of Java source code, a symbolic description language (SDL) model including a lowered SDL representation of the try statement. The lowered SDL representation of the try statement includes: a body including a set of basic SDL blocks; an exception region including (a) a subgraph of the set of basic SDL blocks and (b) an operation covered by the exception region; and a catch entry block, in the set of basic SDL blocks, that is declared as a successor block for when the operation covered by the exception region throws an exception.

Abstract: This disclosure provides methods for treating a condition or disease associated with weight gain that include coadministration of an apelin receptor agonist and a GLP-1 receptor agonist. Methods for increasing total weight loss in the subject relative to weight loss that would be caused by administration of a pre-determined amount of a GLP-1 receptor agonist alone are also provided. In some embodiments, the method is for preserving, or maintaining muscle mass, muscle function, and/or muscle strength in a subject undergoing weight loss therapy.

Abstract: A method for demodulating an RF signal to polar in-phase and quadrature (IQ) components that includes converting an RF signal with an analog-to-digital converter and calculating the polar in-phase and quadrature (IQ) components of the RF signal as an IQ phasor phase angle and an IQ amplitude using a digital processor. The analog-to-digital converter uses a sampling rate, where, when the sampling rate used has sampling rates other than 3 times an RF carrier frequency of the RF signal, a digital logic circuit splines data to the sampling rate of 3 times the RF carrier frequency of the RF signal. The digital processor calculates the polar in-phase and quadrature (IQ) components of the RF signal as an IQ phasor phase angle and an IQ amplitude using addition, subtraction, multiplication, division, and absolute value.

Abstract: A system for calibrating a plurality of user sensors includes a calibration management system comprising a processor and a node services module and a plurality of calibration nodes disposed at a plurality of geographical locations. The processor is communicably coupled to the plurality of user sensors, the node services module, and the plurality of calibration nodes and operable to: provide calibration node information to a system associated with one of the plurality of user sensors and cause the calibration node to perform at least one calibration action after providing the calibration information, the calibration action may include performing an environmental measurement and/or providing a calibration reference signal to the user sensor. The processor is also operable to provide calibration results information containing results of the calibration action to the system associated with the one of the plurality of user sensors.

Abstract: Bi-directional tunnel probing in a network may be extended to multi-realm networks, providing bi-directional probing in a multi-realm network. Bi-directional probing uses probe packets with a forward tunnel label, a reverse tunnel label, and an IP packet header. Bi-directional probing in a multi-realm network uses a forward tunnel label, an SID, a reverse tunnel label, and an IP packet header. Penultimate hop popping strips the outermost labels in a specific order. The SID gets the probe packet back into the originating realm, and the reverse tunnel label returns the probe packet along the reverse direction of the tunnel. No SID is needed for intra-realm probing, and the IP packet header is used to return the probe packet if the reverse tunnel label is absent.