Patents by Inventor Paul Douglas Remane DYER

Paul Douglas Remane DYER has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antisense oligonucleotide compositions
    Patent number: 10400241
    Abstract: The present invention relates to antisense oligonucleotide (ASO) compositions and particularly to compositions and methods for the cytosolic delivery of antisense oligonucleotides (ASOs). Hybrid ASOs, part single-stranded and part double-stranded, are provided, hybridizing to form a double-stranded region that can non-covalently bond to nucleic-acid-binding protein regions. In this way, ASO::protein complexes may be produced that facilitate delivery of antisense DNA into target cells. Such complexes may be used to down-regulate gene expression in cells.
    Type: Grant
    Filed: February 14, 2018
    Date of Patent: September 3, 2019
    Assignee: UNIVERSITY OF GREENWICH
    Inventors: Simon Clifford Wainwright Richardson, Paul Douglas Remane Dyer, John Carlton Mitchell
  • ANTISENSE OLIGONUCLEOTIDE COMPOSITIONS
    Publication number: 20180251768
    Abstract: The present invention relates to antisense oligonucleotide (ASO) compositions and particularly to compositions and methods for the cytosolic delivery of antisense oligonucleotides (ASOs). Hybrid ASOs, part single-stranded and part double-stranded, are provided, hybridising to form a double-stranded region that can non-covalently bond to nucleic-acid-binding protein regions. In this way, ASO::protein complexes may be produced that facilitate delivery of antisense DNA into target cells. Such complexes may be used to down-regulate gene expression in cells.
    Type: Application
    Filed: February 14, 2018
    Publication date: September 6, 2018
    Applicant: UNIVERSITY OF GREENWICH
    Inventors: Simon Clifford Wainwright RICHARDSON, Paul Douglas Remane DYER, John Carlton MITCHELL
  • Antisense oligonucleotide compositions
    Patent number: 9902960
    Abstract: The present invention relates to antisense oligonucleotide (ASO) compositions and particularly to compositions and methods for the cytosolic delivery of antisense oligonucleotides (ASOs). Hybrid ASOs, part single-stranded and part double-stranded, are provided, hybridizing to form a double-stranded region that can non-covalently bond to nucleic-acid-binding protein regions. In this way, ASO::protein complexes may be produced that facilitate delivery of antisense DNA into target cells. Such complexes may be used to down-regulate gene expression in cells.
    Type: Grant
    Filed: June 23, 2014
    Date of Patent: February 27, 2018
    Assignee: UNIVERSITY OF GREENWICH
    Inventors: Simon Clifford Wainwright Richardson, Paul Douglas Remane Dyer, John Carlton Mitchell
  • ANTISENSE OLIGONUCLEOTIDE COMPOSITIONS
    Publication number: 20160152984
    Abstract: The present invention relates to antisense oligonucleotide (ASO) compositions and particularly to compositions and methods for the cytosolic delivery of antisense oligonucleotides (ASOs). Hybrid ASOs, part single-stranded and part double-stranded, are provided, hybridising to form a double-stranded region that can non-covalently bond to nucleic-acid-binding protein regions. In this way, ASO::protein complexes may be produced that facilitate delivery of antisense DNA into target cells. Such complexes may be used to down-regulate gene expression in cells.
    Type: Application
    Filed: June 23, 2014
    Publication date: June 2, 2016
    Applicant: UNIVERSITY OF GREENWICH
    Inventors: Simon Clifford Wainwright RICHARDSON, Paul Douglas Remane DYER, John Carlton MITCHELL