Abstract: A system and method for physiological assessment utilizes electrophysiological techniques, such as evoked potential (EP) data. Symptomatic and asymptomatic sensory areas are stimulated and EP data are collected. Artifacts can optionally be deleted from the raw EP data, which can then be appropriately filtered and transformed using software filtering and signal processing transformation techniques. Points of interest are detected and labeled on the resulting traces, which are output for analysis, diagnosis and treatment purposes. Differences between symptomatic and asymptomatic EPs provide objective, quantitative, repeatable information about pathological conditions.