Abstract: Disclosed herein are pyrazole pyrimidine compounds that modulate and/or inhibit hematopoietic progenitor kinase 1, as well as methods of making such compounds and therapeutic methods of using same.

Abstract: A method of operating an electrochemical cell including introducing an aqueous solution into the electrochemical cell, applying a current across an anode and a cathode to produce a product, monitoring the voltage, dissolved hydrogen, or a condition of the aqueous solution, and applying the current in a pulsed waveform responsive to one of the measured parameters is disclosed. An electrochemical system including an electrochemical cell including an anode and a cathode, a source of an aqueous solution having an outlet fluidly connectable to the electrochemical cell, a sensor for measuring a parameter, and a controller configured to cause the anode and the cathode to apply the current in a pulsed waveform responsive to the parameter measurement is disclosed. Methods of suppressing accumulation of hydrogen gas within the electrochemical cell are also disclosed. Methods of facilitating operation of an electrochemical cell are also disclosed.

Abstract: An electrochemical cell including a first chamber having an anode, a second chamber having a cathode, at least one ionic connection between the first chamber and the second chamber, such that liquid electrolyte from the first chamber is prevented from mixing with liquid electrolyte in the second chamber is provided. The first chamber and the second chamber can be arranged in parallel and positioned remotely from each other. An electrochemical system including the electrochemical cell, and first and second sources of saline aqueous solutions is also provided. Water treatment systems are also provided. A method of operating an electrochemical cell including introducing first and second saline aqueous solutions into first and second chambers of the electrochemical cell, and applying a current across the anode and the cathode to generate first and second products, respectively is also provided. A method of facilitating operation of an electrochemical cell is also provided.

Abstract: Systems and methods are disclosed for a format agnostic document viewer with document translation that provide the ability for a user to either select a portion of the viewed document text in the format agnostic viewer and have it translated into a selected language, or for the user to have the entire document presented in the format agnostic viewer in translated form. The translated text may be shown side-by-side with the original document text in the format agnostic viewer, or can replace the original text on the visible page in the format agnostic viewer. The translated text may be formatted according to, or displayed with, some enhancements to account for differences in the original text and translated text or other differences.

Abstract: Systems and methods are disclosed for a format agnostic document viewer with document translation that provide the ability for a user to either select a portion of the viewed document text in the format agnostic viewer and have it translated into a selected language, or for the user to have the entire document presented in the format agnostic viewer in translated form. The translated text may be shown side-by-side with the original document text in the format agnostic viewer, or can replace the original text on the visible page in the format agnostic viewer. The translated text may be formatted according to, or displayed with, some enhancements to account for differences in the original text and translated text or other differences.

Abstract: A method of operating an electrochemical cell including introducing an aqueous solution into the electrochemical cell, applying a current across an anode and a cathode to produce a product, monitoring the voltage, dissolved hydrogen, or a condition of the aqueous solution, and reversing polarity of the anode and the cathode responsive to one of the measured parameters is disclosed. An electrochemical system including an electrochemical cell including an anode and a cathode, a source of an aqueous solution having an outlet fluidly connectable to the electrochemical cell, a sensor for measuring a parameter, and a controller configured to cause the anode and the cathode to reverse polarity responsive to the parameter measurement is disclosed. Methods of suppressing accumulation of hydrogen gas within the electrochemical cell are also disclosed. Methods of facilitating operation of an electrochemical cell are also disclosed.

Abstract: A method is described for training a model that refines estimated parameter values within core images is disclosed. The method includes receiving multiple training image pairs wherein each training image pair includes: (i) an unrefined core image of a rock sample to be used for estimating rock properties, and (ii) a refined core image of the same rock sample; generating a training dataset from the multiple training image pairs; receiving an initial core model; generating a conditioned core model by training, using the multiple training image pairs, the initial core model; and storing the conditioned core model in electronic storage. The conditioned core model may be applied to an initial target core image data set to generate a refined target sore image dataset. The method may be executed by a computer system.

Abstract: Systems and methods for categorizing patterns of characters in a document by utilizing machine based learning techniques include generating character classification training data, building a character classification model based on the character classification training data; obtaining an image that includes a pattern of characters, the characters including one or more contours, applying the character classification model to the image to classify the contours, and applying the labels to clusters of the contours.

Abstract: Systems and methods are disclosed for a format agnostic document viewer with document translation that provide the ability for a user to either select a portion of the viewed document text in the format agnostic viewer and have it translated into a selected language, or for the user to have the entire document presented in the format agnostic viewer in translated form. The translated text may be shown side-by-side with the original document text in the format agnostic viewer, or can replace the original text on the visible page in the format agnostic viewer. The translated text may be formatted according to, or displayed with, some enhancements to account for differences in the original text and translated text or other differences.

Abstract: A monovalent selective ion exchange membrane is disclosed. The membrane includes a polymeric microporous substrate, a cross-linked ion-transferring polymeric layer on a surface of the substrate, and a charged functionalizing layer covalently bound to the ion-transferring layer. A method of producing a monovalent selective cation exchange membrane is also disclosed. The method may include chemically adsorbing a styrene intermediate layer to a cross-linked ion-transferring polymeric layer on a surface of a polymeric microporous substrate, chlorosulfonating the styrene intermediate layer to attach a sulfonyl chloride group layer, aminating the sulfonyl group layer to attach an amine group layer, and functionalizing the amine group layer with a charged compound layer to produce the cation exchange membrane.

Abstract: Systems and methods are disclosed for a format agnostic document viewer with document translation that provide the ability for a user to either select a portion of the viewed document text in the format agnostic viewer and have it translated into a selected language, or for the user to have the entire document presented in the format agnostic viewer in translated form. The translated text may be shown side-by-side with the original document text in the format agnostic viewer, or can replace the original text on the visible page in the format agnostic viewer. The translated text may be formatted according to, or displayed with, some enhancements to account for differences in the original text and translated text or other differences.

Abstract: A method of operating an electrochemical cell including introducing an aqueous solution into the electrochemical cell, applying a current across an anode and a cathode to produce a product, monitoring the voltage, dissolved hydrogen, or a condition of the aqueous solution, and reversing polarity of the anode and the cathode responsive to one of the measured parameters is disclosed. An electrochemical system including an electrochemical cell including an anode and a cathode, a source of an aqueous solution having an outlet fluidly connectable to the electrochemical cell, a sensor for measuring a parameter, and a controller configured to cause the anode and the cathode to reverse polarity responsive to the parameter measurement is disclosed. Methods of suppressing accumulation of hydrogen gas within the electrochemical cell are also disclosed. Methods of facilitating operation of an electrochemical cell are also disclosed.

Abstract: Systems and methods for identifying patterns of symbols in standardized system diagrams are disclosed. Disclosed implementations obtain or synthetically generate a symbol recognition training data set including multiple training images, generate a symbol recognition model based on the symbol recognition training data set, obtain an image comprising a pattern of symbols, group symbols into process loops based on the logical relationships captured by process loop identification algorithm, apply a character classification model to image contours to identify the characters and group characters into tags via hierarchical clustering, and store the identified tags, symbols and identified process loops in a relational database.

Abstract: A method is described for training a model that refines estimated parameter values within core images is disclosed. The method includes receiving multiple training image pairs wherein each training image pair includes: (i) an unrefined core image of a rock sample to be used for estimating rock properties, and (ii) a refined core image of the same rock sample; generating a training dataset from the multiple training image pairs; receiving an initial core model; generating a conditioned core model by training, using the multiple training image pairs, the initial core model; and storing the conditioned core model in electronic storage. The conditioned core model may be applied to an initial target core image data set to generate a refined target sore image dataset. The method may be executed by a computer system.

Abstract: A method of operating an electrochemical cell including introducing an aqueous solution into the electrochemical cell, applying a current across an anode and a cathode to produce a product, monitoring the voltage, dissolved hydrogen, or a condition of the aqueous solution, and applying the current in a pulsed waveform responsive to one of the measured parameters is disclosed. An electrochemical system including an electrochemical cell including an anode and a cathode, a source of an aqueous solution having an outlet fluidly connectable to the electrochemical cell, a sensor for measuring a parameter, and a controller configured to cause the anode and the cathode to apply the current in a pulsed waveform responsive to the parameter measurement is disclosed. Methods of suppressing accumulation of hydrogen gas within the electrochemical cell are also disclosed. Methods of facilitating operation of an electrochemical cell are also disclosed.

Abstract: Systems and methods are disclosed for a format agnostic document viewer with document translation that provide the ability for a user to either select a portion of the viewed document text in the format agnostic viewer and have it translated into a selected language, or for the user to have the entire document presented in the format agnostic viewer in translated form. The translated text may be shown side-by-side with the original document text in the format agnostic viewer, or can replace the original text on the visible page in the format agnostic viewer. The translated text may be formatted according to, or displayed with, some enhancements to account for differences in the original text and translated text or other differences.

Abstract: Systems and methods for identifying patterns of symbols in standardized system diagrams are disclosed. Disclosed implementations obtain or synthetically generate a symbol recognition training data set including multiple training images, generate a symbol recognition model based on the symbol recognition training data set, obtain an image comprising a pattern of symbols, group symbols into process loops based on the logical relationships captured by process loop identification algorithm, apply a character classification model to image contours to identify the characters and group characters into tags via hierarchical clustering, and store the identified tags, symbols and identified process loops in a relational database.

Abstract: Systems and methods for categorizing patterns of characters in a document by utilizing machine based learning techniques include generating character classification training data, building a character classification model based on the character classification training data; obtaining an image that includes a pattern of characters, the characters including one or more contours, applying the character classification model to the image to classify the contours, and applying the labels to clusters of the contours.

Abstract: Systems and methods for treating wastewater are disclosed. Zero valent iron media may be used in a moving packed bed reactor. A media recovery system may return media to the reactor.

Abstract: Membrane modules, and contactor apparatuses that utilize these modules, comprise a membrane contactor layer and a condenser region and optionally a core. The modules comprise a membrane contactor layer comprising a membrane envelope and a plurality of hollow fiber membranes disposed therein; a feed fluid pathway defined at least in part by lumens of the hollow fibers; and a permeate fluid pathway defined at least in part by an interstitial space between outer surfaces of the hollow fibers and inner surfaces of the membrane envelope.