Patents by Inventor Paul E. Allen

Paul E. Allen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200231585
    Abstract: The present disclosure provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula (I) wherein variables A, R1, R2, R2?, R3, R4, and R5 of Formula (I) are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, and uses of the compounds and compositions for treatment of disorders and/or conditions related to A? plaque formation and deposition, resulting from the biological activity of BACE. Such BACE mediated disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairments, and other central nervous system conditions.
    Type: Application
    Filed: December 13, 2017
    Publication date: July 23, 2020
    Applicant: AMGEN INC.
    Inventors: Jennifer R. ALLEN, Albert AMEGADZIE, Matthew P. BOURBEAU, Jian J. CHEN, Michael J. FROHN, Paul E. HARRINGTON, Jonathan D. LOW, Vu V. MA, Thomas T. NGUYEN, Alexander PICKRELL, Corey REEVES
  • Publication number: 20200207747
    Abstract: The present disclosure provides a class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I: (insert Formula I structure) wherein variables W, X, Y, R2, R2?, R3, R4, R5, R6, and R7 of Formula I are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, and uses of the compounds and compositions for treatment of disorders and/or conditions related to beta amyloid (A?) plaque formation and deposition, resulting from the biological activity of BACE. Such BACE mediated disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairments, and other central nervous system conditions.
    Type: Application
    Filed: December 13, 2017
    Publication date: July 2, 2020
    Applicant: AMGEN INC.
    Inventors: Jennifer R. ALLEN, Matthew P. BOURBEAU, Ning CHEN, Michael J. FROHN, Paul E. HARRINGTON, Qingyian LIU, Corey REEVES
  • Publication number: 20200188586
    Abstract: An infusion apparatus includes a housing and a chamber configured to be connected to the housing. The apparatus further includes a weight sensor coupled to a load connector connected to the housing and an optical sensor disposed in the housing. The weight sensor is configured to generate a first signal based on a measured weight of the fluid container attached to the housing in a weight-bearing configuration. The optical sensor is configured to generate a second signal based on detecting drops of the fluid traversing the chamber. The apparatus also includes a flow control mechanism to control a flow rate of the fluid into an outlet channel. The apparatus includes one or more processing devices configured to perform operations including transmitting a control signal to the flow control mechanism to adjust the flow rate.
    Type: Application
    Filed: February 27, 2020
    Publication date: June 18, 2020
    Inventors: Nathaniel M. Sims, Eric John Flachbart, Duane Edward Allen, Benjamin James Chomyn, Paul C. Henninge, Joseph Matthew Pasquence, Andrew W. Asack, Michael H. Wollowitz, Rolf E. Zuk
  • Patent number: 10626542
    Abstract: A vertical axis laundry treating appliance having a non-encapsulated lid comprising a single panel of glass that is able to pass the UL 746C ball drop test. Non-encapsulated glass lids according to embodiments of the disclosure simplify part and assembly complexity compared to encapsulated glass lids.
    Type: Grant
    Filed: April 5, 2019
    Date of Patent: April 21, 2020
    Assignee: Whirlpool Corporation
    Inventors: Ryan L. Allen, Paul E. Brownie, Kirk M. Dunsbergen, Benjamin D. Lowell, Nicholas Schooley
  • Patent number: 10576202
    Abstract: An infusion apparatus includes a housing and a chamber configured to be connected to the housing. The apparatus further includes a weight sensor coupled to a load connector connected to the housing and an optical sensor disposed in the housing. The weight sensor is configured to generate a first signal based on a measured weight of the fluid container attached to the housing in a weight-bearing configuration. The optical sensor is configured to generate a second signal based on detecting drops of the fluid traversing the chamber. The apparatus also includes a flow control mechanism to control a flow rate of the fluid into an outlet channel. The apparatus includes one or more processing devices configured to perform operations including transmitting a control signal to the flow control mechanism to adjust the flow rate.
    Type: Grant
    Filed: November 12, 2015
    Date of Patent: March 3, 2020
    Assignee: The General Hospital Corporation
    Inventors: Nathaniel M. Sims, Eric John Flachbart, Duane Edward Allen, Benjamin James Chomyn, Paul C. Henninge, Joseph Matthew Pasquence, Andrew W. Asack, Michael H. Wollowitz, Rolf E. Zuk
  • Patent number: 10417285
    Abstract: The present disclosure provides an approach in which a domain corpus subset generator correlates documents from a document corpus to domain discernible attributes associated with domain corpus subsets. The domain corpus subset generator analyzes correlation results from the correlation and stores the documents into domain corpus subsets accordingly. In turn, a question-answer system utilizes documents included in a specific domain corpus subset to provide relevant and accurate answers to an input question.
    Type: Grant
    Filed: August 13, 2015
    Date of Patent: September 17, 2019
    Assignee: International Business Machines Corporation
    Inventors: Corville O. Allen, Paul R. Bastide, Matthew E. Broomhall, Robert E. Loredo, Fang Lu
  • Publication number: 20190234003
    Abstract: A vertical axis laundry treating appliance having a non-encapsulated lid comprising a single panel of glass that is able to pass the UL 746C ball drop test. Non-encapsulated glass lids according to embodiments of the disclosure simplify part and assembly complexity compared to encapsulated glass lids.
    Type: Application
    Filed: April 5, 2019
    Publication date: August 1, 2019
    Inventors: RYAN L. ALLEN, PAUL E. BROWNIE, KIRK M. DUNSBERGEN, BENJAMIN D. LOWELL, NICHOLAS SCHOOLEY
  • Patent number: 10287724
    Abstract: A vertical axis laundry treating appliance having a non-encapsulated lid comprising a single panel of glass that is able to pass the UL 746C ball drop test. Non-encapsulated glass lids according to embodiments of the disclosure simplify part and assembly complexity compared to encapsulated glass lids.
    Type: Grant
    Filed: August 9, 2017
    Date of Patent: May 14, 2019
    Assignee: Whirlpool Corporation
    Inventors: Ryan L. Allen, Paul E. Brownie, Kirk M. Dunsbergen, Benjamin D. Lowell, Nicholas Schooley
  • Patent number: 5932164
    Abstract: A method of molding plastic parts, particularly those with low draft angles, textured surfaces or other mold release challenges, comprising the steps of placing a cavity substantially defining the exterior of the plastic part and a core substantially defining the interior of the plastic part into position defining the plastic part therebetween and injecting heated thermoplastic between the cavity and the core to form the plastic part. The molding machine is then operated to simultaneously withdraw the core and incrementally eject the plastic part from the core by an incremental ejection distance insufficient to disengage the plastic part from the core, wherein the plastic part is supported by the cavity during the incremental ejection from the core. The molding machine is next operated to withdraw the core and the part engaged thereon from the cavity, and fully eject the part from the core.
    Type: Grant
    Filed: December 31, 1996
    Date of Patent: August 3, 1999
    Assignee: Logic Corporation
    Inventor: Paul E. Allen
  • Patent number: 4507056
    Abstract: Method and apparatus for reducing the resistance to the flow of a liquid from an upper liquid supply container to a lower vacuum receptor tank through an interconnecting port while permitting air displaced from said tank to enter said container through said port. The apparatus includes a valve element which is mounted for opening and closing movement with respect to the port and is biased into normal closed position. The valve element comprises a lower buoyant seating member or ball located in said lower tank and designed to seal said port from below, and an air conduit attached to the seating member or ball for movement therewith. The lower end of the air conduit is open adjacent the ball in the lower tank and the upper end is open to an air space above the liquid level within the upper supply container. Preferably, the valve element also includes a splash member to disrupt the liquid flow from the upper container and facilitate the air flow from the lower tank into and through the air conduit.
    Type: Grant
    Filed: October 3, 1983
    Date of Patent: March 26, 1985
    Assignee: Logic Devices, Inc.
    Inventor: Paul E. Allen
  • Patent number: 4408960
    Abstract: A pneumatic method and apparatus for causing the rapid recirculation of a liquid between a plurality of containers 10, 11 by adjusting the pressure of a gas exerted within each of said containers to superatmospheric, atmospheric and subatmospheric pressures, thereby avoiding the passing of the liquid through a mechanical flow-inducing pump. The containers 10, 11 are connected to each other by means of a liquid circulation system comprising a circulation conduit which includes a work station. A filled first container 10 is subjected to superatmospheric pressure to force the liquid into the circulation system while a second empty container 11 is subjected to subatmospheric pressure to suck the liquid from the circulation system. After each container is empty and before it is subjected to subatmospheric pressure, for refilling purposes, it is exposed to atmospheric pressure to release the elevated pressure therefrom.
    Type: Grant
    Filed: September 11, 1981
    Date of Patent: October 11, 1983
    Assignee: Logic Devices, Inc.
    Inventor: Paul E. Allen
  • Patent number: 4367785
    Abstract: Method and apparatus for providing a controlled pressure liquid circulation system comprising a circulation conduit through which a liquid can be circulated and recirculated to accomplish a desired function, such as heating and/or cooling of a work station such as a mold. The invention involves opening and closing said circulation conduit to a source of supply liquid, such as city water, at elevated pressure while maintaining the controlled pressure of the liquid within said circulation conduit at a substantially lower pressure, and is characterized by maintaining the circulation conduit open to a drain line at all times and providing or maintaining a drain pressure which is at least slightly above atmospheric and is equal to the pressure desired within the circulation conduit in the area thereof which is open to the drain.
    Type: Grant
    Filed: February 9, 1981
    Date of Patent: January 11, 1983
    Assignee: Logic Devices, Inc.
    Inventor: Paul E. Allen
  • Patent number: 4287941
    Abstract: A negative pressure cooling system for cooling passageways in plastic molds includes a closed reservoir that is maintained under a high vacuum by a vacuum fluid pump with the outlet of the cooling passageway being connected to the reservoir inlet and with the reservoir outlet being connected to the cooling passageway inlet through a pressure pump and a fluid pressure regulator.
    Type: Grant
    Filed: October 1, 1979
    Date of Patent: September 8, 1981
    Assignee: Logic Devices, Inc.
    Inventor: Paul E. Allen
  • Patent number: 4278230
    Abstract: A system for cooling plastic molds with a flowing liquid while obviating leaking of the fluid and still enabling the mold to basically determine the quantity of liquid flowing, by providing a less than atmospheric pressure within the mold and increasing where needed, the cooling effect of the flowing liquid by in effect, providing a controlled adjustable air leak.
    Type: Grant
    Filed: October 19, 1976
    Date of Patent: July 14, 1981
    Assignee: Logic Devices, Inc.
    Inventor: Paul E. Allen
  • Patent number: 4277435
    Abstract: A tumbler is formed of injected plastic material that has different directional strengths by injecting the plastic material somewhat tangentially to cause the plastic material to move peripherally in the rim defining portion of the mold cavity in order to have the weaker directional strength also extend peripherally to thereby increase the tumbler's resistance to lengthwise splitting from the rim to the bottom and in which the mold is vented into a cooling passageway.
    Type: Grant
    Filed: March 28, 1979
    Date of Patent: July 7, 1981
    Assignee: Logic Devices, Inc.
    Inventor: Paul E. Allen
  • Patent number: 4256953
    Abstract: An apparatus for motivating an operator's performance by measuring the durations in a plural step repeating work cycle of a machine of at least a step whose duration is mostly controlled by an operator and displaying for the operator's observation the duration of the immediately prior step, the average duration of said operator's steps from the beginning of a work period, the average of all operator's steps, a standard predetermined duration of the step and the maximum duration of the step that is added to the average together with displaying at least some of the same durations for at least one or more other steps performed during the cycle and/or of the complete cycle together with the number of down or non-operating occurrences and the elapsed time thereof.
    Type: Grant
    Filed: October 31, 1978
    Date of Patent: March 17, 1981
    Assignee: Logic Devices, Inc.
    Inventor: Paul E. Allen
  • Patent number: 4212623
    Abstract: A method and apparatus for forming a continuous cooling liquid passageway through two separable injection mold dies when they are closed with a supply system flowing cooling liquid at a less than atmospheric pressure at least at the junction of the dies through the passageway only when the dies are closed and air when the dies are opened and the passageway is discontinuous.
    Type: Grant
    Filed: January 31, 1979
    Date of Patent: July 15, 1980
    Assignee: Logic Devices, Inc.
    Inventor: Paul E. Allen
  • Patent number: 4208177
    Abstract: A method and system for cooling an injection molded plastic article by forming a portion of a mold cavity of fluid permeable porous material that communicates with a cooling liquid passageway and subjecting the cooling liquid to different pressures to vary the flow of fluid through the porous plug.
    Type: Grant
    Filed: May 11, 1979
    Date of Patent: June 17, 1980
    Assignee: Logic Devices, Inc.
    Inventor: Paul E. Allen
  • Patent number: 4177238
    Abstract: A method and system for cooling an injection molded plastic article by forming a portion of a mold cavity of fluid permeable porous material that communicates with a cooling liquid passageway and subjecting the cooling liquid to different pressures to vary the flow of fluid through the porous plug.
    Type: Grant
    Filed: December 14, 1977
    Date of Patent: December 4, 1979
    Assignee: Logic Devices, Inc.
    Inventor: Paul E. Allen
  • Patent number: D257775
    Type: Grant
    Filed: November 23, 1977
    Date of Patent: January 6, 1981
    Assignee: Logic Devices, Inc.
    Inventor: Paul E. Allen