Patents by Inventor Paul E. Friedrich

Paul E. Friedrich has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Optimization of energy delivery for various applications
    Patent number: 11938317
    Abstract: Energy is transmitted to a body lumen or passageway in the form of pulsed electric fields (PEFs) and in a manner which provides focal therapy. In some embodiments, PEFs are delivered through independent electrically active electrodes of an energy delivery body, typically in a monopolar fashion. Such delivery concentrates the electrical energy over a smaller surface area, resulting in stronger effects than delivery through an electrode extending circumferentially around the lumen or passageway. It also forces the electrical energy to be delivered in a staged regional approach, mitigating the effect of preferential current pathways through the surrounding tissue. Focal delivery of PEFs can provide increased tissue lethality by employing precise timing and sequencing of energy delivery to the electrodes.
    Type: Grant
    Filed: December 7, 2022
    Date of Patent: March 26, 2024
    Assignee: Galvanize Therapeutics, Inc.
    Inventors: William Sanford Krimsky, Paul Brian Friedrichs, Roman Turovskiy, Robert E. Neal, II, Jonathan Reuben Waldstreicher, Kevin James Taylor
  • HIV FUSION INHIBITOR PEPTIDES WITH IMPROVED BIOLOGICAL PROPERTIES
    Publication number: 20120040891
    Abstract: Provided is an HIV fusion inhibitor peptide having an amino acid sequence of any one of SEQ ID NO:9, SEQ ID NO:10, SEQ ID NO:11, SEQ ID NO:12, SEQ ID NO:13, SEQ ID NO:14, or SEQ ID NO:15; and provided is a pharmaceutical composition comprising a HIV fusion inhibitor peptide and one or more of a pharmaceutically acceptable carrier and macromolecular carrier, and uses and methods of treatment provided by these compositions.
    Type: Application
    Filed: August 31, 2011
    Publication date: February 16, 2012
    Inventors: John J. Dwyer, Brian L. Bray, Stephen E. Schneider, Huyi Zhang, Nicolai A. Tvermoes, Barbara E. Johnston, Paul E. Friedrich
  • HIV fusion inhibitor peptides with improved biological properties
    Patent number: 8034899
    Abstract: Provided is an HIV fusion inhibitor peptide having an amino acid sequence of any one of SEQ ID NO:9, SEQ ID NO:10, SEQ ID NO:11, SEQ ID NO:12, SEQ ID NO:13, SEQ ID NO:14, or SEQ ID NO:15; and provided is a pharmaceutical composition comprising a HIV fusion inhibitor peptide and one or more of a pharmaceutically acceptable carrier and macromolecular carrier, and uses and methods of treatment provided by these compositions.
    Type: Grant
    Filed: October 20, 2008
    Date of Patent: October 11, 2011
    Assignee: Trimeris, Inc.
    Inventors: John Dwyer, Brian L. Bray, Stephen E. Schneider, Huyi Zhang, Nicolai A. Tvermoes, Barbara E. Johnston, Paul E. Friedrich
  • NOVEL METHODS OF SYNTHESIS FOR THERAPEUTIC ANTIVIRAL PEPTIDES
    Publication number: 20100261876
    Abstract: Provided herein are methods for synthesis of peptides. In particular, provided herein are methods of synthesis for therapeutic antiviral peptides.
    Type: Application
    Filed: September 25, 2008
    Publication date: October 14, 2010
    Inventors: Brian L. Bray, Barbara E. Johnston, Stephen E. Schneider, Nicolai A. Tvermoes, Huyi Zhang, Paul E. Friedrich
  • HIV FUSION INHIBITOR PEPTIDES WITH IMPROVED BIOLOGICAL PROPERTIES
    Publication number: 20090105143
    Abstract: Provided is an HIV fusion inhibitor peptide having an amino acid sequence of any one of SEQ ID NO:9, SEQ ID NO:10, SEQ ID NO:11, SEQ ID NO:12, SEQ ID NO:13, SEQ ID NO:14, or SEQ ID NO:15; and provided is a pharmaceutical composition comprising a HIV fusion inhibitor peptide and one or more of a pharmaceutically acceptable carrier and macromolecular carrier, and uses and methods of treatment provided by these compositions.
    Type: Application
    Filed: October 20, 2008
    Publication date: April 23, 2009
    Inventors: John J. Dwyer, Brian L. Bray, Stephen E. Schneider, Huyi Zhang, Nicolai A. Tvermoes, Barbara E. Johnston, Paul E. Friedrich
  • HIV fusion inhibitor peptides with improved biological properties
    Patent number: 7456251
    Abstract: Provided is an HIV fusion inhibitor peptide having an amino acid sequence of any one of SEQ ID NO:9, SEQ ID NO:10, SEQ ID NO:11, SEQ ID NO:12, SEQ ID NO:13, SEQ ID NO:14, or SEQ ID NO:15; and provided is a pharmaceutical composition comprising a HIV fusion inhibitor peptide and one or more of a pharmaceutically acceptable carrier and macromolecular carrier, and uses and methods of treatment provided by these compositions.
    Type: Grant
    Filed: February 2, 2007
    Date of Patent: November 25, 2008
    Assignee: Trimeris, Inc.
    Inventors: John Dwyer, Brian L. Bray, Stephen E. Schneider, Huyi Zhang, Nikolai A. Tvermores, Barbara E. Johnston, Paul E. Friedrich