Patents by Inventor Paul E. Graham
Paul E. Graham has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11933665Abstract: A handheld luminometer system and assembly are shown and described. In one embodiment, an assembly includes a portable luminometer and a front end platform having a microcontroller circuit to communicate with a host device. Typically, the portable luminometer includes a sample port to accept a test sample holder, a photomultiplier assembly with at least one photomultiplier tube, and a base. The result is a luminometer assembly for use with a single-use test sample holder in communication with a host device.Type: GrantFiled: March 8, 2019Date of Patent: March 19, 2024Assignee: Charm Sciences, Inc.Inventor: Paul E Graham
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Publication number: 20210215615Abstract: Apparatus and assemblies for the detection of at least one analyte in a sample are shown and described. In one embodiment, the assembly generates a test result from an assay and includes an integrated reader and incubator, wherein the incubator incubates the assay as the reader generates the test result. The reader typically has an optical detector aligned with a light source for detecting a plurality of transmission of light on the assay. The result is systems and methods to improve the detection of the presence and/or absence of at least one analyte in a sample.Type: ApplicationFiled: March 29, 2021Publication date: July 15, 2021Applicant: Charm Sciences, Inc.Inventors: Robert J. Markovsky, Stanley E. Charm, Paul E. Graham, Richard T. Skiffington
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Patent number: 11009446Abstract: Reader observation and monitoring of the imaging of biological development is shown and described. In one embodiment, a method for monitoring biological growth includes identifying an alert from comparing a background value identified on a plate to a non-background value identified on a plate. In particular examples, a pre-filter, threshold, and histogram analysis identifies an alert count.Type: GrantFiled: October 29, 2019Date of Patent: May 18, 2021Assignee: Charm Sciences, Inc.Inventors: Richard T. Skiffington, Robert S. Salter, Robert J. Markovsky, Stanley E. Charm, Paul E. Graham, Jovo Djuragic
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Patent number: 11002683Abstract: Apparatus and assemblies for the detection of at least one analyte in a sample are shown and described. In one embodiment, the assembly generates a test result from an assay and includes an integrated reader and incubator, wherein the incubator incubates the assay as the reader generates the test result. The reader typically has an optical detector aligned with a light source for detecting a plurality of transmission of light on the assay. The result is systems and methods to improve the detection of the presence and/or absence of at least one analyte in a sample.Type: GrantFiled: February 19, 2019Date of Patent: May 11, 2021Assignee: Charm Sciences, Inc.Inventors: Robert J. Markovsky, Stanley E. Charm, Paul E. Graham, Richard T. Skiffington
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Publication number: 20210016271Abstract: In-line testing and product delivery assemblies, methods, operations, and systems are shown and described. In one embodiment, an in-line testing and product delivery system includes a supply of product having at least one outlet with a valve closure and a downstream delivery line, a recirculation closed loop in fluid communication with the outlet and supply, and a reader to generate a rapid test result from a single use assay for detection of a presence or an absence of an analyte in the supply. The result provides monitoring of a detection of the analyte to block release of product supply into the delivery line.Type: ApplicationFiled: March 4, 2019Publication date: January 21, 2021Applicant: Charm Sciences, Inc.Inventors: Robert J. MARKOVSKY, Robert SALTER, David W. DOUGLAS, Paul E. GRAHAM, Alan C. TRAN, Ryan N. SULLIVAN
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Publication number: 20200217799Abstract: System, apparatus, and assemblies for the detection of at least one analyte in a sample are shown and described. The system may be an onboard vehicle system to generate an antibiotic test result from an antibiotic analyte assay.Type: ApplicationFiled: March 20, 2020Publication date: July 9, 2020Applicant: Charm Sciences, Inc.Inventors: Robert J. Markovsky, Stanley E. Charm, Paul E. Graham, Richard T. Skiffington
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Publication number: 20200080044Abstract: Reader and plate methods, operations, and systems for imaging/counting biological development on plates are shown and described. One embodiment includes calibrating a plate reader. Calibration may be triggered by detecting a quality control event or the like. The calibration process may include receiving a low and/or high calibrator, counting objects on the calibrator(s), and comparing objects on the calibrator(s) to a predetermined limit. The result is an improved plate reader for observing biological growth, when present, on a growth plate.Type: ApplicationFiled: April 28, 2017Publication date: March 12, 2020Applicant: Charm Sciences, Inc.Inventors: Robert J. Markovsky, Paul E. Graham, Richard T. Skiffington, Scott Sutherland
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Patent number: 10563164Abstract: Reader and plate methods, operations, and systems for observing a biological sample are shown and described. In one embodiment, a reader device includes selecting a plate type between at least two plate type selections on a user interface. One embodiment includes aligning a peel plate within a tray holder nest to define a semi-fixed processing position. One embodiment includes transporting a peel plate from a loading position into a focal alignment with an imaging device for monitoring biological growth, when present.Type: GrantFiled: October 11, 2016Date of Patent: February 18, 2020Assignee: Charm Sciences, Inc.Inventors: Richard T Skiffington, Robert S Salter, Robert J Markovsky, Stanley E Charm, Paul E Graham, Byron A. Roberts
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Publication number: 20190178802Abstract: Apparatus and assemblies for the detection of at least one analyte in a sample are shown and described. In one embodiment, the assembly generates a test result from an assay and includes an integrated reader and incubator, wherein the incubator incubates the assay as the reader generates the test result. The reader typically has an optical detector aligned with a light source for detecting a plurality of transmission of light on the assay. The result is systems and methods to improve the detection of the presence and/or absence of at least one analyte in a sample.Type: ApplicationFiled: February 19, 2019Publication date: June 13, 2019Applicant: Charm Sciences, Inc.Inventors: Robert J. Markovsky, Stanley E. Charm, Paul E. Graham, Richard T. Skiffington
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Patent number: 10254233Abstract: Apparatus and assemblies for the detection of at least one analyte in a sample are shown and described. In one embodiment, the assembly generates a test result from an assay and includes an integrated reader and incubator, wherein the incubator incubates the assay as the reader generates the test result. The reader typically has an optical detector aligned with a light source for detecting a plurality of transmission of light on the assay. The result is systems and methods to improve the detection of the presence and/or absence of at least one analyte in a sample.Type: GrantFiled: April 20, 2018Date of Patent: April 9, 2019Assignee: Charm Sciences, Inc.Inventors: Robert J. Markovsky, Stanley E. Charm, Paul E. Graham, Richard T. Skiffington
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Publication number: 20180238809Abstract: Apparatus and assemblies for the detection of at least one analyte in a sample are shown and described. In one embodiment, the assembly generates a test result from an assay and includes an integrated reader and incubator, wherein the incubator incubates the assay as the reader generates the test result. The reader typically has an optical detector aligned with a light source for detecting a plurality of transmission of light on the assay. The result is systems and methods to improve the detection of the presence and/or absence of at least one analyte in a sample.Type: ApplicationFiled: April 20, 2018Publication date: August 23, 2018Applicant: Charm Sciences, Inc.Inventors: Robert J. Markovsky, Stanley E. Charm, Paul E. Graham, Richard T. Skiffington
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Patent number: 9976962Abstract: Apparatus and assemblies for the detection of at least one analyte in a sample are shown and described. In one embodiment, the assembly generates a test result from an assay and includes an integrated reader and incubator, wherein the incubator incubates the assay as the reader generates the test result. The reader typically has an optical detector aligned with a light source for detecting a plurality of transmission of light on the assay. The result is systems and methods to improve the detection of the presence and/or absence of at least one analyte in a sample.Type: GrantFiled: December 8, 2017Date of Patent: May 22, 2018Assignee: Charm Sciences, Inc.Inventors: Robert J. Markovsky, Stanley E. Charm, Paul E. Graham, Richard T. Skiffington
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Publication number: 20180100805Abstract: Apparatus and assemblies for the detection of at least one analyte in a sample are shown and described. In one embodiment, the assembly generates a test result from an assay and includes an integrated reader and incubator, wherein the incubator incubates the assay as the reader generates the test result. The reader typically has an optical detector aligned with a light source for detecting a plurality of transmission of light on the assay. The result is systems and methods to improve the detection of the presence and/or absence of at least one analyte in a sample.Type: ApplicationFiled: December 8, 2017Publication date: April 12, 2018Applicant: Charm Sciences, Inc.Inventors: Robert J. Markovsky, Stanley E. Charm, Paul E. Graham, Richard T. Skiffington
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Publication number: 20180059116Abstract: Analyte detection systems and devices are provided. In one embodiment, a sensor initially reviews an assay, for instance a test strip, to designate a particular testing sequence. The sensor may calibrate the unit and then identify the particular testing sequence by identifying a color indicator on the test strip. The result is systems and methods to improve the detection of the presence and/or absence of at least one analyte in a sample.Type: ApplicationFiled: July 10, 2017Publication date: March 1, 2018Applicant: Charm Sciences, Inc.Inventors: PAUL E GRAHAM, Robert J. Markovsky
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Patent number: 9488657Abstract: Analyte detection systems and devices are provided. In one embodiment, a sensor initially reviews an assay, for instance a test strip, to designate a particular testing sequence. The sensor may calibrate the unit and then identify the particular testing sequence by identifying a color indicator on the test strip. The result is systems and methods to improve the detection of the presence and/or absence of at least one analyte in a sample.Type: GrantFiled: March 13, 2014Date of Patent: November 8, 2016Assignee: Charm Sciences, Inc.Inventors: Paul E. Graham, Robert J. Markovsky
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Publication number: 20140334980Abstract: Analyte detection systems and devices are provided. In one embodiment, a sensor initially reviews an assay, for instance a test strip, to designate a particular testing sequence. The sensor may calibrate the unit and then identify the particular testing sequence by identifying a color indicator on the test strip. The result is systems and methods to improve the detection of the presence and/or absence of at least one analyte in a sample.Type: ApplicationFiled: March 13, 2014Publication date: November 13, 2014Applicant: Charm Sciences, Inc.Inventors: Paul E. Graham, Robert J. Markovsky
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Publication number: 20140271362Abstract: Test strips for the detection of at least one analyte in a sample are shown and described. In one embodiment, the test strip includes a test zone, a control zone and a surface reflectance profile to monitor the test strip continuously until the presence or absence of an analyte is detected. In other embodiments, a lateral flow assay includes a surface reflectance profile to monitor the test strip prior to the detection. The surface reflectance profile may include at least one flow reference area and/or at least one test result reference area. The result is systems and methods to improve the detection of the presence and/or absence of at least one analyte in a sample.Type: ApplicationFiled: March 12, 2013Publication date: September 18, 2014Inventors: Robert J. Markovsky, Stanley E. Charm, Paul E. Graham, Richard T. Skiffington
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Publication number: 20140057362Abstract: Lateral flow assay analysis is shown and described. In one embodiment, the lateral flow assay comprises a surface having a reflectance profile that is adapted to enable monitoring of the assay continuously until the detection of an analyte. In other embodiments, a lateral flow assay system includes an incubator and a reader, wherein the incubator incubates the assay concurrently as the reader generates a test result. Further, an assay measurement apparatus may include an optical detector to perform continuous image detection of the assay to generate a diagnostic test result.Type: ApplicationFiled: August 25, 2011Publication date: February 27, 2014Inventors: Robert J. Markovsky, Stanley E. Charm, Paul E. Graham, Richard T. Skiffington