Patents by Inventor Paul E. Makidon
Paul E. Makidon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20260191951Abstract: The present invention provides methods and compositions for the stimulation of immune responses and for treating or preventing allergic disease and responses and inflammatory disease and responses. In particular, the present invention provides nanoemulsion compositions and methods of using the same for the induction of immune responses that prevent or treat allergic disease by reducing allergic response. Compositions and methods of the invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine (e.g., vaccination)) and research applications.Type: ApplicationFiled: September 2, 2025Publication date: July 9, 2026Inventors: James R. BAKER, JR., Anna U. BIELINSKA, Douglas SMITH, Paul E. MAKIDON, Jessica J. O'KONEK
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Patent number: 12403192Abstract: The present invention provides methods and compositions for the stimulation of immune responses and for treating or preventing allergic disease and responses and inflammatory disease and responses. In particular, the present invention provides nanoemulsion compositions and methods of using the same for the induction of immune responses that prevent or treat allergic disease by reducing allergic response. Compositions and methods of the invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine (e.g., vaccination)) and research applications.Type: GrantFiled: October 3, 2023Date of Patent: September 2, 2025Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: James R. Baker, Jr., Anna U. Bielinska, Douglas Smith, Paul E. Makidon, Jessica J. O'Konek
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Publication number: 20240058439Abstract: The present invention provides methods and compositions for the stimulation of immune responses and for treating or preventing allergic disease and responses and inflammatory disease and responses. In particular, the present invention provides nanoemulsion compositions and methods of using the same for the induction of immune responses that prevent or treat allergic disease by reducing allergic response. Compositions and methods of the invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine (e.g., vaccination)) and research applications.Type: ApplicationFiled: October 3, 2023Publication date: February 22, 2024Inventors: James R. BAKER, Jr., Anna U. BIELINSKA, Douglas SMITH, Paul E. MAKIDON, Jessica J. O'KONEK
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Patent number: 11806318Abstract: The present invention provides methods and compositions for the stimulation of immune responses and for treating or preventing allergic disease and responses and inflammatory disease and responses. In particular, the present invention provides nanoemulsion compositions and methods of using the same for the induction of immune responses that prevent or treat allergic disease by reducing allergic response. Compositions and methods of the invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine (e.g., vaccination)) and research applications.Type: GrantFiled: July 6, 2021Date of Patent: November 7, 2023Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: James R. Baker, Jr., Anna U. Bielinska, Douglas Smith, Paul E. Makidon, Jessica J. O'Konek
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Publication number: 20210401975Abstract: The present invention provides methods and compositions for the stimulation of immune responses and for treating or preventing allergic disease and responses and inflammatory disease and responses. In particular, the present invention provides nanoemulsion compositions and methods of using the same for the induction of immune responses that prevent or treat allergic disease by reducing allergic response. Compositions and methods of the invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine (e.g., vaccination)) and research applications.Type: ApplicationFiled: July 6, 2021Publication date: December 30, 2021Inventors: James R. BAKER, JR., Anna U. BIELINSKA, Douglas SMITH, Paul E. MAKIDON, Jessica J. O'KONEK
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Patent number: 11083788Abstract: The present invention provides methods and compositions for the stimulation of immune responses and for treating or preventing allergic disease and responses and inflammatory disease and responses. In particular, the present invention provides nanoemulsion compositions and methods of using the same for the induction of immune responses that prevent or treat allergic disease by reducing allergic response. Compositions and methods of the invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine (e.g., vaccination)) and research applications.Type: GrantFiled: October 9, 2015Date of Patent: August 10, 2021Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: James R. Baker, Jr., Anna U. Bielinska, Douglas Smith, Paul E. Makidon, Jessica J. O'Konek
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Patent number: 9801842Abstract: The present invention relates to methods and compositions for treating pulmonary infection. In particular, the present invention provides nanoemulsion compositions and methods of using the same to treat bacteria associated with biofilms (e.g., found in pulmonary infections). Compositions and methods of the present invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine), industrial, and research applications.Type: GrantFiled: June 9, 2014Date of Patent: October 31, 2017Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: James R. Baker, Jr., Sivaprakash Rathinavelu, Paul E. Makidon, John J. LiPuma, Shraddha Nigavekar
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Publication number: 20170246294Abstract: The present invention provides methods and compositions for the stimulation of immune responses and for treating or preventing allergic disease and responses and inflammatory disease and responses. In particular, the present invention provides nanoemulsion compositions and methods of using the same for the induction of immune responses that prevent or treat allergic disease by reducing allergic response. Compositions and methods of the invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine (e.g., vaccination)) and research applications.Type: ApplicationFiled: October 9, 2015Publication date: August 31, 2017Inventors: James R. BAKER, JR., Anna U. BIELINSKA, Douglas SMITH, Paul E. MAKIDON, Jessica J. O'KONEK
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Patent number: 9415006Abstract: The present invention provides methods and compositions for the stimulation of immune responses. Specifically, the present invention provides immunogenic compositions and methods of using the same to induce immune responses (e.g., immunity (e.g., protective immunity)) against Hepatitis B virus (HBV)). Compositions and methods of the present invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine (e.g., vaccination)) and research applications.Type: GrantFiled: May 26, 2009Date of Patent: August 16, 2016Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: James R. Baker, Jr., Anna U. Bielinska, Nicholas Mank, Paul E. Makidon, Zhengyi Cao, Alison J Scott, Shraddha S. Nigavekar
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Publication number: 20160158179Abstract: The present invention relates to therapeutic nanoemulsion compositions and to methods of utilizing the same. In particular, nanoemulsion compositions are described herein that find use in the treatment and/or prevention of infection (e.g., respiratory infection (e.g., associated with cystic fibrosis)), in burn wound management, and in immunogenic compositions (e.g., comprising a Burkholderia antigen) that generate an effective immune response (e.g., against a bacterial species of the genus Burkholderia) in a subject administered the immunogenic composition. Compositions and methods of the present invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine), industrial, and research applications.Type: ApplicationFiled: February 11, 2016Publication date: June 9, 2016Inventors: James R. Baker, Jr., Mark R. Hemmila, Stewart C. Wang, Tarek Hamouda, John J. LiPuma, Jessica Ann Knowlton, Paul E. Makidon, Luz Blanco, Jeffery V. Groom, II, Anna U. Bielinska
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Patent number: 9259407Abstract: The present invention relates to therapeutic nanoemulsion compositions and to methods of utilizing the same. In particular, nanoemulsion compositions are described herein that find use in the treatment and/or prevention of infection (e.g., respiratory infection (e.g., associated with cystic fibrosis)), in burn wound management, and in immunogenic compositions (e.g., comprising a Burkholderia antigen) that generate an effective immune response (e.g., against a bacterial species of the genus Burkholderia) in a subject administered the immunogenic composition. Compositions and methods of the present invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine), industrial, and research applications.Type: GrantFiled: February 23, 2015Date of Patent: February 16, 2016Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: James R. Baker, Jr., Mark R. Hemmila, Stewart C. Wang, Tarek Hamouda, John J. LiPuma, Jessica Ann Knowlton, Paul E. Makidon, Luz Blanco, Jeffery V. Groom, II, Anna U. Bielinska
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Publication number: 20150216826Abstract: The present invention relates to therapeutic nanoemulsion compositions and to methods of utilizing the same. In particular, nanoemulsion compositions are described herein that find use in the treatment and/or prevention of infection (e.g., respiratory infection (e.g., associated with cystic fibrosis)), in burn wound management, and in immunogenic compositions (e.g., comprising a Burkholderia antigen) that generate an effective immune response (e.g., against a bacterial species of the genus Burkholderia) in a subject administered the immunogenic composition. Compositions and methods of the present invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine), industrial, and research applications.Type: ApplicationFiled: February 23, 2015Publication date: August 6, 2015Inventors: James R. Baker, JR., Mark R. Hemmila, Stewart C. Wang, Tarek Hamouda, John J. LiPuma, Jessica Ann Knowlton, Paul E. Makidon, Luz Blanco, Jeffery V. Groom, II, Anna U. Bielinska
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Patent number: 8962026Abstract: The present invention relates to therapeutic nanoemulsion compositions and to methods of utilizing the same. In particular, nanoemulsion compositions are described herein that find use in the treatment and/or prevention of infection (e.g., respiratory infection (e.g., associated with cystic fibrosis)), in burn wound management, and in immunogenic compositions (e.g., comprising a Burkholderia antigen) that generate an effective immune response (e.g., against a bacterial species of the genus Burkholderia) in a subject administered the immunogenic composition. Compositions and methods of the present invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine), industrial, and research applications.Type: GrantFiled: September 25, 2009Date of Patent: February 24, 2015Assignee: The Regents of the University of MichiganInventors: James R. Baker, Jr., Mark R. Hemmila, Stewart C. Wang, Tarek Hamouda, John J. LiPuma, Jessica A. Knowlton, Paul E. Makidon, Luz P. Blanco, Jeffery V. Groom, II, Anna U. Bielinska
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Publication number: 20150050318Abstract: The present invention provides methods and compositions for the stimulation of immune responses. Specifically, the present invention provides methods of inducing an immune response against one or a plurality of pathogens (e.g., vaccinia virus, H5N1 influenza virus, Bacillus anthracis, C. botulinum, Y. pestis, Hepatits B, and/or HIV, etc.) in a subject (e.g., a human subject) and compositions useful in such methods (e.g., immunogenic composition comprising nanoemulsion and one or a plurality of pathogens (e.g., inactivated by the nanoemulsion) and/or pathogen products and/or pathogen components). Compositions and methods of the present invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine (e.g.Type: ApplicationFiled: November 4, 2014Publication date: February 19, 2015Inventors: James R. Baker, JR., Anna U. Bielinska, Nicholas J. Mank, Paul E. Makidon, Jessica A. Knowlton, Luz P. Blanco
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Patent number: 8877208Abstract: The present invention provides methods and compositions for the stimulation of immune responses. Specifically, the present invention provides methods of inducing an immune response against one or a plurality of pathogens (e.g., vaccinia virus, H5N1 influenza virus, Bacillus anthracis, C. botulinum, Y. pestis, Hepatitis B, and/or HIV, etc.) in a subject (e.g., a human subject) and compositions useful in such methods (e.g., immunogenic composition comprising nanoemulsion and one or a plurality of pathogens (e.g., inactivated by the nanoemulsion) and/or pathogen products and/or pathogen components). Compositions and methods of the present invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine (e.g., vaccination)) and research applications.Type: GrantFiled: May 26, 2009Date of Patent: November 4, 2014Assignee: The Regents of the University of MichiganInventors: James R. Baker, Jr., Paul E. Makidon, Nicholas J. Mank, Anna U. Bielinska, Luz P. Blanco, Jessica Knowlton
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Publication number: 20140287047Abstract: The present invention relates to methods and compositions for treating pulmonary infection. In particular, the present invention provides nanoemulsion compositions and methods of using the same to treat bacteria associated with biofilms (e.g., found in pulmonary infections). Compositions and methods of the present invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine), industrial, and research applications.Type: ApplicationFiled: June 9, 2014Publication date: September 25, 2014Inventors: James R. Baker, JR., Sivaprakash Rathinavelu, Paul E. Makidon, John J. LiPuma, Shraddha Nigavekar
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Publication number: 20140193461Abstract: The present invention provides methods and compositions for the stimulation of immune responses. In particular, the present invention provides immunogenic nanoemulsion compositions and methods of using the same for the induction of immune responses (e.g., innate and/or adaptive immune responses (e.g., for generation of host immunity against a bacterial species of the genus Streptococcus (e.g., Streptococcus pneumoniae))). Compositions and methods of the present invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine (e.g., vaccination)) and research applications.Type: ApplicationFiled: March 10, 2014Publication date: July 10, 2014Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: James R. Baker, JR., Paul E. Makidon, Whitney A. Dunlap, Jessica A. Knowlton, Benjamin Swanson
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Patent number: 8747872Abstract: The present invention relates to methods and compositions for treating pulmonary infection. In particular, the present invention provides nanoemulsion compositions and methods of using the same to treat bacteria associated with biofilms (e.g., found in pulmonary infections). Compositions and methods of the present invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine), industrial, and research applications.Type: GrantFiled: May 2, 2008Date of Patent: June 10, 2014Assignee: The Regents of the University of MichiganInventors: James R. Baker, Sivaprakash Rathinavelu, Paul E. Makidon, John J. LiPuma, Shraddha Nigavekar
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Patent number: 8668911Abstract: The present invention provides methods and compositions for the stimulation of immune responses. In particular, the present invention provides immunogenic nanoemulsion compositions and methods of using the same for the induction of immune responses (e.g., innate and/or adaptive immune responses (e.g., for generation of host immunity against a bacterial species of the genus Streptococcus (e.g., Streptococcus pneumoniae))). Compositions and methods of the present invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine (e.g., vaccination)) and research applications.Type: GrantFiled: May 14, 2010Date of Patent: March 11, 2014Assignee: The Regents Of The University Of MichiganInventors: James R. Baker, Jr., Paul E. Makidon, Whitney A. Dunlap, Jessica A. Knowlton, Benjamin Swanson
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Publication number: 20120258137Abstract: The invention provides immunogenic compositions and methods of using the same to induce immune responses (e.g., humoral, mucosal, and/or cell-mediated immune responses) against Hepatitis B virus (HBV)). Compositions and methods of the invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine (e.g., vaccination (e.g., of patient populations at risk for acute and/or chronic HBV infection))) and research applications.Type: ApplicationFiled: June 4, 2012Publication date: October 11, 2012Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: James R. Baker, JR., Douglas Smith, Paul E. Makidon