Patents by Inventor Paul E. Monahan

Paul E. Monahan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for enhanced parvovirus transduction
    Patent number: 9169492
    Abstract: The present invention provides methods and compositions for enhanced transduction of an adeno-associated virus (AAV) vector comprising a heterologous nucleic acid of interest wherein the AAV vector genome is oversized relative to a wild type AAV genome by employing a proteasome inhibitor.
    Type: Grant
    Filed: February 4, 2011
    Date of Patent: October 27, 2015
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Paul E. Monahan, Richard Jude Samulski
  • Compositions and Methods for Enhanced Parvovirus Transduction
    Publication number: 20130012574
    Abstract: The present invention provides methods and compositions for enhanced transduction of an adeno-associated virus (AAV) vector comprising a heterologous nucleic acid of interest wherein the AAV vector genome is oversized relative to a wild type AAV genome by employing a proteasome inhibitor.
    Type: Application
    Filed: February 4, 2011
    Publication date: January 10, 2013
    Inventors: Paul E. Monahan, Richard Jude Samulski
  • Methods and compounds for controlled release of recombinant parvovirus vectors
    Patent number: 7923436
    Abstract: The invention uses recombinant parvoviruses, and particularly recombinant adeno-associated virus (rAAV) to deliver genes and DNA sequences for gene therapy following manipulation of the therapeutic virus for packaging and transport. The invention delivers therapeutic viral vectors via rAAV affixed to support matrixes (i.e., sutures, surgically implantable materials, grafts, and the like).
    Type: Grant
    Filed: April 5, 2007
    Date of Patent: April 12, 2011
    Assignee: University of North Carolina - Chapel Hill
    Inventors: Paul E. Monahan, Richard Jude Samulski, Joseph E. Rabinowitz
  • METHODS AND COMPOSITIONS FOR INTRA-ARTICULAR COAGULATION PROTEINS
    Publication number: 20100137211
    Abstract: The present invention provides methods and compositions for treating blood clotting factor disorders and/or reducing bleeding-associated joint damage by treatments delivered to the joint in a subject.
    Type: Application
    Filed: April 11, 2008
    Publication date: June 3, 2010
    Inventors: Paul E. Monahan, Richard Jude Samulski, Darrel W. Stafford
  • Methods and compounds for controlled release of recombinant parvovirus vectors
    Patent number: 7201898
    Abstract: The invention uses recombinant parvoviruses, and particularly recombinant adeno-associated virus (rAAV) to deliver genes and DNA sequences for gene therapy following manipulation of the therapeutic virus for packaging and transport. The invention delivers therapeutic viral vectors via rAAV affixed to support matrixes (i.e., sutures, surgically implantable materials, grafts, and the like).
    Type: Grant
    Filed: June 1, 2001
    Date of Patent: April 10, 2007
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Paul E. Monahan, Richard Jude Samulski, Joseph E. Rabinowitz
  • Methods and compounds for controlled release of recombinant parvovirus vectors
    Publication number: 20040013645
    Abstract: The invention uses recombinant parvoviruses, and particularly recombinant adeno-associated virus (rAAV) to deliver genes and DNA sequences for gene therapy following manipulation of the therapeutic virus for packaging and transport. The invention delivers therapeutic viral vectors via rAAV affixed to support matrixes (i.e., sutures, surgically implantable materials, grafts, and the like).
    Type: Application
    Filed: December 19, 2002
    Publication date: January 22, 2004
    Inventors: Paul E. Monahan, Richard Jude Samulski, Joseph E. Rabinowitz