Patents by Inventor Paul E. Whitley

Paul E. Whitley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and intermediates for the preparation bile acid derivatives
    Patent number: 11072631
    Abstract: The present invention relates to methods and novel intermediates useful in the preparation of a compound of formula (A) or a pharmaceutically acceptable salt thereof, comprising converting the aldehyde of a compound of formula (B) with a reducing agent to prepare a compound of formula (C) and converting the compound of formula (C) with a sulfating reagent to prepare a compound of formula (A). An objective of the present invention is to provide methods of preparing bile acid derivatives and novel intermediates. A use of the methods and intermediates described relates to the synthesis of bile acid derivatives which activate both FXR and TGR5.
    Type: Grant
    Filed: September 23, 2016
    Date of Patent: July 27, 2021
    Assignee: Intercept Pharmaceuticals, Inc.
    Inventors: Kevin Schaab, Paul E. Whitley, Flavio Chavez Lopez, Kayla R. Iorga
  • METHODS AND INTERMEDIATES FOR THE PREPARATION BILE ACID DERIVATIVES
    Publication number: 20200239515
    Abstract: The present invention relates to methods and novel intermediates useful in the preparation of a compound or a pharmaceutically acceptable salt thereof. An objective of the present invention is to provide methods of preparing bile acid derivatives and novel intermediates. A use of the methods and intermediates described relates to the synthesis of bile acid derivatives which activate both FXR and TGR5.
    Type: Application
    Filed: September 23, 2016
    Publication date: July 30, 2020
    Inventors: Kevin Schaab, Paul E. Whitley, Flavio Chavez, Kayia R. lorga